AiPD: Autoinhibited Protein Database

O14576

Gene name	DYNC1I1 (DNCI1, DNCIC1)
Protein name	Cytoplasmic dynein 1 intermediate chain 1
Names	Cytoplasmic dynein intermediate chain 1, Dynein intermediate chain 1, cytosolic, DH IC-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:1780
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

66-212 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

66-212 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for O14576

Entry ID	Method	Resolution	Chain	Position	Source
AF-O14576-F1	Predicted				AlphaFoldDB

444 variants for O14576

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA4352086 rs749605007	4	K>R		No	ClinGen ExAC gnomAD
rs1315133724 CA368403337	10	E>G		No	ClinGen gnomAD
TCGA novel	12	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1237310197 CA368403356	13	R>C		No	ClinGen gnomAD
CA163471970 rs868588293	13	R>H		No	ClinGen gnomAD
TCGA novel	13	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368403363 rs1180374856	14	K>R		No	ClinGen gnomAD
rs760252944 CA4352092	17	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
COSM198761 rs1378425188 CA368403385	17	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs763887544 CA4352093	20	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA368403403 rs1399566810	20	Q>K		No	ClinGen gnomAD
rs1464211700 CA368403413	21	I>M		No	ClinGen gnomAD
rs753702370 CA4352094	21	I>V		No	ClinGen ExAC gnomAD
TCGA novel	25	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA163472033 rs62639694	26	K>N		No	ClinGen Ensembl
CA4352096 rs555557277	27	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs756972511 CA4352095	27	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1562899885 CA368403458	28	K>M		No	ClinGen Ensembl
TCGA novel	31	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1317706919 CA368403480	31	E>Q		No	ClinGen gnomAD
CA163472043 rs976343566	34	K>M		No	ClinGen TOPMed
CA4352097 rs750279713	35	K>R		No	ClinGen ExAC gnomAD
CA4352116 rs200845264	37	A>S		No	ClinGen ExAC TOPMed gnomAD
CA4352117 rs752893858	39	M>I		No	ClinGen ExAC gnomAD
rs1391281994 CA368403554	39	M>R		No	ClinGen TOPMed
CA368403562 rs1470799926	40	Q>R		No	ClinGen gnomAD
rs756229765 CA4352118	41	Q>H		No	ClinGen ExAC gnomAD
TCGA novel	42	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757671459 CA4352121	46	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4352122 rs76250658	47	Q>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA163474424 rs565417352	48	D>N		No	ClinGen 1000Genomes
rs772623334 CA4352124	49	D>N		No	ClinGen ExAC TOPMed gnomAD
CA368403625 rs1346289011	49	D>V		No	ClinGen gnomAD
COSM1755442 CA163474446 rs780509560	54	R>C	large_intestine Variant assessed as Somatic; impact. urinary_tract [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA4352125 rs780509560	54	R>G		No	ClinGen ExAC TOPMed gnomAD
rs377495263 CA4352126	54	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1584243902 CA368403667	56	R>*		No	ClinGen Ensembl
rs1435212532 CA368403669	56	R>Q		No	ClinGen gnomAD
rs768106213 CA4352127	57	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA368403681 rs776377255 CA4352128	58	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1258717707 CA368403677	58	E>Q		No	ClinGen TOPMed
rs1322212612 CA368403682	59	T>P		No	ClinGen TOPMed
CA368403693 rs1357229076	60	E>A		No	ClinGen TOPMed gnomAD
rs1584243961 CA368403695	60	E>D		No	ClinGen Ensembl
rs1357229076 CA368403691	60	E>G		No	ClinGen TOPMed gnomAD
CA368403688 rs1584243949 COSM602647	60	E>K	lung [Cosmic]	No	ClinGen cosmic curated Ensembl
CA368403707 CA4352129 rs371217689	62	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel rs1584243987 CA368403710	63	L>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
CA368403744 rs1490713800	68	I>V		No	ClinGen gnomAD
CA4352131 rs772941982	69	S>*		No	ClinGen ExAC
CA368403749 rs1584243995	69	S>P		No	ClinGen Ensembl
rs762840556 CA4352132	70	P>A		No	ClinGen ExAC TOPMed gnomAD
CA368403757 rs1290513664	70	P>L		No	ClinGen Ensembl
CA4352133 rs762840556	70	P>S		No	ClinGen ExAC TOPMed gnomAD
