A0JN71

PR
Gene name
SASH3
Protein name
SAM and SH3 domain-containing protein 3
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:534137
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-198 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0JN71

Entry ID Method Resolution Chain Position Source
AF-A0JN71-F1 Predicted AlphaFoldDB

159 variants for A0JN71

Variant ID(s) Position Change Description Diseaes Association Provenance
rs444189134 3 R>G No EVA
rs462818832 3 R>L No EVA
rs444189134 3 R>S No EVA
rs438807113 5 K>Q No EVA
rs460521483 6 P>R No EVA
rs478990929 16 Q>P No EVA
rs437190957 33 K>I No EVA
rs452390477 35 K>N No EVA
rs471120957 40 V>G No EVA
rs476167111 52 I>M No EVA
rs439929010 58 S>R No EVA
rs458442866 61 T>P No EVA
rs477036715 74 K>* No EVA
rs440800104 82 R>Q No EVA
rs459441774 88 T>R No EVA
rs481083665 91 K>T No EVA
rs470002862 93 V>E No EVA
rs448281461 93 V>L No EVA
rs482046185 95 A>D No EVA
rs445940965 97 S>L No EVA
rs464283676 98 E>Q No EVA
rs478313943 112 T>A No EVA
rs434163805 115 D>G No EVA
rs456071343 119 D>N No EVA
rs468053381 121 P>R No EVA
rs456893171 126 M>K No EVA
rs456893171 126 M>R No EVA
rs475526128 129 A>D No EVA
rs439322758 131 S>A No EVA
rs451280634 131 S>Y No EVA
rs440119585 133 Q>R No EVA
rs461878169 134 E>A No EVA
rs480519178 134 E>D No EVA
rs444405320 136 R>W No EVA
rs462992353 137 E>* No EVA
rs445404039 139 P>A No EVA
rs449453995 147 T>K No EVA
rs460502370 151 L>V No EVA
rs442943169 158 S>A No EVA
rs483273662 160 N>D No EVA
rs450152860 165 S>P No EVA
rs459268075 166 T>P No EVA
rs447876493 170 Y>S No EVA
rs466431919 171 T>P No EVA
rs433548575 171 T>R No EVA
rs467400013 172 G>S No EVA
rs437794759 172 G>V No EVA
rs456240574 173 P>R No EVA
rs432282406 179 R>G No EVA
rs454003850 181 H>Y No EVA
rs462755317 182 T>S No EVA
rs472635194 184 F>C No EVA
rs442787655 184 F>L No EVA
rs461465706 185 T>P No EVA
rs476694064 186 P>T No EVA
rs443830098 187 S>I No EVA
rs459014649 188 P>S No EVA
rs441512969 189 Y>* No EVA
rs459867492 190 D>E No EVA
rs876006301 190 D>G No EVA
rs465056210 198 K>E No EVA
rs447441973 207 K>Q No EVA
rs466089680 207 K>T No EVA
rs454804782 208 P>A No EVA
rs470213054 209 P>H No EVA
rs452493337 212 T>A No EVA
rs452493337 212 T>P No EVA
rs470866784 213 W>L No EVA
rs441382495 217 L>V No EVA
rs464051476 221 M>I No EVA
rs442325346 221 M>R No EVA
rs475213189 221 M>V No EVA
rs443195610 223 S>C No EVA
rs476250514 223 S>T No EVA
rs443195610 223 S>Y No EVA
rs447365174 226 F>L No EVA
rs477073680 226 F>V No EVA
rs459516586 227 I>L No EVA
rs481254525 227 I>S No EVA
rs459516586 227 I>V No EVA
rs448334712 228 Y>C No EVA
rs464514471 230 D>E No EVA
rs445971141 230 D>G No EVA
rs437168304 230 D>N No EVA
rs453267816 231 V>G No EVA
rs434876980 231 V>L No EVA
rs476105457 234 E>D No EVA
rs443257121 235 E>A No EVA
rs470568952 239 P>A No EVA
rs459446355 240 A>G No EVA
rs481280803 241 R>C No EVA
rs448228110 241 R>P No EVA
rs463635045 243 S>I No EVA
rs445884628 245 R>P No EVA
rs464426460 248 K>N No EVA
rs434737488 249 G>A No EVA
rs434737488 249 G>V No EVA
rs446948534 250 K>T No EVA
rs435789557 251 R>S No EVA
rs468648853 251 R>T No EVA
rs457500319 253 K>R No EVA
rs476124206 254 P>S No EVA
rs470630542 260 L>R No EVA
rs440796255 261 L>R No EVA
rs474689730 265 G>C No EVA
rs474689730 265 G>S No EVA
rs451024360 268 E>D No EVA
rs480668800 268 E>Q No EVA
rs469428753 269 H>P No EVA
rs478412539 271 S>P No EVA
rs445424486 272 T>P No EVA
rs467289836 275 L>P No EVA
rs434303722 279 Q>E No EVA
rs449484204 280 T>P No EVA
rs468235071 284 F>L No EVA
rs435174168 287 L>P No EVA
rs432960956 289 E>D No EVA
rs475265429 289 E>Q No EVA
rs451366457 290 T>P No EVA
rs440332745 291 H>N No EVA
rs462019971 291 H>P No EVA
rs463069191 299 D>A No EVA
rs444352314 299 D>Y No EVA
rs478273655 308 T>P No EVA
rs433727908 325 E>A No EVA
rs433727908 325 E>G No EVA
rs474075871 329 S>I No EVA
rs444468406 329 S>R No EVA
rs462981235 332 E>D No EVA
rs471777260 333 P>T No EVA
rs438963439 334 A>G No EVA
rs479259793 335 V>G No EVA
rs461672007 336 S>G No EVA
rs483320555 336 S>I No EVA
rs450271926 336 S>R No EVA
rs468837521 337 T>A No EVA
rs1116752377 338 V>A No EVA
rs466587558 340 D>Y No EVA
rs433786350 343 V>G No EVA
rs455420694 345 I>F No EVA
rs437933002 348 D>A No EVA
rs456420135 348 D>E No EVA
rs437933002 348 D>G No EVA
rs471837068 349 S>Y No EVA
rs454210407 350 G>A No EVA
rs443031675 351 C>G No EVA
rs461535873 352 F>V No EVA
rs483008369 354 G>D No EVA
rs443935753 355 S>F No EVA
rs459037436 356 E>D No EVA
rs444767472 362 A>G No EVA
rs478777674 363 E>G No EVA
rs467583972 370 Q>H No EVA
rs437793992 371 L>M No EVA
rs456432274 371 L>P No EVA
rs465221946 372 H>D No EVA
rs454012894 376 L>Q No EVA
rs472610196 377 S>T No EVA
rs442928376 379 A>P No EVA

