F4IME1

PR
Gene name
MSL7 (At2g17000, F6P23.16)
Protein name
Mechanosensitive ion channel protein 7
Names
Mechanosensitive channel of small conductance-like 7, MscS-Like protein 7
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G17000
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-249 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for F4IME1

Entry ID Method Resolution Chain Position Source
AF-F4IME1-F1 Predicted AlphaFoldDB

104 variants for F4IME1

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_2_7392101_T_C 2 E>G No 1000Genomes
tmp_2_7392096_G_A 4 R>C No 1000Genomes
ENSVATH05509596 4 R>H No 1000Genomes
tmp_2_7392091_T_A 5 K>N No 1000Genomes
ENSVATH01823447 6 P>T No 1000Genomes
ENSVATH13225044 15 Q>* No 1000Genomes
ENSVATH00233597 21 D>N No 1000Genomes
tmp_2_7392040_T_A 22 Q>H No 1000Genomes
ENSVATH01823446 26 T>R No 1000Genomes
tmp_2_7392021_T_C 29 K>E No 1000Genomes
ENSVATH14506609 47 G>R No 1000Genomes
ENSVATH05509594 55 Y>D No 1000Genomes
tmp_2_7391939_T_G 56 K>T No 1000Genomes
ENSVATH05509593 61 I>V No 1000Genomes
tmp_2_7391922_C_T 62 A>T No 1000Genomes
tmp_2_7391913_C_T 65 D>N No 1000Genomes
ENSVATH05509592 67 T>K No 1000Genomes
tmp_2_7391880_G_A 76 Q>* No 1000Genomes
ENSVATH01823445 77 Y>C No 1000Genomes
ENSVATH13225043 92 T>I No 1000Genomes
ENSVATH05509591 96 S>I No 1000Genomes
ENSVATH01823443 97 N>K No 1000Genomes
ENSVATH05509590 105 K>R No 1000Genomes
tmp_2_7391783_C_G,T 108 R>K No 1000Genomes
tmp_2_7391783_C_G,T 108 R>T No 1000Genomes
ENSVATH01823442 110 F>S No 1000Genomes
tmp_2_7391762_C_T 115 S>N No 1000Genomes
tmp_2_7391741_G_T 122 S>Y No 1000Genomes
tmp_2_7391738_C_T 123 G>D No 1000Genomes
ENSVATH01823441 126 R>H No 1000Genomes
ENSVATH05509589 140 R>L No 1000Genomes
ENSVATH05509589 140 R>Q No 1000Genomes
ENSVATH01823440 146 Q>E No 1000Genomes
ENSVATH13225041 152 E>K No 1000Genomes
ENSVATH13225040 157 C>Y No 1000Genomes
ENSVATH05509588 167 S>L No 1000Genomes
ENSVATH05509588 167 S>W No 1000Genomes
tmp_2_7391591_C_T 172 R>K No 1000Genomes
tmp_2_7391577_C_A 177 D>Y No 1000Genomes
tmp_2_7391538_T_G 190 I>L No 1000Genomes
ENSVATH01823439 199 G>S No 1000Genomes
ENSVATH01823438 205 S>F No 1000Genomes
tmp_2_7391482_A_C 208 I>M No 1000Genomes
ENSVATH05509584 208 I>T No 1000Genomes
ENSVATH01823437 209 E>D No 1000Genomes
tmp_2_7391392_C_T 238 M>I No 1000Genomes
tmp_2_7391357_C_T 250 S>N No 1000Genomes
ENSVATH00233592 252 G>A No 1000Genomes
ENSVATH01823436 253 L>F No 1000Genomes
tmp_2_7391346_G_A 254 H>Y No 1000Genomes
ENSVATH05509583 255 T>S No 1000Genomes
ENSVATH05509582 260 T>I No 1000Genomes
ENSVATH05509581 265 H>Y No 1000Genomes
ENSVATH05509579 287 I>N No 1000Genomes
ENSVATH00233586 326 L>V No 1000Genomes
ENSVATH01823433 330 F>I No 1000Genomes
ENSVATH01823431 338 K>R No 1000Genomes
ENSVATH01823427 348 M>I No 1000Genomes
ENSVATH01823428 348 M>V No 1000Genomes
tmp_2_7391027_A_G 360 V>A No 1000Genomes
tmp_2_7390904_G_T 401 P>H No 1000Genomes
ENSVATH14506606 409 I>V No 1000Genomes
ENSVATH05509577 412 E>V No 1000Genomes
ENSVATH05509576 418 D>Y No 1000Genomes
ENSVATH05509575 434 L>R No 1000Genomes
ENSVATH05509574 438 A>S No 1000Genomes
tmp_2_7390772_C_T 445 G>E No 1000Genomes
tmp_2_7390770_T_G 446 S>R No 1000Genomes
ENSVATH01823423 450 M>L No 1000Genomes
ENSVATH05509573 460 G>A No 1000Genomes
ENSVATH01823421 461 S>G No 1000Genomes
ENSVATH14506564 469 D>N No 1000Genomes
tmp_2_7390695_G_A 471 H>Y No 1000Genomes
tmp_2_7390674_C_T 478 V>I No 1000Genomes
ENSVATH13225036 493 V>I No 1000Genomes
ENSVATH00233583 496 S>T No 1000Genomes
tmp_2_7390607_T_A 500 E>V No 1000Genomes
ENSVATH05509572 502 A>E No 1000Genomes
tmp_2_7390382_C_T 547 R>K No 1000Genomes
tmp_2_7390315_C_A 569 K>N No 1000Genomes
ENSVATH01823419 573 S>A No 1000Genomes
ENSVATH01823418 573 S>L No 1000Genomes
ENSVATH13225002 598 T>S No 1000Genomes
ENSVATH13225001 600 V>L No 1000Genomes
ENSVATH01823416 632 L>F No 1000Genomes
ENSVATH01823406 742 R>K No 1000Genomes
tmp_2_7389523_C_T 749 S>N No 1000Genomes
ENSVATH00233575 753 Y>H No 1000Genomes
ENSVATH01823398 760 V>I No 1000Genomes
tmp_2_7389471_T_A 766 E>D No 1000Genomes
ENSVATH13224995 780 K>T No 1000Genomes
tmp_2_7389394_C_A 792 R>I No 1000Genomes
tmp_2_7389391_C_T 793 R>K No 1000Genomes
tmp_2_7389379_A_G 797 I>T No 1000Genomes
ENSVATH13224974 807 L>F No 1000Genomes
tmp_2_7389320_C_A 817 D>Y No 1000Genomes
ENSVATH05509558 834 A>G No 1000Genomes
ENSVATH01823395 837 Q>E No 1000Genomes
ENSVATH05509557 839 P>S No 1000Genomes
ENSVATH01823394 841 L>* No 1000Genomes
ENSVATH01823394 841 L>S No 1000Genomes
ENSVATH09466709 843 R>* No 1000Genomes
tmp_2_7388913_T_C 844 I>V No 1000Genomes
ENSVATH09466708 845 I>N No 1000Genomes