CA4352135 rs760856913	72	P>L		No	ClinGen ExAC gnomAD
CA368403782 rs1287433659	75	V>M		No	ClinGen TOPMed
RCV000905294 rs117676704 CA4352150	76	Q>E		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA368402702 rs1209559922	76	Q>R		No	ClinGen gnomAD
COSM198763 CA4352153 rs199740432	77	P>L	large_intestine endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA368402708 rs199740432	77	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA4352152 rs759479007	77	P>T		No	ClinGen ExAC gnomAD
rs761947806 CA4352155	78	L>R		No	ClinGen ExAC gnomAD
CA368402716 rs1459297377	79	H>Y		No	ClinGen TOPMed
rs781167095	81	L>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781167095	81	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs374055417 CA4352158	83	W>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA4352159 rs758793823	84	D>H		No	ClinGen ExAC TOPMed gnomAD
CA4352160 rs780331670	85	T>A		No	ClinGen ExAC gnomAD
CA4352162 rs755499651	87	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA4352163 rs781721654	91	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1584246436 CA368402821	94	T>P		No	ClinGen Ensembl
rs1307153884 CA368402825	94	T>S		No	ClinGen TOPMed
CA4352164 rs747655707 CA368402839	96	M>I		No	ClinGen ExAC TOPMed gnomAD
CA163484765 rs200318990	96	M>V		No	ClinGen Ensembl
rs990703133 CA163484766	97	S>C		No	ClinGen Ensembl
COSM3412516 CA4352166 rs532833915	100	S>L	central_nervous_system [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
CA4352169 rs367583220	101	K>R		No	ClinGen ESP ExAC
rs1319877361 CA368402895	106	P>T		No	ClinGen gnomAD
CA368402917 rs1404153382	109	A>T		No	ClinGen TOPMed
CA4352170 rs745644201	110	G>E		No	ClinGen ExAC TOPMed gnomAD
rs771968569 CA4352171	113	D>E		No	ClinGen ExAC TOPMed gnomAD
CA368402944 rs1465516789	113	D>N		No	ClinGen TOPMed
TCGA novel	114	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	114	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765322548 CA4352175	116	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs765322548 CA4352174	116	D>Y		No	ClinGen ExAC gnomAD
CA368402982 rs1161558300	119	P>A		No	ClinGen gnomAD
rs999992062 CA163486208	124	L>P		No	ClinGen Ensembl
rs750054458 CA4352223	128	T>P		No	ClinGen ExAC gnomAD
CA4352224 rs758134937	134	Q>*		No	ClinGen ExAC gnomAD
rs1289154946 CA368403183	134	Q>R		No	ClinGen gnomAD
rs1584258028 CA368403203	137	S>L		No	ClinGen Ensembl
TCGA novel	140	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1361679659	141	L>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368403829 rs1291931443	147	K>E		No	ClinGen TOPMed
rs1449377026 CA368403845	149	G>D		No	ClinGen gnomAD
rs201114371 CA4352243 COSM2150542	150	V>M	Variant assessed as Somatic; 0.0 impact. central_nervous_system breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA4352244 rs146559643	152	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA368403861 rs1219432726	152	K>M		No	ClinGen TOPMed
TCGA novel	154	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1276630315 CA368403870	154	T>S		No	ClinGen TOPMed
CA368403883 rs3757697	155	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA368403889 rs1221956307	156	V>A		No	ClinGen gnomAD
CA368403890 rs1312627921	157	D>N		No	ClinGen gnomAD
CA4352247 rs142483580	158	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs267601651 CA368403903	158	F>L		No	ClinGen Ensembl
rs1018082393 CA163490430	162	E>V		No	ClinGen TOPMed gnomAD
rs755268981 CA163490431	163	V>E		No	ClinGen TOPMed gnomAD
rs755268981 CA368403934	163	V>G		No	ClinGen TOPMed gnomAD
CA368403931 rs1480000088	163	V>L		No	ClinGen gnomAD
CA368403956 rs1389339925	167	S>P		No	ClinGen TOPMed
CA368403963 rs1478565664	168	K>Q		No	ClinGen TOPMed
CA368403969 rs1253400339	169	E>K		No	ClinGen gnomAD
TCGA novel	171	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368404004 rs1479241308	174	L>V		No	ClinGen gnomAD
CA368404010 rs1175334333	175	A>T		No	ClinGen gnomAD
rs748035438 CA4352248	176	T>A		No	ClinGen ExAC
