AiPD: Autoinhibited Protein Database

O75791

Gene name	GRAP2 (GADS, GRB2L, GRID)
Protein name	GRB2-related adapter protein 2
Names	Adapter protein GRID, GRB-2-like protein, GRB2L, GRBLG, GRBX, Grf40 adapter protein, Grf-40, Growth factor receptor-binding protein, Hematopoietic cell-associated adapter protein GrpL, P38, Protein GADS, SH3-SH2-SH3 adapter Mona
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9402
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

190-260 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

190-260 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for O75791

Entry ID	Method	Resolution	Chain	Position	Source
5GJH	X-ray	120 A	A/C	58-155	PDB
AF-O75791-F1	Predicted				AlphaFoldDB

270 variants for O75791

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	2	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs370483056 CA10245658	3	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA411968558 rs1428210175	4	V>I		No	ClinGen gnomAD
rs1478495061 CA411968575	6	K>M		No	ClinGen TOPMed
TCGA novel	6	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1569207663 CA411968585	7	F>L		No	ClinGen Ensembl
rs1473852918 CA411968593	8	D>E		No	ClinGen TOPMed
rs1180492684 CA411968586	8	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1366703601 CA411968590	8	D>V		No	ClinGen gnomAD
rs758775230 CA10245660	10	T>S		No	ClinGen ExAC gnomAD
rs1569207682 CA411968614	12	S>A		No	ClinGen Ensembl
rs1253255216 CA411968623	13	G>D		No	ClinGen TOPMed
CA411968626 rs1209490927	14	E>K		No	ClinGen TOPMed
rs1320961295 CA411968700	23	D>G		No	ClinGen gnomAD
CA10245661 rs150476109	26	K>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs975696602 CA324155358	30	N>S		No	ClinGen TOPMed
CA411969478 rs1463675269	31	Q>K		No	ClinGen gnomAD
CA411969496 rs1204390225	32	E>K		No	ClinGen TOPMed
CA411969578 rs1266490232	36	K>R		No	ClinGen TOPMed
CA10245686 rs371786533	37	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs775175089 CA10245688	40	G>E		No	ClinGen ExAC gnomAD
CA324155385 rs138281457	41	S>G		No	ClinGen ESP TOPMed gnomAD
TCGA novel	42	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1159751923 CA411969672	42	Q>R		No	ClinGen gnomAD
rs768481077 CA10245690	51	I>M		No	ClinGen ExAC gnomAD
TCGA novel	52	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1408106492 CA411969849	54	Q>*		No	ClinGen gnomAD
CA10245691 rs776445271	54	Q>L		No	ClinGen ExAC gnomAD
TCGA novel	55	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10245692 rs761669779	56	P>A		No	ClinGen ExAC gnomAD
CA10245693 rs765331882	56	P>R		No	ClinGen ExAC gnomAD
CA411970335 rs1296442281	61	E>G		No	ClinGen TOPMed
rs138713668 CA10245709	61	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1283251921 CA411970342	62	G>C		No	ClinGen gnomAD
CA411970349 rs1255710073	62	G>V		No	ClinGen gnomAD
rs1207999000 CA411970357	63	L>F		No	ClinGen gnomAD
rs1273085785 CA411970360	63	L>H		No	ClinGen gnomAD
rs748105252 CA10245711	64	S>C		No	ClinGen ExAC gnomAD
COSM3939657 CA324158531 rs974232489	65	R>*	oesophagus Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs769770976 CA10245712	66	H>Y		No	ClinGen ExAC gnomAD
TCGA novel	67	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411970428 rs1431039150	68	A>S		No	ClinGen gnomAD
rs1353740845 CA411970460	70	N>S		No	ClinGen gnomAD
rs918935168 CA324158543	71	L>F		No	ClinGen TOPMed gnomAD
rs1431387135 CA411970478	71	L>S		No	ClinGen TOPMed gnomAD
rs1166694576 CA411970486	72	L>F		No	ClinGen TOPMed gnomAD
CA411970485 rs1166694576	72	L>V		No	ClinGen TOPMed gnomAD
CA411970551 rs1429219429	75	K>N		No	ClinGen gnomAD
rs1370013563 CA411970562	76	E>G		No	ClinGen gnomAD
rs1294137329 CA411970555	76	E>K		No	ClinGen gnomAD
CA411970604 rs1420483012	79	F>C		No	ClinGen TOPMed
CA10245715 rs770988005	82	I>T		No	ClinGen ExAC gnomAD
CA411970662 rs1488265097	83	R>P		No	ClinGen TOPMed
rs774442868 CA10245716	84	A>G		No	ClinGen ExAC gnomAD
rs759767093 CA10245717	86	Q>E		No	ClinGen ExAC
rs767798258 CA10245718	89	P>S		No	ClinGen ExAC TOPMed gnomAD
rs753165418 CA10245719	90	G>A		No	ClinGen ExAC gnomAD
CA10245720 rs540420303	91	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA411970782 rs1217363736	91	D>V		No	ClinGen TOPMed
CA411970820 rs1288778423	94	I>V		No	ClinGen TOPMed
TCGA novel	99	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1465935051 CA411972118	100	D>G		No	ClinGen gnomAD
