O04716

PR
Gene name
MSH6 (AGAA.3, MSH6-1, At4g02070, T10M13.8)
Protein name
DNA mismatch repair protein MSH6
Names
AtMSH6, MutS protein homolog 6
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G02070
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-359 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O04716

Entry ID Method Resolution Chain Position Source
AF-O04716-F1 Predicted AlphaFoldDB

122 variants for O04716

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH06421014 7 Q>H No 1000Genomes
tmp_4_906158_A_C 27 K>T No 1000Genomes
tmp_4_906173_C_A 32 S>Y No 1000Genomes
tmp_4_906182_C_T 35 P>L No 1000Genomes
tmp_4_906219_A_T 47 K>N No 1000Genomes
tmp_4_906227_A_T 50 K>I No 1000Genomes
tmp_4_906244_C_T 56 P>S No 1000Genomes
ENSVATH06421018 69 T>I No 1000Genomes
ENSVATH10521548 70 P>S No 1000Genomes
tmp_4_906297_C_A 73 N>K No 1000Genomes
tmp_4_906332_C_A 85 P>H No 1000Genomes
ENSVATH02618575 90 D>A No 1000Genomes
ENSVATH10521552 107 G>R No 1000Genomes
tmp_4_906404_C_A 109 T>K No 1000Genomes
ENSVATH06421020 117 V>A No 1000Genomes
tmp_4_906459_G_C 127 K>N No 1000Genomes
tmp_4_906463_G_A 129 V>I No 1000Genomes
tmp_4_906531_G_T 151 E>D No 1000Genomes
ENSVATH06421023 163 E>Q No 1000Genomes
ENSVATH06421024 172 K>N No 1000Genomes
ENSVATH02618576 173 T>I No 1000Genomes
ENSVATH06421025 177 V>I No 1000Genomes
tmp_4_906610_G_A 178 G>R No 1000Genomes
tmp_4_906628_A_G 184 R>G No 1000Genomes
tmp_4_906629_G_T 184 R>M No 1000Genomes
ENSVATH06421026 187 R>L No 1000Genomes
tmp_4_906712_G_C 212 E>Q No 1000Genomes
tmp_4_906892_A_G 272 T>A No 1000Genomes
ENSVATH10521554 283 T>M No 1000Genomes
ENSVATH10521565 285 S>L No 1000Genomes
ENSVATH06421028 285 S>P No 1000Genomes
tmp_4_906959_A_G 294 D>G No 1000Genomes
ENSVATH00453920 298 I>N No 1000Genomes
ENSVATH02618577 315 Q>E No 1000Genomes
ENSVATH02618585 334 A>S No 1000Genomes
ENSVATH02618585 334 A>T No 1000Genomes
tmp_4_907228_C_T 338 A>V No 1000Genomes
ENSVATH00453924 340 D>E No 1000Genomes
ENSVATH06421032 361 D>E No 1000Genomes
ENSVATH00453928 380 T>S No 1000Genomes
ENSVATH00453933 391 A>S No 1000Genomes
ENSVATH02618619 448 R>S No 1000Genomes
ENSVATH10521656 467 Q>L No 1000Genomes
ENSVATH13878750 494 D>N No 1000Genomes
tmp_4_908564_C_A 500 T>N No 1000Genomes
ENSVATH02618623 519 N>D No 1000Genomes
ENSVATH02618624 520 P>H No 1000Genomes
ENSVATH00453943 536 Q>K No 1000Genomes
tmp_4_908686_G_A 541 G>S No 1000Genomes
tmp_4_908788_G_T 544 K>N No 1000Genomes
tmp_4_908808_C_G 551 A>G No 1000Genomes
ENSVATH00453947 569 K>R No 1000Genomes
ENSVATH10521658 600 S>P No 1000Genomes
tmp_4_908967_T_C 604 I>T No 1000Genomes
tmp_4_908971_T_A 605 Y>* No 1000Genomes
ENSVATH00453949 605 Y>H No 1000Genomes
