F4IME2
PR
Gene name |
MSL8 |
Protein name |
Mechanosensitive ion channel protein 8 |
Names |
Mechanosensitive channel of small conductance-like 8, MscS-Like protein 8 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G17010 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for F4IME2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-F4IME2-F1 | Predicted | AlphaFoldDB |
71 variants for F4IME2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH13225165 | 22 | Q>L | No | 1000Genomes | |
| tmp_2_7395859_G_A | 38 | P>S | No | 1000Genomes | |
| tmp_2_7395815_G_T | 52 | S>R | No | 1000Genomes | |
| ENSVATH05509662 | 55 | S>P | No | 1000Genomes | |
| tmp_2_7395743_G_T | 76 | D>E | No | 1000Genomes | |
| ENSVATH01823485 | 84 | D>N | No | 1000Genomes | |
| ENSVATH00233620 | 86 | T>M | No | 1000Genomes | |
| ENSVATH05509661 | 86 | T>S | No | 1000Genomes | |
| ENSVATH01823484 | 87 | A>E | No | 1000Genomes | |
| ENSVATH01823483 | 89 | R>G | No | 1000Genomes | |
| tmp_2_7395693_T_A | 93 | K>I | No | 1000Genomes | |
| ENSVATH13225144 | 106 | S>C | No | 1000Genomes | |
| tmp_2_7395653_G_C | 106 | S>R | No | 1000Genomes | |
| ENSVATH13225143 | 117 | P>L | No | 1000Genomes | |
| ENSVATH05509660 | 149 | Q>H | No | 1000Genomes | |
| ENSVATH05509659 | 152 | D>N | No | 1000Genomes | |
| ENSVATH14506660 | 160 | P>H | No | 1000Genomes | |
| ENSVATH14506660 | 160 | P>L | No | 1000Genomes | |
| tmp_2_7395477_G_T | 165 | T>K | No | 1000Genomes | |
| tmp_2_7395456_G_A | 172 | A>V | No | 1000Genomes | |
| ENSVATH01823482 | 185 | A>V | No | 1000Genomes | |
| tmp_2_7395393_G_A | 193 | S>L | No | 1000Genomes | |
| ENSVATH05509658 | 197 | S>L | No | 1000Genomes | |
| tmp_2_7395352_C_A,T | 207 | A>S | No | 1000Genomes | |
| tmp_2_7395352_C_A,T | 207 | A>T | No | 1000Genomes | |
| tmp_2_7395346_T_C | 209 | M>V | No | 1000Genomes | |
| ENSVATH13225141 | 211 | T>M | No | 1000Genomes | |
| ENSVATH05509657 | 248 | L>F | No | 1000Genomes | |
| ENSVATH01823477 | 273 | A>G | No | 1000Genomes | |
| ENSVATH05509656 | 289 | D>E | No | 1000Genomes | |
| ENSVATH05509653 | 309 | A>V | No | 1000Genomes | |
| ENSVATH05509652 | 315 | A>G | No | 1000Genomes | |
| tmp_2_7394902_C_T | 357 | V>I | No | 1000Genomes | |
| ENSVATH05509650 | 415 | V>I | No | 1000Genomes | |
| ENSVATH01823475 | 424 | L>V | No | 1000Genomes | |
| ENSVATH00233616 | 428 | L>F | No | 1000Genomes | |
| ENSVATH14506658 | 455 | A>V | No | 1000Genomes | |
| ENSVATH01823472 | 456 | L>F | No | 1000Genomes | |
| tmp_2_7394565_G_T | 469 | P>H | No | 1000Genomes | |
| ENSVATH14506657 | 479 | E>D | No | 1000Genomes | |
| tmp_2_7394526_C_T | 482 | R>Q | No | 1000Genomes | |
| ENSVATH13225139 | 485 | D>E | No | 1000Genomes | |
| ENSVATH13225138 | 488 | F>L | No | 1000Genomes | |
| tmp_2_7394475_G_T | 499 | P>Q | No | 1000Genomes | |
| tmp_2_7394464_C_T | 503 | A>T | No | 1000Genomes | |
| tmp_2_7394449_G_T | 508 | P>T | No | 1000Genomes | |
| ENSVATH05509648 | 515 | M>I | No | 1000Genomes | |
| tmp_2_7394398_T_G | 525 | K>Q | No | 1000Genomes | |
| ENSVATH13225137 | 558 | R>K | No | 1000Genomes | |
| tmp_2_7394262_A_T | 570 | L>Q | No | 1000Genomes | |
| ENSVATH05509646 | 599 | V>I | No | 1000Genomes | |
| ENSVATH14506656 | 602 | R>H | No | 1000Genomes | |
| ENSVATH13225102 | 613 | M>V | No | 1000Genomes | |