CA4352249 rs369627655 COSM1313450	176	T>M	Variant assessed as Somatic; 4.624e-05 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs775544140 CA4352253	177	H>R		No	ClinGen ExAC TOPMed gnomAD
rs772404533 CA4352252	177	H>Y	Variant assessed as Somatic; 4.625e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA368404036 rs1441516909	179	S>F		No	ClinGen gnomAD
rs762550680 CA4352280	182	D>V		No	ClinGen ExAC gnomAD
rs1584218755 CA368404102	186	E>K		No	ClinGen Ensembl
CA368404123 rs1449248287	188	M>I		No	ClinGen gnomAD
rs765771171 CA4352281	188	M>T		No	ClinGen ExAC gnomAD
CA4352282 rs370031174	190	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	191	S>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1392594191 CA368404157	193	V>A		No	ClinGen gnomAD
rs1562961395 CA368404153	193	V>I		No	ClinGen Ensembl
CA4352283 rs202183816	194	G>D		No	ClinGen 1000Genomes ExAC gnomAD
rs202183816 CA4352284	194	G>V		No	ClinGen 1000Genomes ExAC gnomAD
RCV000882688 CA4352286 rs35314029	199	L>M		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA368404201 rs1407285773	200	E>G		No	ClinGen gnomAD
CA368404219 rs1435554854	202	Q>H		No	ClinGen gnomAD
rs1316589653 CA368404213	202	Q>K		No	ClinGen gnomAD
CA4352287 rs141450323	202	Q>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA163501822 rs753670141	203	D>E		No	ClinGen ExAC TOPMed gnomAD
CA368404220 rs1322402297	203	D>N		No	ClinGen gnomAD
TCGA novel	205	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs190596245 COSM1580841 CA4352289	205	K>R	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA368404242 rs1183836707	206	Q>K		No	ClinGen gnomAD
TCGA novel	206	Q>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779940439 CA368404256 CA4352290	207	E>D		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	209	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761715318 CA4352309	212	P>L		No	ClinGen ExAC gnomAD
CA368404306 rs1303656370	213	P>L		No	ClinGen TOPMed
CA163502573 rs61750840	221	K>N		No	ClinGen Ensembl
rs755089840 CA368404367	222	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs755089840 CA4352312	222	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA4352313 rs781589500	222	Q>R		No	ClinGen ExAC gnomAD
CA368404376 rs1161721009	223	Q>R		No	ClinGen gnomAD
CA4352315 rs756508694	224	I>S		No	ClinGen ExAC TOPMed gnomAD
CA4352314 rs752932291	224	I>V		No	ClinGen ExAC TOPMed gnomAD
rs17853120 CA163502574	225	L>I		No	ClinGen gnomAD
CA163502575 rs17854816	227	S>L		No	ClinGen Ensembl
rs373488262 CA4352316	227	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	228	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4352319 rs771404853	233	F>L		No	ClinGen ExAC gnomAD
rs779358338 CA4352320	233	F>S		No	ClinGen ExAC
CA163502577 rs981208301	235	D>N		No	ClinGen TOPMed
rs553629207 CA4352322	236	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4352321 rs745430386	236	R>W		No	ClinGen ExAC TOPMed gnomAD
CA4352325 rs573158000	239	R>L		No	ClinGen 1000Genomes ExAC gnomAD
CA4352324 rs573158000	239	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
COSM485768 CA4352323 rs775154382	239	R>W	kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1233008032 CA368404488	241	I>T		No	ClinGen gnomAD
rs967856152 CA163502581	246	A>T		No	ClinGen TOPMed
rs776357212 CA4352326	247	E>Q		No	ClinGen ExAC gnomAD
CA368404533 rs1273990745	248	D>G		No	ClinGen gnomAD
CA368404543 rs750340243	250	D>H		No	ClinGen ExAC TOPMed gnomAD
CA4352329 COSM236092 rs750340243	250	D>N	autonomic_ganglia [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs759723321 CA4352330	251	I>T		No	ClinGen ExAC gnomAD
TCGA novel	254	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767642269 CA4352331	256	S>G		No	ClinGen ExAC gnomAD
CA163502583 rs867342892	257	G>D		No	ClinGen Ensembl
rs187401312 CA163502582	257	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA TOPMed
CA368404600 rs1379204269	258	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs756345512 CA4352333	258	R>L		No	ClinGen ExAC TOPMed gnomAD
rs756345512 CA368404601	258	R>P		No	ClinGen ExAC TOPMed gnomAD
