F4I2H7
PR
Gene name |
TPX2 (At1g03780, F11M21.29) |
Protein name |
Protein TPX2 |
Names |
AtTPX2, Targeting protein for XKLP2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G03780 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for F4I2H7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-F4I2H7-F1 | Predicted | AlphaFoldDB |
61 variants for F4I2H7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH04515068 | 2 | E>K | No | 1000Genomes | |
| ENSVATH04515066 | 17 | V>I | No | 1000Genomes | |
| ENSVATH01009931 | 33 | N>D | No | 1000Genomes | |
| ENSVATH13851402 | 59 | V>L | No | 1000Genomes | |
| ENSVATH10540071 | 84 | L>F | No | 1000Genomes | |
| ENSVATH10540070 | 85 | K>Q | No | 1000Genomes | |
| tmp_1_950973_TTTC_GTTC,T | 108 | K>N | No | 1000Genomes | |
| ENSVATH04515060 | 118 | T>S | No | 1000Genomes | |
| tmp_1_950941_A_T | 119 | V>D | No | 1000Genomes | |
| tmp_1_950942_C_T | 119 | V>I | No | 1000Genomes | |
| tmp_1_950935_G_A | 121 | P>L | No | 1000Genomes | |
| tmp_1_950921_A_C | 126 | S>A | No | 1000Genomes | |
| tmp_1_950906_C_T | 131 | V>I | No | 1000Genomes | |
| tmp_1_950891_C_T | 136 | V>I | No | 1000Genomes | |
| ENSVATH00004569 | 141 | P>Q | No | 1000Genomes | |
| ENSVATH00004570 | 141 | P>S | No | 1000Genomes | |
| ENSVATH04515058 | 153 | A>T | No | 1000Genomes | |
| tmp_1_950738_G_A | 158 | P>L | No | 1000Genomes | |
| ENSVATH10540069 | 160 | P>L | No | 1000Genomes | |
| tmp_1_950712_C_G | 167 | G>R | No | 1000Genomes | |
| tmp_1_950708_G_C | 168 | A>G | No | 1000Genomes | |
| tmp_1_950676_C_A | 179 | A>S | No | 1000Genomes | |
| tmp_1_950633_C_T | 193 | R>K | No | 1000Genomes | |
| ENSVATH10540068 | 200 | A>P | No | 1000Genomes | |
| ENSVATH00004567 | 214 | L>V | No | 1000Genomes | |
| tmp_1_950481_T_C | 217 | I>V | No | 1000Genomes | |
| ENSVATH13851399 | 250 | T>I | No | 1000Genomes | |
| tmp_1_950271_C_T | 256 | R>K | No | 1000Genomes | |
| ENSVATH00004565 | 261 | N>S | No | 1000Genomes | |
| ENSVATH13851398 | 265 | N>K | No | 1000Genomes | |
| tmp_1_950226_G_T | 271 | T>N | No | 1000Genomes | |
| ENSVATH01009921 | 278 | N>S | No | 1000Genomes | |
| tmp_1_950125_C_T | 281 | V>I | No | 1000Genomes | |
| tmp_1_949998_G_A | 323 | P>L | No | 1000Genomes | |
| ENSVATH00004564 | 359 | N>D | No | 1000Genomes | |
| tmp_1_949751_G_A | 377 | H>Y | No | 1000Genomes | |
| ENSVATH04515051 | 399 | S>F | No | 1000Genomes | |
| tmp_1_949449_T_C | 411 | N>D | No | 1000Genomes | |
| tmp_1_949368_T_G | 438 | T>P | No | 1000Genomes | |
| tmp_1_949365_T_C | 439 | T>A | No | 1000Genomes | |
| tmp_1_949361_G_A | 440 | A>V | No | 1000Genomes | |
| ENSVATH04515049 | 441 | E>* | No | 1000Genomes | |
| ENSVATH04515048 | 441 | E>V | No | 1000Genomes | |
| ENSVATH10539974 | 478 | H>D | No | 1000Genomes | |
| tmp_1_949118_C_A | 491 | E>D | No | 1000Genomes | |
| tmp_1_948772_C_T | 547 | M>I | No | 1000Genomes | |
| ENSVATH04515042 | 612 | T>I | No | 1000Genomes | |
| tmp_1_948434_T_C | 626 | I>M | No | 1000Genomes | |
| tmp_1_948339_G_A | 630 | P>S | No | 1000Genomes | |
| ENSVATH04515040 | 632 | P>S | No | 1000Genomes | |
| ENSVATH10539970 | 662 | D>N | No | 1000Genomes | |
| ENSVATH10539967 | 707 | N>K | No | 1000Genomes | |