CA411972114 rs1260977466	100	D>N		No	ClinGen gnomAD
CA10245738 rs764493218	102	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1194310792 CA411972136	103	Q>*		No	ClinGen Ensembl
rs1183583196 CA411972183	109	R>*		No	ClinGen gnomAD
CA10245739 rs754398099	109	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1164117471 CA411972190	110	D>G		No	ClinGen gnomAD
rs372740629 CA10245740	112	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA411972219 rs1458959115	114	N>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs765826788 CA10245741	114	N>I		No	ClinGen ExAC TOPMed gnomAD
rs765826788 CA324163204	114	N>S		No	ClinGen ExAC TOPMed gnomAD
rs751130456 CA10245742	116	F>L		No	ClinGen ExAC gnomAD
TCGA novel	117	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1305153200 CA411972297	118	W>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs780881602 CA10245744	120	E>G		No	ClinGen ExAC gnomAD
rs1216928522 CA411972363	122	F>L		No	ClinGen TOPMed
CA10245746 rs755910417	123	P>L		No	ClinGen ExAC gnomAD
CA324163261 rs866441319	124	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs367728516 CA324163288	126	N>D		No	ClinGen ESP gnomAD
CA411972445 rs1324058465	127	K>N		No	ClinGen gnomAD
rs749209183 CA10245748	128	L>P		No	ClinGen ExAC gnomAD
CA411972450 rs1601743187	128	L>V		No	ClinGen Ensembl
rs1322329825 CA411972497	131	Y>C		No	ClinGen TOPMed
rs778689725 CA10245750	131	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs1181361069 CA411972504	132	Y>H		No	ClinGen gnomAD
TCGA novel	133	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1252720987 CA411972512	133	R>K		No	ClinGen gnomAD
TCGA novel	133	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs371510448 CA10245751	134	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA324163328 rs763676052	135	N>I		No	ClinGen Ensembl
TCGA novel	135	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775865688 CA10245753	136	S>C		No	ClinGen ExAC gnomAD
CA411972555 rs1178625972	140	Q>E		No	ClinGen TOPMed gnomAD
CA411972576 CA411972577 rs1372275780	142	Q>H		No	ClinGen gnomAD
rs1357940059 CA411972581	143	I>T		No	ClinGen TOPMed gnomAD
CA411972587 rs1447856000	144	F>V		No	ClinGen TOPMed gnomAD
rs1309166584 CA411972594	145	L>V		No	ClinGen gnomAD
rs267606253 CA324163354	146	R>K		No	ClinGen Ensembl
CA10245755 rs769173032	147	D>H		No	ClinGen ExAC gnomAD
rs769173032 CA10245756	147	D>N		No	ClinGen ExAC gnomAD
rs139269286 CA10245758	149	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10245757 rs139269286	149	T>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1009685469 CA324163373	150	R>*		No	ClinGen TOPMed
CA10245759 rs140074469	150	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA411972627 rs1426952536	151	E>K		No	ClinGen TOPMed
TCGA novel	152	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1569217901 CA411972782	154	G>D		No	ClinGen Ensembl
CA10245789 rs370853756	154	G>R		No	ClinGen ESP ExAC gnomAD
CA411972795 rs976111985	156	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA411972794 rs976111985	156	R>P		No	ClinGen TOPMed gnomAD
rs976111985 CA324164357	156	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs141126223 CA10245790 RCV000898353	156	R>W		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA10245792 rs576735893	157	G>S		No	ClinGen ExAC TOPMed gnomAD
CA411972810 rs1357197292	159	S>G		No	ClinGen gnomAD
rs146304501 CA10245793	159	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA10245794 rs748252804	159	S>R		No	ClinGen ExAC
rs376190713 CA411972828	162	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs374041033 CA10245798	162	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10245797 rs376190713	162	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA324164400 rs1051439606	165	Q>H		No	ClinGen TOPMed
rs989288073 CA411972848	165	Q>L		No	ClinGen TOPMed
CA324164390 rs989288073	165	Q>P		No	ClinGen TOPMed
CA411972853 rs1193162313	166	G>E		No	ClinGen gnomAD
rs915124071 CA324164403	167	G>S		No	ClinGen Ensembl
CA10245800 rs527418663	168	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs767989135 CA10245801	169	H>Q		No	ClinGen ExAC gnomAD
rs1160900890 CA411972875	170	L>F		No	ClinGen gnomAD
rs1412636409 CA411972880	171	S>G		No	ClinGen gnomAD
CA10245802 rs776346724	171	S>N		No	ClinGen ExAC gnomAD
CA411972890 rs1160919232	172	G>A		No	ClinGen gnomAD
rs1166412928 CA411972892	173	A>T		No	ClinGen gnomAD