rs756345512 CA4352334	258	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs139485962 CA368404608	259	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA163502585 rs139501133	261	E>D		No	ClinGen ESP TOPMed
CA163502586 rs1049129897	263	K>E		No	ClinGen TOPMed gnomAD
TCGA novel	264	D>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	265	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754041257 CA4352353	267	V>I		No	ClinGen ExAC TOPMed gnomAD
rs754041257 CA4352354	267	V>L		No	ClinGen ExAC TOPMed gnomAD
rs767955809 CA4352355	269	A>P		No	ClinGen ExAC TOPMed gnomAD
rs767955809 CA4352356	269	A>T		No	ClinGen ExAC TOPMed gnomAD
rs758971443 CA4352357	270	G>A		No	ClinGen ExAC gnomAD
CA163502820 rs946567842	271	A>P		No	ClinGen TOPMed gnomAD
CA368404702 rs1413621238	272	N>S		No	ClinGen TOPMed
CA368404700 rs1248451014	272	N>Y		No	ClinGen gnomAD
rs1207673826 CA368404720	275	F>V		No	ClinGen gnomAD
CA368404726 rs1466178962	276	N>H		No	ClinGen gnomAD
CA4352358 rs780509369	276	N>S		No	ClinGen ExAC TOPMed gnomAD
CA163502821 rs905324043	277	R>C		No	ClinGen TOPMed gnomAD
CA368404735 COSM3412517 rs1423892270	277	R>H	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA4352359 rs746551909	280	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA368404791 rs17856963	284	W>*		No	ClinGen TOPMed
CA163502822 rs17856963	284	W>C		No	ClinGen TOPMed
rs773523453 CA368404805	286	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1420279332 CA368404807	287	H>N		No	ClinGen TOPMed
rs780741652 CA4352361	287	H>R		No	ClinGen ExAC gnomAD
CA163502823 rs952756652 COSM1250832	288	R>Q	oesophagus [Cosmic]	No	ClinGen cosmic curated Ensembl
CA368404821 rs1389913979	289	V>E		No	ClinGen gnomAD
CA4352363 rs769728537	290	V>A		No	ClinGen ExAC gnomAD
rs749086223 CA368404858	294	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1315054045 CA368404868	295	W>C		No	ClinGen gnomAD
TCGA novel	298	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368404905 rs1205359749	299	Y>N		No	ClinGen gnomAD
rs761851293 CA4352388	302	L>M		No	ClinGen ExAC gnomAD
rs113497451 CA163503806	302	L>P		No	ClinGen Ensembl
CA368404943 rs1189815760	305	A>T		No	ClinGen TOPMed gnomAD
rs1424963572 CA368404964	308	N>D		No	ClinGen gnomAD
CA163503807 rs984073740	308	N>S		No	ClinGen TOPMed gnomAD
CA4352391 rs143419715	309	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs143419715 CA4352390	309	N>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs766702267 CA4352392	310	N>S		No	ClinGen ExAC gnomAD
rs1308814614 CA368404994	312	D>G		No	ClinGen gnomAD
CA368405008 rs1434645342	314	P>L		No	ClinGen gnomAD
rs760151211 CA4352394	314	P>T		No	ClinGen ExAC gnomAD
rs1432681942 CA368405013	315	H>P		No	ClinGen TOPMed
rs771966085 CA163503808	316	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs767909436 CA4352395	317	P>R		No	ClinGen ExAC gnomAD
CA368405038 rs1294517026	319	G>R		No	ClinGen Ensembl
rs147131803 CA4352396	320	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs755660076 CA4352397	323	V>A		No	ClinGen ExAC gnomAD
CA4352398 rs777588095	325	N>S		No	ClinGen ExAC gnomAD
CA368405084 rs1449496409	326	M>V		No	ClinGen gnomAD
rs1274437633 CA368405096	327	K>M		No	ClinGen TOPMed
TCGA novel	328	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1246486867 CA368405125	331	T>P		No	ClinGen gnomAD
CA368405154 rs1195987180	335	Y>C		No	ClinGen gnomAD
CA4352403 rs148644569	336	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA368405158 rs148644569	336	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA163503809 rs922727922	337	F>L		No	ClinGen TOPMed
rs532466715 CA163503810	338	H>R		No	ClinGen Ensembl
TCGA novel	341	S>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	343	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368405226 rs750281458	344	M>R		No	ClinGen ExAC gnomAD
rs750281458 CA4352425	344	M>T		No	ClinGen ExAC gnomAD
rs1381436803 COSM1453045 CA368405235	345	S>L	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
COSM3431907 CA4352429 rs756202767	349	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA
rs17853779 CA4352430	350	R>C		No	ClinGen ExAC TOPMed gnomAD
rs17853779 CA163507180	350	R>G		No	ClinGen ExAC TOPMed gnomAD
COSM171431 CA4352431 rs376275541	350	R>H	lung Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs774410304 CA4352433	352	H>R		No	ClinGen ExAC TOPMed gnomAD
CA4352434 rs746262928	353	P>S		No	ClinGen ExAC gnomAD
rs1207515046 CA368405313	358	G>S		No	ClinGen TOPMed gnomAD
rs772281540 CA368405328	360	T>N		No	ClinGen ExAC TOPMed gnomAD
rs772281540 CA4352435	360	T>S		No	ClinGen ExAC TOPMed gnomAD
CA368405331 rs1328911448	361	Y>H		No	ClinGen gnomAD
rs776143490 CA4352436	362	S>*		No	ClinGen ExAC gnomAD
CA163507181 rs776143490	362	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs954536370 CA163507182	363	G>D		No	ClinGen Ensembl
rs1440731310 CA368405353 CA368405354	364	Q>H		No	ClinGen gnomAD
TCGA novel	366	V>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs78731424 CA163507183	367	L>I		No	ClinGen Ensembl
CA368405378 rs913296254	368	W>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs913296254 CA163507184	368	W>C		No	ClinGen TOPMed gnomAD
CA4352438 rs764683489	368	W>L		No	ClinGen ExAC gnomAD
CA368405380 rs1476299974	369	D>N		No	ClinGen gnomAD
CA368405398 rs1180379367	371	R>H		No	ClinGen TOPMed gnomAD
rs902089808 CA163507185	371	R>S		No	ClinGen TOPMed
VAR_064709	373	H>L	found in a renal cell carcinoma case; somatic mutation [UniProt]	No	UniProt
COSM2149518 CA4352439 rs776347302	374	R>*	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA4352440 rs761198234	375	R>G		No	ClinGen ExAC gnomAD
CA4352441 rs764966313	376	T>A		No	ClinGen ExAC gnomAD
rs372905393 CA4352442	376	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA4352443 rs758219234	378	V>M		No	ClinGen ExAC gnomAD
CA368405452 rs1356888200	380	R>Q		No	ClinGen TOPMed gnomAD
CA368405462 rs1200744202	382	P>A		No	ClinGen gnomAD
rs546629907 COSM169788 CA4352444	389	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
TCGA novel	391	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1275980376 CA368405535	391	P>S		No	ClinGen gnomAD
CA4352458 rs761416597	392	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4352459 rs764584111	393	Y>H		No	ClinGen ExAC gnomAD
rs772928673 CA4352460	394	C>R		No	ClinGen ExAC gnomAD
rs375017615 CA4352461	398	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA368405598 rs1264919661	401	Q>L		No	ClinGen gnomAD
rs751391959 CA4352463	412	D>A		No	ClinGen ExAC gnomAD
CA4352464 rs754740631	413	G>S		No	ClinGen ExAC gnomAD
CA368405725 rs777230119	419	S>I		No	ClinGen TOPMed
rs777230119 CA163507618	419	S>N		No	ClinGen TOPMed
rs1463192047 CA368405727	419	S>R		No	ClinGen gnomAD
CA4352465 rs767469710	420	L>M		No	ClinGen ExAC gnomAD
CA163507620 rs1022301551	422	M>T		No	ClinGen Ensembl
CA4352466 rs752540598	422	M>V		No	ClinGen ExAC gnomAD
rs368505837 CA4352467	425	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA368405799 rs1362691830	429	S>G		No	ClinGen gnomAD
CA368405801 rs1384024941	429	S>N		No	ClinGen TOPMed gnomAD
rs763506880 CA4352483	430	M>V		No	ClinGen ExAC gnomAD
CA163507912 rs759929869	431	E>V		No	ClinGen Ensembl
CA368405833 rs1562980047	434	Y>H		No	ClinGen Ensembl
CA368405841 rs1274805310	435	N>D		No	ClinGen gnomAD
rs760589743 CA4352485	435	N>S		No	ClinGen ExAC gnomAD
rs1268721723 CA368405865	438	K>R		No	ClinGen gnomAD
rs1486540291 CA368405870	439	P>A		No	ClinGen gnomAD
CA4352486 rs764090165	439	P>R		No	ClinGen ExAC gnomAD
rs375862083 COSM1739411 CA4352489	441	A>S	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA368405880 rs375862083 COSM3412518	441	A>T	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1189711732 CA368405886	442	V>I		No	ClinGen gnomAD
rs781466179 CA4352492	444	G>E		No	ClinGen ExAC gnomAD
CA4352491 rs755406657	444	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1562980117 CA368405902	445	M>V		No	ClinGen Ensembl
TCGA novel	447	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368405929 rs1367770806	448	P>L		No	ClinGen TOPMed
rs370220914 CA4352493	449	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1401669771 CA368405944	451	D>G		No	ClinGen gnomAD
