A6QLK6
PR
Gene name |
GRAP |
Protein name |
GRB2-related adapter protein |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:534491 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A6QLK6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A6QLK6-F1 | Predicted | AlphaFoldDB |
92 variants for A6QLK6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs466787891 | 3 | S>P | No | EVA | |
| rs449080387 | 7 | Y>F | No | EVA | |
| rs467614603 | 12 | T>P | No | EVA | |
| rs437919310 | 12 | T>R | No | EVA | |
| rs467614603 | 12 | T>S | No | EVA | |
| rs465403862 | 14 | S>G | No | EVA | |
| rs454175224 | 15 | D>Y | No | EVA | |
| rs442959461 | 26 | K>R | No | EVA | |
| rs480107695 | 53 | I>T | No | EVA | |
| rs41911764 | 55 | L>V | No | EVA | |
| rs438602312 | 60 | W>C | No | EVA | |
| rs478005599 | 60 | W>G | No | EVA | |
| rs460410246 | 61 | Y>S | No | EVA | |
| rs478935905 | 65 | I>F | No | EVA | |
| rs449286640 | 72 | E>Q | No | EVA | |
| rs467815455 | 73 | I>S | No | EVA | |
| rs483093670 | 74 | L>V | No | EVA | |
| rs450124055 | 76 | K>Q | No | EVA | |
| rs465435705 | 79 | H>P | No | EVA | |
| rs465435705 | 79 | H>R | No | EVA | |
| rs432530936 | 80 | Q>R | No | EVA | |
| rs454272624 | 83 | F>L | No | EVA | |
| rs466286982 | 85 | I>M | No | EVA | |
| rs473556072 | 93 | G>A | No | EVA | |
| rs456180192 | 95 | F>C | No | EVA | |
| rs444002809 | 95 | F>V | No | EVA | |
| rs441539265 | 103 | D>Y | No | EVA | |
| rs459974597 | 106 | Q>* | No | EVA | |
| rs478624958 | 109 | K>N | No | EVA | |
| rs448866873 | 110 | V>G | No | EVA | |
| rs461052732 | 111 | L>R | No | EVA | |
| rs482665506 | 112 | R>S | No | EVA | |
| rs477224370 | 113 | D>E | No | EVA | |
| rs449695465 | 113 | D>H | No | EVA | |
| rs465208251 | 113 | D>V | No | EVA | |
| rs447572389 | 122 | E>Q | No | EVA | |
| rs465869439 | 126 | N>Y | No | EVA | |
| rs436365532 | 127 | S>A | No | EVA | |
| rs454730153 | 138 | T>P | No | EVA | |
| rs470007396 | 138 | T>S | No | EVA | |
| rs471231568 | 142 | K>Q | No | EVA | |
| rs441362727 | 142 | K>R | No | EVA | |
| rs475258838 | 145 | Q>* | No | EVA | |
| rs442445065 | 146 | V>A | No | EVA | |
| rs442445065 | 146 | V>D | No | EVA | |
| rs442445065 | 146 | V>G | No | EVA | |
| rs460987354 | 148 | L>P | No | EVA | |
| rs482604008 | 150 | D>A | No | EVA | |
| rs443346363 | 152 | E>G | No | EVA | |
| rs458551839 | 153 | P>H | No | EVA | |
| rs1117570572 | 155 | P>S | No | EVA | |
| rs473187114 | 157 | P>R | No | EVA | |
| rs440371831 | 158 | P>A | No | EVA | |
| rs455607253 | 158 | P>R | No | EVA | |
| rs474216227 | 159 | R>G | No | EVA | |
| rs444390090 | 161 | C>G | No | EVA | |
| rs444390090 | 161 | C>R | No | EVA | |
| rs463023454 | 161 | C>W | No | EVA | |
| rs471862651 | 162 | F>L | No | EVA | |
| rs460618474 | 163 | A>G | No | EVA | |
| rs438878843 | 163 | A>P | No | EVA | |
| rs449521854 | 164 | Q>H | No | EVA | |
| rs478995202 | 164 | Q>L | No | EVA | |
| rs480288607 | 166 | Q>H | No | EVA | |
| rs461450624 | 166 | Q>L | No | EVA | |
| rs461450624 | 166 | Q>P | No | EVA | |
| rs450420839 | 167 | F>C | No | EVA | |
| rs468950071 | 168 | D>E | No | EVA | |
| rs432910493 | 169 | F>C | No | EVA | |
| rs444878326 | 169 | F>L | No | EVA | |
| rs797125744 | 170 | S>L | No | EVA | |
| rs466799007 | 170 | S>P | No | EVA | |
| rs455646359 | 173 | D>G | No | EVA | |
| rs474054006 | 177 | L>R | No | EVA | |
| rs437988221 | 180 | R>G | No | EVA | |
| rs456563627 | 186 | E>K | No | EVA | |
| rs438918823 | 188 | L>M | No | EVA | |
| rs460455054 | 192 | D>A | No | EVA | |
| rs442943739 | 193 | P>R | No | EVA | |
| rs472627477 | 193 | P>S | No | EVA | |
| rs472627477 | 193 | P>T | No | EVA | |
| rs1116841881 | 199 | R>Q | No | EVA | |
| rs483341824 | 202 | G>W | No | EVA | |
| rs466637380 | 209 | R>G | No | EVA | |
| rs433774469 | 210 | S>G | No | EVA | |
| rs449055383 | 213 | Q>P | No | EVA | |
| rs456350935 | 215 | V>G | No | EVA | |
| rs471835906 | 216 | H>N | No | EVA | |
| rs432344436 | 216 | H>P | No | EVA | |
| rs454093088 | 217 | M>I | No | EVA | |
| rs472463250 | 218 | M>G | No | EVA | |
| rs442980604 | 218 | M>W | No | EVA |
No associated diseases with A6QLK6
4 regional properties for A6QLK6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SH2 domain | 58 - 158 | IPR000980 |
| domain | SH3 domain | 1 - 58 | IPR001452-1 |
| domain | SH3 domain | 158 - 217 | IPR001452-2 |
| domain | GRAP, N-terminal SH3 domain | 2 - 55 | IPR035645 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| COP9 signalosome | A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| presynapse | The part of a synapse that is part of the presynaptic cell. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| epidermal growth factor receptor binding | Binding to an epidermal growth factor receptor. |
| phosphotyrosine residue binding | Binding to a phosphorylated tyrosine residue within a protein. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of MAPK cascade | Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. |
| sensory perception of sound | The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESVALYSFQ | ATESDELAFN | KGDTLKILNM | EDDQNWYKAE | LRGAEGFVPK | NYIRLKPHPW |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YSGRISRQLA | EEILMKRNHQ | GAFLIRESES | SPGEFSVSVN | YGDQVQHFKV | LRDPSGKYYL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WEEKFNSLNE | LVAFYRTTTI | AKKRQVFLQD | EEPLPKPPRA | CFAQAQFDFS | AQDPSQLSFR |
| 190 | 200 | 210 | |||
| RGDIIEVLER | LDPSWWRGRL | SGRIGFFPRS | YVQPVHM |