rs1042322372 CA324164440	178	I>F		No	ClinGen Ensembl
CA10245805 rs750290967	179	R>*		No	ClinGen ExAC gnomAD
CA10245807 rs61752259	179	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10245806 rs61752259 RCV000880182	179	R>Q		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA411972936 rs1374099406	180	P>A		No	ClinGen TOPMed
CA324164451 rs939398261	181	S>A		No	ClinGen Ensembl
rs865901367 CA324164460	181	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA10245810 rs781093092	184	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA10245809 COSM187308 rs755090425	184	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA10245811 rs142712265	187	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs142712265 CA324164500	187	S>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA411972984 rs1257514391	188	D>H		No	ClinGen TOPMed gnomAD
rs919680021 CA324164517	189	H>P		No	ClinGen Ensembl
CA10245813 rs778028089	189	H>Q		No	ClinGen ExAC gnomAD
CA10245814 rs749722464	190	P>T		No	ClinGen ExAC gnomAD
CA411973006 rs1256270930	191	P>L		No	ClinGen gnomAD
TCGA novel	191	P>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	192	T>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs929679285 CA324164541	192	T>P		No	ClinGen Ensembl
rs1569218199 CA411973012	193	L>I		No	ClinGen Ensembl
CA411973020 rs1412376096	194	P>S		No	ClinGen TOPMed
rs994976457 CA324164578	196	Q>*		No	ClinGen TOPMed
CA411973047 rs1473614207	198	H>P		No	ClinGen TOPMed
rs912252231 CA324164596	200	H>P		No	ClinGen gnomAD
CA411973066 rs1456532185	200	H>Q		No	ClinGen TOPMed gnomAD
rs746302435 CA10245818	204	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1172894325 CA411973089	204	P>T		No	ClinGen gnomAD
rs768241861 CA10245819 COSM98280	205	P>L	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1300259602 CA411973103	206	Q>R		No	ClinGen TOPMed gnomAD
rs769370836 CA10245822	207	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1290478351 CA411973122	209	P>S		No	ClinGen gnomAD
CA411973131 rs1348805658	210	A>V		No	ClinGen TOPMed gnomAD
CA10245826 rs751579805	213	Q>R		No	ClinGen ExAC gnomAD
rs1347573041 CA411973175	217	P>A		No	ClinGen gnomAD
rs1338843312 CA411973179	217	P>L		No	ClinGen TOPMed
rs1347573041 CA411973176	217	P>S		No	ClinGen gnomAD
rs1347573041 CA411973174	217	P>T		No	ClinGen gnomAD
rs752763135 CA10245829	218	P>L		No	ClinGen ExAC gnomAD
CA10245828 rs767469099	218	P>S		No	ClinGen ExAC TOPMed gnomAD
rs867768593 CA324164623	219	Q>*		No	ClinGen Ensembl
rs35158049	219	Q>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1183659328 CA411973193	220	Q>*		No	ClinGen gnomAD
CA10245831 COSM3424191 rs180677935	221	R>*	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA324164653 rs1019235957	221	R>Q		No	ClinGen gnomAD
CA10245833 rs757618890	222	Y>F		No	ClinGen ExAC gnomAD
rs754006096 CA10245832	222	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA411973236 rs1172982555	226	H>Q		No	ClinGen gnomAD
rs746394148 CA10245835	227	H>Y		No	ClinGen ExAC gnomAD
CA324164671 rs893663722	229	H>Y		No	ClinGen TOPMed
CA10245856 rs780482218	231	E>D		No	ClinGen ExAC gnomAD
rs747491505 CA10245857	232	R>C		No	ClinGen ExAC TOPMed gnomAD
CA10245858 rs755717282	232	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1385472101 CA411973404	233	R>*		No	ClinGen gnomAD
rs777370081 CA10245859	233	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1366560121 CA411973411	234	G>A		No	ClinGen gnomAD
rs1387536267 CA411973446	239	I>M		No	ClinGen TOPMed gnomAD
CA10245860 rs748786613	239	I>V		No	ClinGen ExAC TOPMed gnomAD
CA10245862 rs774145468	243	H>Y		No	ClinGen ExAC gnomAD
rs374782136 CA10245864	244	C>G		No	ClinGen ExAC gnomAD
CA10245865 rs775298849	245	G>D		No	ClinGen ExAC TOPMed gnomAD
CA10245866 rs760617301	246	T>A		No	ClinGen ExAC TOPMed gnomAD
rs114611169 CA10245868 RCV000882788	247	G>S		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA324165624 rs935020882	250	S>G		No	ClinGen Ensembl
rs761847486 CA10245869	250	S>N		No	ClinGen ExAC gnomAD
CA411973516 rs1601747189	250	S>R		No	ClinGen Ensembl
TCGA novel	251	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750643624 COSM388161 CA10245871	254	A>V	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA411973563 rs1333275986	257	M>T		No	ClinGen gnomAD
rs766700141 CA10245873	258	H>R		No	ClinGen ExAC gnomAD