CA4352496 rs748814410	452	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	454	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	455	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368405978 COSM3412519 rs1227595850	456	V>M	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1584267392 CA368405987	457	V>A		No	ClinGen Ensembl
CA4352498 rs774000073	457	V>I		No	ClinGen ExAC TOPMed gnomAD
CA368405989 rs1318636318	458	G>S		No	ClinGen gnomAD
TCGA novel	461	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4352500 rs771744628	461	E>G		No	ClinGen ExAC gnomAD
rs1212513692 CA368406021	462	G>D		No	ClinGen TOPMed gnomAD
TCGA novel	462	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1212513692 CA368406023	462	G>V		No	ClinGen TOPMed gnomAD
CA4352501 rs775216924	466	T>A		No	ClinGen ExAC gnomAD
COSM1568791 rs551953723 CA4352502	466	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA368406065 rs1421390269	469	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA163508260 rs372507333	473	K>R		No	ClinGen Ensembl
rs1274131777 CA368406115	474	A>G		No	ClinGen TOPMed
rs1371612729 CA368406134	477	G>A		No	ClinGen gnomAD
rs1371612729 CA368406133	477	G>D		No	ClinGen gnomAD
rs549442524 CA4352521	478	E>G		No	ClinGen 1000Genomes ExAC gnomAD
CA368406153 rs1294756578	480	F>S		No	ClinGen gnomAD
rs761898077 CA4352523	482	G>S		No	ClinGen ExAC gnomAD
rs765259750 CA4352524	489	G>R		No	ClinGen ExAC gnomAD
CA4352525 rs746553009	490	I>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	493	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368406261 rs879159002	496	V>L		No	ClinGen gnomAD
rs879159002 CA163508262	496	V>M		No	ClinGen gnomAD
TCGA novel	497	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752919446 CA4352528	499	I>V		No	ClinGen ExAC TOPMed gnomAD
CA368406309 rs1295323167	503	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1371490427 CA368406323	505	F>C		No	ClinGen TOPMed
rs373873741 CA163508263	508	S>A		No	ClinGen ESP gnomAD
rs1163790811 CA368406350	510	F>L		No	ClinGen gnomAD
CA368406357 rs1327624477	511	D>N		No	ClinGen TOPMed
CA368406368 rs1462884852	512	W>*		No	ClinGen gnomAD
rs1562981587 CA368406373	512	W>*		No	ClinGen Ensembl
CA368406380 rs1384837024	514	V>I		No	ClinGen TOPMed
CA368406404 rs1318472263	517	W>*		No	ClinGen gnomAD
rs17852086 CA163508265	517	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA368406414 rs1388912172	519	T>A		No	ClinGen TOPMed
TCGA novel	520	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1162879929 CA368406422	520	K>T		No	ClinGen TOPMed
CA4352547 CA4352548 rs767571094	522	N>K		No	ClinGen ExAC gnomAD
CA368252764 rs1350571649	529	E>*		No	ClinGen gnomAD
rs1198886518 CA368252784	531	N>K		No	ClinGen TOPMed
TCGA novel	532	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368252813 rs1206307794	535	V>A		No	ClinGen gnomAD
rs1033384038 CA162961985	536	Y>C		No	ClinGen TOPMed
rs1243010339 CA368252827	537	D>E		No	ClinGen TOPMed
CA4352551 rs754243136	538	V>I		No	ClinGen ExAC gnomAD
CA162962000 rs977041050	539	M>L		No	ClinGen Ensembl
rs762146134 CA4352552	539	M>T		No	ClinGen ExAC
rs1258524344 CA368252855	541	S>F		No	ClinGen gnomAD
TCGA novel	543	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4352554 rs539055695	544	H>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs779672282 CA4352556	546	A>E		No	ClinGen ExAC gnomAD
CA368252893 rs1422377802	548	F>L		No	ClinGen gnomAD
CA4352558 rs754698837	552	D>E		No	ClinGen ExAC gnomAD
rs780966201 CA4352559	555	G>A		No	ClinGen ExAC gnomAD
rs747977134 CA4352560	556	R>L		No	ClinGen ExAC gnomAD
CA368252974 rs1335550302	560	W>R		No	ClinGen gnomAD
rs1281798913 CA368252997	563	N>D		No	ClinGen gnomAD
rs1233615076 CA368253008	564	N>S		No	ClinGen TOPMed gnomAD
rs1385103767 CA368253024	565	D>E		No	ClinGen TOPMed
rs1281194431 CA368253014	565	D>H		No	ClinGen gnomAD
rs141384275 CA4352586	569	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA4352587 rs762080244	570	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1437767268 CA368253646	570	T>I		No	ClinGen TOPMed