No associated diseases with F4IME1

No regional properties for F4IME1

Type Name Position InterPro Accession
No domain, repeats, and functional sites for F4IME1

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
mechanosensitive ion channel activity Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress.

1 GO annotations of biological process

Name Definition
anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
F4IME2 MSL8 Mechanosensitive ion channel protein 8 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SYM1 MSL6 Mechanosensitive ion channel protein 6 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEFRKPFKSH SSYKQIISTG DQNEKTKKKK KLANLDDGDI AKTQSSGSSF DGNSYKFWQD
70 80 90 100 110 120
IATDDYTKSG SFDFPQYREE ITLDVNEETE ETEDVSNNNN LSGSKETRVF FKINSSGTNN
130 140 150 160 170 180
MSGSVRSCTS STSFSSATMR LNLEQQLEDE GEVVVRCSSV RKTELVSRAK ARSRLIDPPQ
190 200 210 220 230 240
EEEQQYSSWI GTSDQLRSGL LGRHSDDIEE EDDSSAEEDV PVEYRKLKMD AITLLQWMSL
250 260 270 280 290 300
IALVVALVLS LGLHTWRNAT LWSLHLWKWE VVLLVLICGR LVSGCGIRII VFFIERNFLL
310 320 330 340 350 360
RKRVLYFVYG VKTAVQNCLW LGLVLLAWHF LFDKKVEKET QSDVLLLMSK ILVCFLLSTV
370 380 390 400 410 420
LWLIKTLVVK VLASSFHVST YFDRIQEALF HHYLIETLSG PPMLELSRIE EEEDRTQDEI
430 440 450 460 470 480
YKMQKGGADL SPELCSAAFP QEKSGSTMNM KFSPIIPKTG SDNGITMDDL HKMNQKNVSA
490 500 510 520 530 540
WNMKRLMKIV RNVSLSTLDE QALQNTCEDE STRQIRSEKE AKAAARKIFK NVAQPGTKHI
550 560 570 580 590 600
YLEDLMRFLR VDEAMKTMCL FEGALVTKKI TKSALKNWLV NAFRERRALA LTLNDTKTAV
610 620 630 640 650 660
NKLHHMISFL TAIVIIVIWL ILLEIATSKY LLFLTSQVVL LAFMFGNSLK TVFESIIFLF
670 680 690 700 710 720
IIHPYDVGDR LLIDTVEMVV EEMNILTTVF LRADNLKIVY PNILLWQKAI HNYNRSPDMG
730 740 750 760 770 780
DEVTCCVHIT TPPEKIAAIK QRISSYIDSK PEYWYPKADV IVKDVEDLNI VRIAIWLCHK
790 800 810 820 830 840
INHQNMGERF TRRALLIEEV IKILLELDIQ YRFHPLDINV KTMPTVVSSR VPPAWSQNPD
LRRIILLEC