| ENSVATH01823468 | 626 | G>A | No | 1000Genomes | |
| tmp_2_7394013_G_A | 627 | L>F | No | 1000Genomes | |
| tmp_2_7393759_C_G | 679 | A>P | No | 1000Genomes | |
| ENSVATH05509642 | 728 | I>V | No | 1000Genomes | |
| tmp_2_7393343_C_T | 791 | E>K | No | 1000Genomes | |
| ENSVATH13225098 | 799 | P>T | No | 1000Genomes | |
| ENSVATH05509636 | 801 | E>D | No | 1000Genomes | |
| ENSVATH00233603 | 804 | S>A | No | 1000Genomes | |
| ENSVATH00233602 | 805 | V>L | No | 1000Genomes | |
| ENSVATH05509635 | 809 | R>G | No | 1000Genomes | |
| tmp_2_7393283_A_T | 811 | S>T | No | 1000Genomes | |
| ENSVATH01823461 | 812 | N>T | No | 1000Genomes | |
| ENSVATH05509631 | 841 | A>V | No | 1000Genomes | |
| ENSVATH05509630 | 890 | M>L | No | 1000Genomes | |
| ENSVATH13225074 | 892 | T>I | No | 1000Genomes | |
| tmp_2_7392963_A_T | 893 | V>D | No | 1000Genomes | |
| tmp_2_7392922_G_C | 907 | P>A | No | 1000Genomes | |
| ENSVATH05509629 | 908 | A>T | No | 1000Genomes |
No associated diseases with F4IME2
No regional properties for F4IME2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for F4IME2 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endomembrane system | A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| mechanosensitive ion channel activity | Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| anion transport | The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDFRNSFKSH | SSYKQIRSPG | DQSEPSPEHL | PILHDHHPDH | SGMVVDDQKP | DSTRSSLDDG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RNAPVERDAS | YKFWQDNTTG | TSTDHTAVRT | SDKDPIAISR | KGDRLSGSFD | FVHGKLPVDE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SPTKMVAGEP | VNRQWRGRNN | EEITLDVDQE | NDDVSHQTMP | TPTSTARTSF | DASREMRVSF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NVRRAGGAFV | AGSVPSSSSH | SSSSSSATMR | TNQDQPQLQE | EEVVRCTSNM | SFQRKSELIS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RVKTRSRLQD | PPREEETPYS | GWRSGQLKSG | LLADIDEEDD | PLAEEDVPDE | YKRGKLDAIT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LLQWLSLVAI | IAALACSLSI | QSWKKVRVWN | LHLWKWEVFL | LVLICGRLVS | GWGIRIVVFF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IERNFLLRKR | VLYFVYGVRR | AVQNCLWLGL | VLLAWHFLFD | KKVQRETRSR | FLPYVTKILV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CFLLSTILWL | IKTLVVKVLA | SSFHVSTYFD | RIQEALFNQY | VIETLSGPPM | IEMSRIEEEE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ERAQDEIFKM | QNAGANLPPD | LCAAAFPPGK | SGRVMNPKLS | PIIPKSTTDN | GISMEHLHRM |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NHKNISAWNM | KRLMKIVRNV | SLTTLDEQML | ESTYEDESTR | QIRSEKEAKA | AARKIFKNVE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QRGAKYIYLE | DLMRFLREDE | AMKTMGLFEG | APENKRISKS | ALKNWLVNAF | RERRALALTL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NDTKTAVNKL | HHMINIVTAI | VIVVIWLVLL | EIASSKVLLF | VSSQVVLLAF | IFGNTVKTVF |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ESIIFLFIVH | PYDVGDRCEI | DSVQLVVEEM | NILTTVFLRY | DNLKIMYPNS | LLWQKSINNY |
| 790 | 800 | 810 | 820 | 830 | 840 |
| YRSPDMGDAI | EFCVHITTPL | EKISVIKQRI | SNYIDNKPEY | WYPQAKIIVK | DLEDLHIVRL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| AIWPCHRINH | QDMAERWTRR | AVLVEEVIKI | LLELDIQHRF | YPLDINVRTM | PTVVSSRVPP |
| GWSQNQPA |