A6H6Z7

PR
Gene name
TPX2
Protein name
Targeting protein for Xklp2
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:507226
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-704 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6H6Z7

Entry ID Method Resolution Chain Position Source
AF-A6H6Z7-F1 Predicted AlphaFoldDB

No variants for A6H6Z7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A6H6Z7

No associated diseases with A6H6Z7

No regional properties for A6H6Z7

Type Name Position InterPro Accession
No domain, repeats, and functional sites for A6H6Z7

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm, cytoskeleton, spindle
  • Cytoplasm, cytoskeleton, spindle pole
  • During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus
  • Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitotic spindle A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
nuclear microtubule Any microtubule in the nucleus of a cell.
spindle The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

3 GO annotations of molecular function

Name Definition
importin-alpha family protein binding Binding to a member of the importin-alpha family.
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.
protein kinase activator activity Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.

4 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
mitotic spindle assembly Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied.
regulation of mitotic spindle organization Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9ULW0 TPX2 Targeting protein for Xklp2 Homo sapiens (Human) PR
A2APB8 Tpx2 Targeting protein for Xklp2 Mus musculus (Mouse) PR
F4I2H7 TPX2 Protein TPX2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSQVTTSYSY DAPTDFINFS SLTDEEDMQH IDSWFDEKAN LENKFTGKDG TGGLYQGKTP
70 80 90 100 110 120
LRKANLHRDV TPLRPVDNTY NKQAEKENLV EESIPSNECP SMKVKETTSR NNPVQPQRRS
130 140 150 160 170 180
LRLSAKKNLE QKEKQHVKMK AKRCGTPVII NEFPPSKKMK VQKILKSTEE QELEKRMKMQ
190 200 210 220 230 240
QEVVEMRKRN EEFKKFALAG AGQPVKKSVS QVTKAVDFHF RTDERVKQHP KNQEEYKEVN
250 260 270 280 290 300
FTSELRKHPP SPARVTKGCT IVMPFNLSQG KKRTFDETAS TYVPLAQQVE AFHKRTPTRY
310 320 330 340 350 360
HLRNRKDDIM PLPSKSVVRI CRDPQTPVLQ TKHRTRPVTC KSAADLEAEE LEKQQQYKFK
370 380 390 400 410 420
AQELDPRILE GGPILPKKPP VKPPTQPVGF DLEIEKRIQE RESKKKLEEE HYEFHSRPCP
430 440 450 460 470 480
TKILEDVVGV PEKKELPITV PKSPAFALKN RIRMPTKEDK EEEEPVMIRA QPVPYFGMPF
490 500 510 520 530 540
KPQIPVGRTV EVCPFSFDSR DKERQLQKEK KIKELQKGEV PKFKAHPLPH FDTINLPEKK
550 560 570 580 590 600
VKNTTQVEPF CLETDRRGAL KAQTWKHQLD EELKQQKEAA CFKARPNTVI SQEPFVPKRE
610 620 630 640 650 660
KKSVIEGLSG SLVQEPFQLA TEKRAKERQE LEKRMAEVEA LKAQQLEEAR QQEEEQQKEE
670 680 690 700
LARLRKELVH KANPIRRYQG VEVKSSDQPL TVPVSPKFST RFHC