CA411973577 rs1164470654	259	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA411973589 rs1601747254	261	H>Y		No	ClinGen Ensembl
TCGA novel	263	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1389906842 CA411973617	265	V>L		No	ClinGen gnomAD
rs752029569 CA10245874	267	L>R		No	ClinGen ExAC gnomAD
CA411973640 rs1396121729	268	Q>H		No	ClinGen gnomAD
CA10245878 rs775800288	269	A>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA10245877 rs775800288	269	A>V		No	ClinGen ExAC TOPMed gnomAD
CA10245881 rs771799019	270	A>S		No	ClinGen ExAC TOPMed gnomAD
rs1268342773 CA411973656	271	G>V		No	ClinGen gnomAD
rs781122629 CA10245902	272	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10245903 rs748013074	272	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA10245905 rs544908309	273	V>M		No	ClinGen 1000Genomes ExAC gnomAD
rs774420692 CA10245908	274	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA10245907 rs187816875	274	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1335478207 CA411973690	276	A>P		No	ClinGen TOPMed
rs202203713 CA10245911	277	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs149718626 CA10245910	277	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs761211125 CA10245912	278	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1017228119 CA324166872	281	D>A		No	ClinGen Ensembl
CA411973730 rs1278574705	282	F>L		No	ClinGen gnomAD
CA411973739 rs1368091637	284	A>T		No	ClinGen gnomAD
rs1346989363 CA411973756	286	E>D		No	ClinGen gnomAD
CA411973760 rs1569220158	287	D>Y		No	ClinGen Ensembl
rs751156654 CA411973771	288	D>E		No	ClinGen ExAC TOPMed gnomAD
rs267606254 CA324166934	288	D>N		No	ClinGen Ensembl
CA411973773 rs1275531139	289	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs993197979 CA324166960	292	F>C		No	ClinGen Ensembl
CA411973792 rs1202758094	292	F>L		No	ClinGen gnomAD
CA324166968 rs891660620	293	H>R		No	ClinGen TOPMed gnomAD
rs568523300 CA10245919	293	H>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs777566631 CA10245922	295	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1169777491 CA411973839	296	E>A		No	ClinGen gnomAD
rs1440716177 CA411973838	296	E>Q		No	ClinGen TOPMed
CA324166983 rs904451886	297	V>M		No	ClinGen TOPMed
CA10245923 rs749440958	298	V>M		No	ClinGen ExAC gnomAD
rs1230594443 CA411973866	300	V>A		No	ClinGen TOPMed
CA411973862 rs770856671	300	V>I		No	ClinGen ExAC TOPMed gnomAD
CA10245924 rs770856671	300	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1293157995 CA411973898	305	N>S		No	ClinGen TOPMed
CA10245927 rs772583525	307	S>P		No	ClinGen ExAC gnomAD
TCGA novel	308	W>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776051445 CA10245928	308	W>S		No	ClinGen ExAC gnomAD
rs547943039 CA324167046	309	W>*		No	ClinGen 1000Genomes gnomAD
rs1299709569 CA411973932	310	T>N		No	ClinGen TOPMed gnomAD
rs1212836804 CA411973935	311	G>S		No	ClinGen gnomAD
rs147808667 CA10245930	312	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10245931 rs201778964 COSM1535447	312	R>H	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs201778964 CA324167082	312	R>L		No	ClinGen ExAC TOPMed gnomAD
rs147808667 CA411973942 COSM726245	312	R>S	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	314	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10245933 rs765742549	315	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1250405073 CA411973980	318	G>D		No	ClinGen gnomAD
VAR_012079 CA324167118 rs12759	319	L>F		No	ClinGen UniProt Ensembl dbSNP
CA10245936 rs767126287	320	F>L		No	ClinGen ExAC gnomAD
CA411974006 rs1166748581	322	A>V		No	ClinGen gnomAD
CA10245937 rs752554043	323	N>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	323	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755847534 CA10245938	324	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs1393524015 CA411974021	325	V>M		No	ClinGen TOPMed gnomAD
CA324167134 rs191967755	326	A>S		No	ClinGen 1000Genomes
CA10245941 rs757386785	327	P>T		No	ClinGen ExAC gnomAD
CA324167158 rs778341181	328	M>I		No	ClinGen TOPMed gnomAD
rs1428734954 CA411974039	328	M>K		No	ClinGen TOPMed gnomAD
CA411974040 rs1428734954	328	M>T		No	ClinGen TOPMed gnomAD
rs745916151 CA10245943	328	M>V		No	ClinGen ExAC gnomAD
CA10245944 rs772467549	330	R>*		No	ClinGen ExAC TOPMed gnomAD
CA10245945 rs775853641	330	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA10245946 rs747468628	331	R>K		No	ClinGen ExAC gnomAD