rs1352149754 CA368253647	571	A>T		No	ClinGen TOPMed
rs769999342 CA4352588	572	S>N		No	ClinGen ExAC TOPMed gnomAD
CA4352590 rs763204109	574	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1392828428 CA368253668	574	A>V		No	ClinGen gnomAD
rs1447944959 CA368253688	577	G>E		No	ClinGen TOPMed
rs774678955 CA4352592	577	G>R		No	ClinGen ExAC gnomAD
CA368253692 rs1373225662	578	A>S		No	ClinGen gnomAD
CA4352593 rs759118062	579	S>F		No	ClinGen ExAC gnomAD
rs1327227537 CA368253707	580	A>V		No	ClinGen gnomAD
CA4352595 rs752245721	581	L>V		No	ClinGen ExAC gnomAD
CA162965730 rs35077523 VAR_048905	582	N>T		No	ClinGen UniProt TOPMed dbSNP
CA4352596 rs374032937	583	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA4352597 rs763626464 COSM1250833	583	R>H	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs753718608 CA4352598	584	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1463517537 CA368253730	585	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs201767152 CA4352600	585	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1429925406 CA368253762	590	G>C		No	ClinGen TOPMed gnomAD
rs967652013 CA162965784	590	G>D		No	ClinGen Ensembl
rs1429925406 CA368253764	590	G>S		No	ClinGen TOPMed gnomAD
TCGA novel	593	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1184971340 CA368253785	593	V>F		No	ClinGen gnomAD
rs781314687 CA4352603	595	V>A		No	ClinGen ExAC TOPMed gnomAD
rs781314687 CA368253798	595	V>G		No	ClinGen ExAC TOPMed gnomAD
CA4352602 rs755064520	595	V>L		No	ClinGen ExAC gnomAD
rs748195049 CA4352604	598	S>L		No	ClinGen ExAC TOPMed gnomAD
rs748195049 CA368253817	598	S>W		No	ClinGen ExAC TOPMed gnomAD
CA368253834 rs1452319389	601	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA4352606 rs768899789	601	R>H		No	ClinGen ExAC TOPMed gnomAD
CA368253835 rs768899789	601	R>L		No	ClinGen ExAC TOPMed gnomAD
rs749691258 CA4352608	603	W>*		No	ClinGen ExAC gnomAD
CA4352609 rs774931974	603	W>C		No	ClinGen ExAC TOPMed gnomAD
rs749691258 CA4352607	603	W>L		No	ClinGen ExAC gnomAD
CA368253862 rs1436474665	605	Y>*		No	ClinGen TOPMed
rs1024293626 CA162965848	606	D>N		No	ClinGen TOPMed
rs145694237 CA4352611	607	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1294951645 CA368253888	608	G>R		No	ClinGen gnomAD
CA368255396 rs1171828336	610	L>P		No	ClinGen gnomAD
CA4352631 rs746207445	611	A>S		No	ClinGen ExAC TOPMed gnomAD
rs746207445 CA368255398	611	A>T		No	ClinGen ExAC TOPMed gnomAD
CA368255400 rs1435500272	611	A>V		No	ClinGen gnomAD
rs772757314 CA4352633	613	P>A		No	ClinGen ExAC TOPMed gnomAD
CA4352632 rs772757314	613	P>S		No	ClinGen ExAC TOPMed gnomAD
CA368255417 rs1461325929	614	H>R		No	ClinGen gnomAD
TCGA novel	615	N>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1298576123 CA368255426	615	N>S		No	ClinGen gnomAD
TCGA novel	617	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1584319961 CA368255458	619	T>S		No	ClinGen Ensembl
rs760294850 CA4352634	620	R>*		No	ClinGen ExAC TOPMed gnomAD
CA4352635 rs767986943	620	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA368255466 rs1563004673	621	F>Y		No	ClinGen Ensembl
rs1371107650 CA368255489	624	T>I		No	ClinGen gnomAD
rs1371107650 CA368255487	624	T>N		No	ClinGen gnomAD
rs761431417 CA4352637	625	L>V		No	ClinGen ExAC gnomAD
CA368255507 rs1270483936	627	E>D		No	ClinGen gnomAD
rs764911432 CA4352638	629	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA368255516 rs1306600806	629	R>S		No	ClinGen gnomAD
CA368255537 rs1584320013	632	R>K		No	ClinGen Ensembl
CA4352639 rs750268008	632	R>S		No	ClinGen ExAC gnomAD
rs556401895 CA162979597	633	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
TCGA novel	637	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368255575 rs1252391059	637	E>V		No	ClinGen gnomAD
TCGA novel	638	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1193095487 CA368255591	639	G>V		No	ClinGen gnomAD
rs756228685 CA4352643	640	T>P		No	ClinGen ExAC gnomAD
CA4352644 rs777769221	642	E>V		No	ClinGen ExAC gnomAD
CA368255618 rs1170868175	644	S>P		No	ClinGen gnomAD