| ENSVATH04515034 | 741 | M>V | No | 1000Genomes | |
| ENSVATH10539966 | 755 | V>L | No | 1000Genomes | |
| ENSVATH04515032 | 765 | F>L | No | 1000Genomes | |
| ENSVATH01009915 | 770 | K>R | No | 1000Genomes | |
| ENSVATH04515031 | 772 | T>P | No | 1000Genomes | |
| tmp_1_947599_T_A | 777 | I>L | No | 1000Genomes | |
| ENSVATH01009914 | 780 | C>F | No | 1000Genomes | |
| tmp_1_947586_A_G | 781 | L>P | No | 1000Genomes | |
| tmp_1_947575_CA_GA,C | 785 | D>H | No | 1000Genomes |
No associated diseases with F4I2H7
Functions
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast envelope | The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
| mitotic spindle | A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. |
| nuclear microtubule | Any microtubule in the nucleus of a cell. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| phragmoplast | Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules. |
| spindle | The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| microtubule binding | Binding to a microtubule, a filament composed of tubulin monomers. |
| protein kinase activator activity | Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| mitotic cell cycle | Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. |
| mitotic spindle assembly | Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied. |
| regulation of mitotic spindle organization | Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. |
| spindle assembly | The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEATAEESVS | TLVTTMVDET | YEFLAPRWFD | FVNGETEDES | RRAELWFQSA | LSCAPSPSVP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RIKARRSFKV | EAMCNFNEAE | EETLKDKEPL | EPVVPIVSLQ | SQPSQAKKAE | VAPSKASTVK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PSRISSKDAE | VNNKTVDASD | PTTEPIEDKE | NIAPACTPKP | PMQFSLGAKS | VDLKKQQTAR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KIASLLKNPS | TLRPKNQSQA | KGSHQKSVKG | ETNLNNIAST | TNLIQENQAI | KRQKLDDGKS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RQILNPKPAT | LLHKTRNGLV | NTGFNLCPSV | TKHTPKENRK | VYVREQIAPF | VSTAELMKKF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QTSTRDLFVQ | NRPKLTLTRP | KEPEFVTSQR | ARPLRVKSSA | ELEEEMLAKI | PKFKARPVNK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KILAAPALPA | PQRSTPHLPE | FQEFHLQTMA | RANQHAETSS | IASTEVSKQH | NDQKHHLTEP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KSPVLQTMLR | ARPTIAKTTA | ELEQEELEKA | PKFKAKPLNK | KIFESKGEMG | IFCNTKKHIT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IPQEFHFATD | ERISRPESVL | DIFDKLSLNS | ESCHEKPLPR | NTAPNPFNLK | TEERGAEKEK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KFYMELMYKK | LGDVKARVPK | ANPYPYTTDY | PVVPPKPEPK | QCTQPEPFQL | ESLVRHEEEM |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RREREERRRM | ETEEAQKRLF | KAQPVIKEDP | IPVPEKVRMP | LTEIQEFNLH | VEHRAVERAD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FDHKIKEKEN | QYKRYREESE | AAKMVEEERA | LKQMRKTMVP | HARPVPNFNK | PFLPQKSNKG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TTKAKSPNLR | VIKRTERRTM | MARPTISAAT | SASAVHCLMY | PGSSFNKLKK | KTVLTNIVHC |
| LMYPDSSLLN |