No associated diseases with O75791

4 regional properties for O75791

Type	Name	Position	InterPro Accession
domain	SH2 domain	56 - 149	IPR000980
domain	SH3 domain	1 - 56	IPR001452-1
domain	SH3 domain	271 - 330	IPR001452-2
domain	GRAP2, C-terminal SH3 domain	275 - 327	IPR035646

Functions

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm Endosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endosome	A vacuole to which materials ingested by endocytosis are delivered.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name	Definition
phosphotyrosine residue binding	Binding to a phosphorylated tyrosine residue within a protein.

4 GO annotations of biological process

Name	Definition
cell-cell signaling	Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
Ras protein signal transduction	The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
regulation of MAPK cascade	Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A6QLK6	GRAP	GRB2-related adapter protein	Bos taurus (Bovine)	PR
Q07883	GRB2	Growth factor receptor-bound protein 2	Gallus gallus (Chicken)	PR
O89100	Grap2	GRB2-related adaptor protein 2	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MEAVAKFDFT	ASGEDELSFH	TGDVLKILSN	QEEWFKAELG	SQEGYVPKNF	IDIQFPKWFH
70	80	90	100	110	120
EGLSRHQAEN	LLMGKEVGFF	IIRASQSSPG	DFSISVRHED	DVQHFKVMRD	NKGNYFLWTE
130	140	150	160	170	180
KFPSLNKLVD	YYRTNSISRQ	KQIFLRDRTR	EDQGHRGNSL	DRRSQGGPHL	SGAVGEEIRP
190	200	210	220	230	240
SMNRKLSDHP	PTLPLQQHQH	QPQPPQYAPA	PQQLQQPPQQ	RYLQHHHFHQ	ERRGGSLDIN
250	260	270	280	290	300
DGHCGTGLGS	EMNAALMHRR	HTDPVQLQAA	GRVRWARALY	DFEALEDDEL	GFHSGEVVEV
310	320
LDSSNPSWWT	GRLHNKLGLF	PANYVAPMTR