No associated diseases with O14576

1 regional properties for O14576

Type	Name	Position	InterPro Accession
domain	Major facilitator superfamily domain	86 - 513	IPR020846

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle pole
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

11 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic dynein complex	Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.
cytoplasmic ribonucleoprotein granule	A ribonucleoprotein granule located in the cytoplasm.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
kinetochore	A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
recycling endosome	An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
spindle pole	Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
vesicle	Any small, fluid-filled, spherical organelle enclosed by membrane.

6 GO annotations of molecular function

Name	Definition
cytoskeletal motor activity	Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force).
dynein heavy chain binding	Binding to a heavy chain of the dynein complex.
dynein light chain binding	Binding to a light chain of the dynein complex.
microtubule binding	Binding to a microtubule, a filament composed of tubulin monomers.
microtubule motor activity	A motor activity that generates movement along a microtubule, driven by ATP hydrolysis.
spectrin binding	Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers.

3 GO annotations of biological process

Name	Definition
microtubule-based movement	A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
transport along microtubule	The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity.
vesicle transport along microtubule	The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.

5 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9UI46	DNAI1	Dynein axonemal intermediate chain 1	Homo sapiens (Human)	PR
Q8C0M8	Dnai1	Dynein axonemal intermediate chain 1	Mus musculus (Mouse)	PR
O88485	Dync1i1	Cytoplasmic dynein 1 intermediate chain 1	Mus musculus (Mouse)	PR
Q5XIL8	Dnai1	Dynein axonemal intermediate chain 1	Rattus norvegicus (Rat)	PR
Q63100	Dync1i1	Cytoplasmic dynein 1 intermediate chain 1	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MSDKSDLKAE	LERKKQRLAQ	IREEKKRKEE	ERKKKEADMQ	QKKEPVQDDS	DLDRKRRETE
70	80	90	100	110	120
ALLQSIGISP	EPPLVQPLHF	LTWDTCYFHY	LVPTPMSPSS	KSVSTPSEAG	SQDSGDLGPL
130	140	150	160	170	180
TRTLQWDTDP	SVLQLQSDSE	LGRRLHKLGV	SKVTQVDFLP	REVVSYSKET	QTPLATHQSE
190	200	210	220	230	240
EDEEDEEMVE	SKVGQDSELE	NQDKKQEVKE	APPRELTEEE	KQQILHSEEF	LIFFDRTIRV
250	260	270	280	290	300
IERALAEDSD	IFFDYSGREL	EEKDGDVQAG	ANLSFNRQFY	DEHWSKHRVV	TCMDWSLQYP
310	320	330	340	350	360
ELMVASYNNN	EDAPHEPDGV	ALVWNMKFKK	TTPEYVFHCQ	SSVMSVCFAR	FHPNLVVGGT
370	380	390	400	410	420
YSGQIVLWDN	RSHRRTPVQR	TPLSAAAHTH	PVYCVNVVGT	QNAHNLITVS	TDGKMCSWSL
430	440	450	460	470	480
DMLSTPQESM	ELVYNKSKPV	AVTGMAFPTG	DVNNFVVGSE	EGTVYTACRH	GSKAGIGEVF
490	500	510	520	530	540
EGHQGPVTGI	NCHMAVGPID	FSHLFVTSSF	DWTVKLWTTK	HNKPLYSFED	NADYVYDVMW
550	560	570	580	590	600
SPVHPALFAC	VDGMGRLDLW	NLNNDTEVPT	ASVAIEGASA	LNRVRWAQAG	KEVAVGDSEG
610	620	630	640
RIWVYDVGEL	AVPHNDEWTR	FARTLVEIRA	NRADSEEEGT	VELSA