AiPD: Autoinhibited Protein Database

Gene name	PSD3 (At4g25970, F20B18.80)
Protein name	Phosphatidylserine decarboxylase proenzyme 3
Names
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT4G25970
EC number	4.1.1.65: Carboxy-lyases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-62 (Predicted disordered autoinhibitory region) PR

1-62 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-A4GNA8-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH06776387	12	S>L	No	1000Genomes
ENSVATH06776388	28	R>S	No	1000Genomes
ENSVATH12230677	29	R>C	No	1000Genomes
ENSVATH06776389	32	R>G	No	1000Genomes
tmp_4_13184334_G_A	32	R>H	No	1000Genomes
tmp_4_13184351_G_C	38	V>L	No	1000Genomes
tmp_4_13184363_G_A	42	A>T	No	1000Genomes
ENSVATH06776393	90	T>I	No	1000Genomes
tmp_4_13185004_C_T	135	L>F	No	1000Genomes
ENSVATH00538668	138	V>L	No	1000Genomes
ENSVATH00538669	140	Q>L	No	1000Genomes
tmp_4_13185272_C_G	142	P>R	No	1000Genomes
ENSVATH12230680	145	T>S	No	1000Genomes
ENSVATH02924660	162	S>I	No	1000Genomes
tmp_4_13186102_G_A	242	V>I	No	1000Genomes
ENSVATH12230737	248	P>A	No	1000Genomes
tmp_4_13186261_C_T	262	L>F	No	1000Genomes
ENSVATH06776410	323	I>V	No	1000Genomes
tmp_4_13187468_A_T	402	E>V	No	1000Genomes
ENSVATH06776419	450	S>L	No	1000Genomes
ENSVATH02924677	453	D>N	No	1000Genomes
tmp_4_13188418_A_G	537	T>A	No	1000Genomes
tmp_4_13188672_G_C	561	S>T	No	1000Genomes
ENSVATH00538687	594	K>R	No	1000Genomes
ENSVATH06776425	634	E>K	No	1000Genomes
tmp_4_13189137_T_C	636	P>R	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	C2 domain	22 - 147	IPR000008
domain	EF-hand domain	179 - 246	IPR002048
binding_site	EF-Hand 1, calcium-binding site	188 - 200	IPR018247-1
binding_site	EF-Hand 1, calcium-binding site	224 - 236	IPR018247-2

		Description
EC Number	4.1.1.65	Carboxy-lyases
Subcellular Localization	Endoplasmic reticulum membrane ; Lipid-anchor
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.

Name	Definition
calcium ion binding	Binding to a calcium ion (Ca2+).
phosphatidylserine decarboxylase activity	Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine.

Name	Definition
phosphatidylethanolamine biosynthetic process	The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
protein autoprocessing	Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5JN42	PSD2	Phosphatidylserine decarboxylase proenzyme 2	Oryza sativa subsp japonica (Rice)	PR
F4KAK5	PSD2	Phosphatidylserine decarboxylase proenzyme 2	Arabidopsis thaliana (Mouse-ear cress)	PR