ENSVATH10521659 607 V>I No 1000Genomes
ENSVATH02618631 608 G>E No 1000Genomes
ENSVATH00453950 610 I>F No 1000Genomes
tmp_4_908994_G_A 613 R>Q No 1000Genomes
ENSVATH06421050 614 I>S No 1000Genomes
ENSVATH00453951 615 N>S No 1000Genomes
tmp_4_909062_C_T 636 L>F No 1000Genomes
tmp_4_909125_C_T 657 L>F No 1000Genomes
ENSVATH00453953 660 A>T No 1000Genomes
ENSVATH06421051 672 S>G No 1000Genomes
tmp_4_909186_C_T 677 A>V No 1000Genomes
tmp_4_909198_C_T 681 S>F No 1000Genomes
tmp_4_909210_G_C 685 C>S No 1000Genomes
tmp_4_909240_A_G 695 H>R No 1000Genomes
tmp_4_909254_G_A 700 A>T No 1000Genomes
tmp_4_909302_G_A 716 G>S No 1000Genomes
ENSVATH10521661 742 A>T No 1000Genomes
tmp_4_909457_C_T 742 A>V No 1000Genomes
ENSVATH00453956 753 E>K No 1000Genomes
ENSVATH00453965 775 S>L No 1000Genomes
tmp_4_910139_C_T 822 R>C No 1000Genomes
tmp_4_910182_C_G 836 A>G No 1000Genomes
ENSVATH00453969 842 T>K No 1000Genomes
ENSVATH06421064 859 I>V No 1000Genomes
ENSVATH06421066 862 S>T No 1000Genomes
ENSVATH06421067 862 S>Y No 1000Genomes
tmp_4_910367_G_C 873 V>L No 1000Genomes
tmp_4_910488_G_A 913 R>Q No 1000Genomes
ENSVATH06421069 913 R>W No 1000Genomes
tmp_4_910505_G_T,A 919 A>S No 1000Genomes
tmp_4_910505_G_T,A 919 A>T No 1000Genomes
ENSVATH00453973 938 S>T No 1000Genomes
ENSVATH06421071 941 G>A No 1000Genomes
tmp_4_910932_A_T 975 K>I No 1000Genomes
ENSVATH13878817 980 S>L No 1000Genomes
tmp_4_911021_T_A 1005 S>T No 1000Genomes
tmp_4_911022_C_A 1005 S>Y No 1000Genomes
ENSVATH06421079 1037 S>F No 1000Genomes
tmp_4_911559_C_T 1057 S>L No 1000Genomes
tmp_4_911616_C_T 1076 A>V No 1000Genomes
tmp_4_911700_A_T 1104 Q>L No 1000Genomes
ENSVATH00453984 1116 V>I No 1000Genomes
ENSVATH06421081 1119 V>A No 1000Genomes
tmp_4_911837_G_A 1119 V>I No 1000Genomes
ENSVATH00453985 1121 K>R No 1000Genomes
ENSVATH06421083 1155 R>Q No 1000Genomes
ENSVATH00453988 1156 N>K No 1000Genomes
tmp_4_912118_T_A 1157 S>T No 1000Genomes
ENSVATH00453990 1182 E>Q No 1000Genomes
tmp_4_912294_A_C 1187 K>Q No 1000Genomes
tmp_4_912529_G_A 1222 E>K No 1000Genomes
tmp_4_912539_G_T 1225 G>V No 1000Genomes
tmp_4_912581_G_C 1239 G>A No 1000Genomes
tmp_4_912746_T_C 1264 V>A No 1000Genomes
ENSVATH00453998 1273 L>F No 1000Genomes
tmp_4_912797_C_A 1281 T>N No 1000Genomes
ENSVATH06421090 1284 K>I No 1000Genomes
ENSVATH00453999 1286 A>S No 1000Genomes
ENSVATH02618655 1291 Q>E No 1000Genomes
ENSVATH06421091 1294 S>G No 1000Genomes
tmp_4_912872_A_T 1306 K>M No 1000Genomes
ENSVATH00454000 1310 C>S No 1000Genomes
ENSVATH02618656 1311 E>D No 1000Genomes
ENSVATH00454002 1321 R>Q No 1000Genomes
ENSVATH06421092 1322 L>S No 1000Genomes
ENSVATH10521792 1323 T>S No 1000Genomes

