AiPD: Autoinhibited Protein Database

Gene name	Cpsf2 (Cpsf100, Mcpsf)
Protein name	Cleavage and polyadenylation specificity factor subunit 2
Names	Cleavage and polyadenylation specificity factor 100 kDa subunit, CPSF 100 kDa subunit
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:51786
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

381-455 (Predicted disordered autoinhibitory region) PR

381-455 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O35218-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389258531	28	F>C	No	EVA
rs3389187287	69	G>V	No	EVA
rs3389254106	89	P>L	No	EVA
rs3389215709	93	M>L	No	EVA
rs3389228530	113	L>F	No	EVA
rs3389256722	120	D>E	No	EVA
rs3389256645	158	T>S	No	EVA
rs3389252001	207	Y>H	No	EVA
rs3389254381	220	L>P	No	EVA
rs3389266200	221	T>R	No	EVA
rs3389263476	233	V>M	No	EVA
rs3389258465	235	I>V	No	EVA
rs3389266260	250	L>M	No	EVA
rs3389254392	251	D>N	No	EVA
rs3389258504	299	R>G	No	EVA
rs3389271369	334	E>D	No	EVA
rs3389258511	350	K>*	No	EVA
rs3389254031	358	R>K	No	EVA
rs3389271318	399	E>*	No	EVA
rs3389256647	403	K>R	No	EVA
rs3389266234	601	S>G	No	EVA
rs3389215669	606	Y>F	No	EVA
rs3389258520	614	L>F	No	EVA
rs3389257253	646	V>A	No	EVA
rs3403655571	675	Q>L	No	EVA
rs3403564846	676	Q>L	No	EVA
rs3389266204	688	K>N	No	EVA
rs3389258505	694	T>I	No	EVA
rs3389271312	728	L>P	No	EVA
rs3389257208	739	G>W	No	EVA
rs3389215694	774	L>P	No	EVA
rs3389258502	779	Y>F	No	EVA

Type	Name	Position	InterPro Accession
domain	Metallo-beta-lactamase	22 - 198	IPR001279
domain	Zn-dependent metallo-hydrolase, RNA specificity domain	529 - 591	IPR011108
domain	Beta-Casp domain	243 - 368	IPR022712
domain	Cleavage and polyadenylation specificity factor 2, C-terminal	608 - 779	IPR025069
domain	CPSF2, metallo-hydrolase domain	7 - 204	IPR035639

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
mRNA cleavage and polyadenylation specificity factor complex	A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal.

Name	Definition
RNA binding	Binding to an RNA molecule or a portion thereof.

Name	Definition
mRNA 3'-end processing by stem-loop binding and cleavage	Any mRNA 3'-end processing that involves the binding to and cleavage of a stem-loop structure. For example, histone mRNAs contain a highly conserved stem-loop sequence at the 3' end of the mRNA with a 6 base pairs (bp) stem and a 4-nt loop. The mRNA is cleaved between these two elements, after the fourth or fifth nucleotide, which is typically an adenosine.
mRNA polyadenylation	The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.
pre-mRNA cleavage required for polyadenylation	The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q12102	CFT2	Cleavage factor two protein 2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q9V3D6	Cpsf100	Probable cleavage and polyadenylation specificity factor subunit 2	Drosophila melanogaster (Fruit fly)	PR
Q9P2I0	CPSF2	Cleavage and polyadenylation specificity factor subunit 2	Homo sapiens (Human)	PR
O17403	cpsf-2	Probable cleavage and polyadenylation specificity factor subunit 2	Caenorhabditis elegans	PR