No associated diseases with A0JN71

3 regional properties for A0JN71

Type Name Position InterPro Accession
domain SH3 domain 173 - 234 IPR001452
domain Sterile alpha motif domain 249 - 316 IPR001660
domain SAM and SH3 domain-containing protein 3, SH3 domain 176 - 231 IPR035721

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

17 GO annotations of biological process

Name Definition
B cell homeostasis The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
B cell proliferation The expansion of a B cell population by cell division. Follows B cell activation.
CD4-positive, alpha-beta T cell differentiation The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell.
homeostasis of number of cells within a tissue Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue.
positive regulation of adaptive immune response Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.
positive regulation of B cell proliferation Any process that activates or increases the rate or extent of B cell proliferation.
positive regulation of CD4-positive, alpha-beta T cell differentiation Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell differentiation.
positive regulation of immunoglobulin production Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.
positive regulation of interferon-gamma production Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
positive regulation of interleukin-10 production Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.
positive regulation of interleukin-2 production Any process that activates or increases the frequency, rate, or extent of interleukin-2 production.
positive regulation of interleukin-4 production Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.
positive regulation of organ growth Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism.
positive regulation of T cell cytokine production Any process that activates or increases the frequency, rate, or extent of T cell cytokine production.
positive regulation of T cell proliferation Any process that activates or increases the rate or extent of T cell proliferation.
positive regulation of tumor necrosis factor production Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production.
T cell proliferation The expansion of a T cell population by cell division. Follows T cell activation.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O75995 SASH3 SAM and SH3 domain-containing protein 3 Homo sapiens (Human) PR
Q8K352 Sash3 SAM and SH3 domain-containing protein 3 Mus musculus (Mouse) PR
10 20 30 40 50 60
MLRRKPSNAS EKEPTQKKKL SLQRSSSFKD FAKSKPSSPV VSEKEFNLDD NIPEDESSVP
70 80 90 100 110 120
TPEDAEKSGK KLGKKWRAVI SRTMNRKTGK KMVKALSEEM GDTLEEGSAS PTSPDCSLDS
130 140 150 160 170 180
PGPEKMALAF SEQEERELPA LSRQASTGSE LCSPSPGSGN LGEESTAPQY TGPFCGRARV
190 200 210 220 230 240
HTDFTPSPYD RDSLKLQKGD VIQIVEKPPV GTWLGLLNGR MGSFKFIYVD VLPEEAVGPA
250 260 270 280 290 300
RPSRRQSKGK RPKPKTLHEL LERIGLEEHT STLLLNGYQT LEDFKELRET HLNELNIMDP
310 320 330 340 350 360
QHRAKLLTAA ELLLDYDTGS EEAEEGTESG QEPAVSTVAD PKVDIPRDSG CFEGSESGRD
370
EAELAGTEEQ LHGLSLSGAP