No associated diseases with O04716

6 regional properties for O04716

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 1076 - 1270 IPR000432
domain Tudor domain 121 - 179 IPR002999
domain DNA mismatch repair protein MutS-like, N-terminal 380 - 495 IPR007695
domain DNA mismatch repair protein MutS, core 702 - 1056 IPR007696
domain DNA mismatch repair protein MutS, connector domain 506 - 667 IPR007860
domain DNA mismatch repair protein MutS, clamp 886 - 976 IPR007861

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
MutSalpha complex A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
damaged DNA binding Binding to damaged DNA.
double-stranded DNA binding Binding to double-stranded DNA.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

2 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
pyrimidine dimer repair The repair of UV-induced T-T, C-T and C-C dimers.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P52701 MSH6 DNA mismatch repair protein Msh6 Homo sapiens (Human) PR
Q9SMV7 MSH7 DNA mismatch repair protein MSH7 Arabidopsis thaliana (Mouse-ear cress) PR
F4JP48 MSH4 DNA mismatch repair protein MSH4 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAPSRRQISG RSPLVNQQRQ ITSFFGKSAS SSSSPSPSPS PSLSNKKTPK SNNPNPKSPS
70 80 90 100 110 120
PSPSPPKKTP KLNPNPSSNL PARSPSPGPD TPSPVQSKFK KPLLVIGQTP SPPQSVVITY
130 140 150 160 170 180
GDEVVGKQVR VYWPLDKKWY DGSVTFYDKG EGKHVVEYED GEEESLDLGK EKTEWVVGEK
190 200 210 220 230 240
SGDRFNRLKR GASALRKVVT DSDDDVEMGN VEEDKSDGDD SSDEDWGKNV GKEVCESEED
250 260 270 280 290 300
DVELVDENEM DEEELVEEKD EETSKVNRVS KTDSRKRKTS EVTKSGGEKK SKTDTGTILK
310 320 330 340 350 360
GFKASVVEPA KKIGQADRVV KGLEDNVLDG DALARFGARD SEKFRFLGVD RRDAKRRRPT
370 380 390 400 410 420
DENYDPRTLY LPPDFVKKLT GGQRQWWEFK AKHMDKVVFF KMGKFYELFE MDAHVGAKEL
430 440 450 460 470 480
DIQYMKGEQP HCGFPEKNFS VNIEKLVRKG YRVLVVEQTE TPDQLEQRRK ETGSKDKVVK
490 500 510 520 530 540
REVCAVVTKG TLTDGEMLLT NPDASYLMAL TEGGESLTNP TAEHNFGVCL VDVATQKIIL
550 560 570 580 590 600
GQFKDDQDCS ALSCLLSEMR PVEIIKPAKV LSYATERTIV RQTRNPLVNN LVPLSEFWDS
610 620 630 640 650 660
EKTIYEVGII YKRINCQPSS AYSSEGKILG DGSSFLPKML SELATEDKNG SLALSALGGA
670 680 690 700 710 720
IYYLRQAFLD ESLLRFAKFE SLPYCDFSNV NEKQHMVLDA AALENLEIFE NSRNGGYSGT
730 740 750 760 770 780
LYAQLNQCIT ASGKRLLKTW LARPLYNTEL IKERQDAVAI LRGENLPYSL EFRKSLSRLP
790 800 810 820 830 840
DMERLIARMF SSIEASGRNG DKVVLYEDTA KKQVQEFIST LRGCETMAEA CSSLRAILKH
850 860 870 880 890 900
DTSRRLLHLL TPGQSLPNIS SSIKYFKDAF DWVEAHNSGR VIPHEGADEE YDCACKTVEE
910 920 930 940 950 960
FESSLKKHLK EQRKLLGDAS INYVTVGKDE YLLEVPESLS GSVPHDYELC SSKKGVSRYW
970 980 990 1000 1010 1020
TPTIKKLLKE LSQAKSEKES ALKSISQRLI GRFCEHQEKW RQLVSATAEL DVLISLAFAS
1030 1040 1050 1060 1070 1080
DSYEGVRCRP VISGSTSDGV PHLSATGLGH PVLRGDSLGR GSFVPNNVKI GGAEKASFIL
1090 1100 1110 1120 1130 1140
LTGPNMGGKS TLLRQVCLAV ILAQIGADVP AETFEVSPVD KICVRMGAKD HIMAGQSTFL
1150 1160 1170 1180 1190 1200
TELSETAVML TSATRNSLVV LDELGRGTAT SDGQAIAESV LEHFIEKVQC RGFFSTHYHR
1210 1220 1230 1240 1250 1260
LSVDYQTNPK VSLCHMACQI GEGIGGVEEV TFLYRLTPGA CPKSYGVNVA RLAGLPDYVL
1270 1280 1290 1300 1310 1320
QRAVIKSQEF EALYGKNHRK TDHKLAAMIK QIISSVASDS DYSASKDSLC ELHSMANTFL
RLTN