F4KAK5

PR
Gene name
PSD2 (At5g57190, MUL3.14)
Protein name
Phosphatidylserine decarboxylase proenzyme 2
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G57190
EC number
4.1.1.65: Carboxy-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-70 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for F4KAK5

Entry ID Method Resolution Chain Position Source
AF-F4KAK5-F1 Predicted AlphaFoldDB

48 variants for F4KAK5

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_5_23175303_A_T 21 L>Q No 1000Genomes
ENSVATH12823543 30 H>Y No 1000Genomes
ENSVATH07438707 46 V>I No 1000Genomes
ENSVATH07438706 50 D>E No 1000Genomes
ENSVATH14637214 89 T>I No 1000Genomes
ENSVATH14637215 89 T>S No 1000Genomes
tmp_5_23174895_A_T 94 W>R No 1000Genomes
ENSVATH14637213 100 L>I No 1000Genomes
tmp_5_23174629_G_A 121 A>V No 1000Genomes
tmp_5_23174626_C_G 122 R>T No 1000Genomes
tmp_5_23174605_C_A 129 C>F No 1000Genomes
ENSVATH03443199 140 E>K No 1000Genomes
ENSVATH03443198 186 V>M No 1000Genomes
ENSVATH12823504 197 S>T No 1000Genomes
tmp_5_23174052_G_C 212 A>G No 1000Genomes
tmp_5_23173910_C_T 228 G>D No 1000Genomes
ENSVATH12823502 242 Q>H No 1000Genomes
tmp_5_23173738_A_C 249 I>R No 1000Genomes
tmp_5_23173643_T_C 281 N>D No 1000Genomes
ENSVATH07438687 293 Q>E No 1000Genomes
tmp_5_23173515_C_T 298 W>* No 1000Genomes
tmp_5_23173484_T_G 308 L>F No 1000Genomes
tmp_5_23173460_A_T 316 N>K No 1000Genomes
tmp_5_23173458_G_C 317 T>S No 1000Genomes
tmp_5_23173456_C_A 318 G>C No 1000Genomes
tmp_5_23173306_T_G 332 K>Q No 1000Genomes
tmp_5_23173249_A_G 351 Y>H No 1000Genomes
ENSVATH07438682 393 E>D No 1000Genomes
tmp_5_23172779_A_C 418 F>V No 1000Genomes
ENSVATH14637211 438 A>S No 1000Genomes
ENSVATH07438675 447 M>I No 1000Genomes
ENSVATH07438674 448 A>S No 1000Genomes
tmp_5_23172482_C_T 472 G>E No 1000Genomes
tmp_5_23172461_G_A 479 A>V No 1000Genomes
tmp_5_23172422_G_A 492 P>L No 1000Genomes
ENSVATH07438669 495 Y>F No 1000Genomes
tmp_5_23172294_A_G 506 I>T No 1000Genomes
ENSVATH03443195 510 V>M No 1000Genomes
ENSVATH12823440 511 D>N No 1000Genomes
tmp_5_23172149_T_C 520 N>S No 1000Genomes
ENSVATH07438662 545 A>S No 1000Genomes
ENSVATH07438660 575 K>R No 1000Genomes
ENSVATH12823391 592 V>I No 1000Genomes
ENSVATH03443192 597 A>G No 1000Genomes
ENSVATH00738826 599 G>R No 1000Genomes
ENSVATH00738826 599 G>W No 1000Genomes
tmp_5_23171595_A_G 615 L>S No 1000Genomes
ENSVATH12823390 633 T>S No 1000Genomes

No associated diseases with F4KAK5

4 regional properties for F4KAK5

Type Name Position InterPro Accession
domain C2 domain 20 - 146 IPR000008
domain EF-hand domain 174 - 245 IPR002048
binding_site EF-Hand 1, calcium-binding site 187 - 199 IPR018247-1
binding_site EF-Hand 1, calcium-binding site 223 - 235 IPR018247-2

Functions

Description
EC Number 4.1.1.65 Carboxy-lyases
Subcellular Localization
  • Vacuole membrane ; Peripheral membrane protein
  • Tonoplast
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plant-type vacuole membrane The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana.

2 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
phosphatidylserine decarboxylase activity Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine.

2 GO annotations of biological process

Name Definition
phosphatidylethanolamine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
protein autoprocessing Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5JN42 PSD2 Phosphatidylserine decarboxylase proenzyme 2 Oryza sativa subsp japonica (Rice) PR
A4GNA8 PSD3 Phosphatidylserine decarboxylase proenzyme 3 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGNGNSREAK ESRRSRLRHK LQKFRIHRRH LRSSRNSAGM VIQRTVSAED FSGIALLTLI
70 80 90 100 110 120
GAEMKFKDKW LACVSFGEQT FRTEISDTTQ KPIWNSEKKL LLEKNGPSLA RVSVFETNRV
130 140 150 160 170 180
ARNKIIGYCE LDIFDFVVQE PESTCKSFNL LDPTSSNVVG SIFLSCAIED PVETERRFAK
190 200 210 220 230 240
RILSIVDYNE DGQLSFSEFS DLIKAFGNLV AANKKEELFK AADLNGDGVV TIDELAALLA
250 260 270 280 290 300
LQQEQEPIIN NCPVCGEALQ VSDKLNAMIH MTLCFDEGTG NQVMTGGFLT DRQASYGWMF
310 320 330 340 350 360
KLSEWTHLST YDVGLNTGSS ASYIVVIDRK SKRLVEELID SKIVLSMRAI YQSKIGLRLM
370 380 390 400 410 420
DQGAKEILQR LSEKQGKKMS SVESAQKIPR FLEFFKDQIN MAEVKYPLQH FKTFNEFFIR
430 440 450 460 470 480
ELKPGARPIA CMNRNDVAVC AADCRLMAFQ SVEDSTRFWI KGKKFSIRGL LGKNVNPNAF
490 500 510 520 530 540
LDGSLVIFRL APQDYHRFHV PVSGVIEQFV DVSGSLYTVN PIAVNSKYCN VFTENKRTVA
550 560 570 580 590 600
IISTAEFGKV AFVAIGATMV GSINFVRKEG EHVKKGDELG YFSFGGSTVI CVFEKDAIGI
610 620 630
DNDLLVNSGR SLETLVSVGM QLGVSTRTFA RSTLI