A2APB8

PR
Gene name
Tpx2
Protein name
Targeting protein for Xklp2
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:72119
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

23-212 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A2APB8

Entry ID Method Resolution Chain Position Source
AF-A2APB8-F1 Predicted AlphaFoldDB

31 variants for A2APB8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs260968744 64 A>T No EVA
rs3392387429 78 D>V No EVA
rs258147472 104 D>N No EVA
rs27349783 112 N>S No EVA
rs3388597047 116 Q>P No EVA
rs3392337359 127 Q>H No EVA
rs3392307739 130 L>F No EVA
rs3392367841 133 K>R No EVA
rs3388592025 225 Q>R No EVA
rs3388597762 277 Q>H No EVA
rs3388599069 317 R>K No EVA
rs3388599131 339 R>* No EVA
rs3388602678 358 K>I No EVA
rs3388601254 360 V>M No EVA
rs3388603470 428 T>I No EVA
rs225716286 450 T>S No EVA
rs50152624 453 E>K No EVA
rs3388601202 476 K>Q No EVA
rs3392307783 479 I>T No EVA
rs27349676 509 V>L No EVA
rs3388603312 525 H>L No EVA
rs3388599088 585 N>I No EVA
rs3410697261 606 M>I No EVA
rs3388603478 621 A>T No EVA
rs3388592116 635 E>G No EVA
rs3388601449 672 E>Q No EVA
rs3410818997 691 V>I No EVA
rs3388593309 717 I>L No EVA
rs3388598753 735 P>S No EVA
rs3388602690 740 F>L No EVA
rs3388597720 746 Q>L No EVA

No associated diseases with A2APB8

5 regional properties for A2APB8

Type Name Position InterPro Accession
domain Aurora-A binding 1 - 68 IPR015128
domain TPX2, C-terminal 542 - 588 IPR027329-1
domain TPX2, C-terminal 659 - 733 IPR027329-2
domain TPX2 central domain 366 - 451 IPR027330-1
domain TPX2 central domain 451 - 489 IPR027330-2

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm, cytoskeleton, spindle
  • Cytoplasm, cytoskeleton, spindle pole
  • During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus
  • Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

11 GO annotations of cellular component

Name Definition
aster An array of microtubules emanating from a spindle pole MTOC that do not connect to kinetochores.
axon hillock Portion of the neuronal cell soma from which the axon originates.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
intercellular bridge A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised.
microtubule cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
mitotic spindle A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
nuclear microtubule Any microtubule in the nucleus of a cell.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spindle The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

4 GO annotations of molecular function

Name Definition
importin-alpha family protein binding Binding to a member of the importin-alpha family.
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.
protein kinase activator activity Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

8 GO annotations of biological process

Name Definition
activation of protein kinase activity Any process that initiates the activity of an inactive protein kinase.
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
microtubule nucleation The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation).
mitotic spindle assembly Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied.
negative regulation of microtubule depolymerization Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.
regulation of mitotic spindle organization Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
spindle assembly The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A6H6Z7 TPX2 Targeting protein for Xklp2 Bos taurus (Bovine) PR
Q9ULW0 TPX2 Targeting protein for Xklp2 Homo sapiens (Human) PR
F4I2H7 TPX2 Protein TPX2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSQVPTTYSF DAPTDFINFS SLDAEEDTEN IDSWFDEKAN LENKFLRQRG IGEPFQGKNS
70 80 90 100 110 120
LRKAKLQQGF VTPLKAVDNT YHKETEKENL QKQSIPSNDC SSLDAKRAVS GNTPVQPQRR
130 140 150 160 170 180
SIRLSAQKDL EQKEKNHVAS VEMKAKRCVA PATDCPPQKR MKVSHKKKLE EEEEGSAPAT
190 200 210 220 230 240
SRKNERETLE KAKGKHTVPG VPPAREKVLK STEEQEIEKR LRMQQEVVEL RRKNEEFKKL
250 260 270 280 290 300
ALAGPGQPVK KSTSQVTKTV DFHFLTDERI KQHPKNQEEY KEVNFMSELR KHSSTPARGT
310 320 330 340 350 360
RGCTIIKPFN LSKGKKRTFD EAASTYVPIA QQVEAFHKRT PNRYHLRNKK DESLLPSKSV
370 380 390 400 410 420
NKIARDPQTP ILQTKYRTRA VTCKSTAEQE AEELEKLQQY KFKARELDPR IFESGPILPK
430 440 450 460 470 480
RAPVKPPTQP VGFDLEIEKR IHERESKKKT EDEQFEFHSR PCPTKILEDV VGVPEKKVIP
490 500 510 520 530 540
ATVPKSPVFA LKNRIRVPIK DEEEEKPVVI KAQPVPHYGV PYKPHIAEAR NVEVCPFSFD
550 560 570 580 590 600
TRDKERQLQK EKKIKEMQKG EVPKFKALPV PHFDTINLPE KKVKNVTQAE PFSLETDKRG
610 620 630 640 650 660
AYKAEMWKHQ LEEEQKQQKD AACFKARPNT VIFQEPFVPK KEKKSLAENP SGSLVQEPFQ
670 680 690 700 710 720
LATERRAKER QELEKKMAEV EAWKLQQLEE VRQQEEEQQK EELARLRKEL VHKANPIRKY
730 740
AAVEVKSSEL PLTVPVSPKF STRFQ