A7E320

PR
Gene name
UHRF1
Protein name
E3 ubiquitin-protein ligase UHRF1
Names
RING-type E3 ubiquitin transferase UHRF1, Ubiquitin-like PHD and RING finger domain-containing protein 1, Ubiquitin-like-containing PHD and RING finger domains protein 1
Species
Bos taurus (Bovine)
KEGG Pathway
bta:530411
EC number
2.3.2.27: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

614-714 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7E320

Entry ID Method Resolution Chain Position Source
AF-A7E320-F1 Predicted AlphaFoldDB

300 variants for A7E320

Variant ID(s) Position Change Description Diseaes Association Provenance
rs459681591 16 V>G No EVA
rs441174148 18 S>P No EVA
rs470766788 20 S>P No EVA
rs452708213 22 L>M No EVA
rs437466758 25 V>A No EVA
rs476919624 27 E>Q No EVA
rs455158475 47 Y>S No EVA
rs436573088 48 R>G No EVA
rs465867935 49 G>C No EVA
rs447343771 50 K>R No EVA
rs431964703 51 Q>* No EVA
rs464933522 51 Q>L No EVA
rs464933522 51 Q>R No EVA
rs458036118 52 M>L No EVA
rs439575794 52 M>R No EVA
rs463560909 53 E>D No EVA
rs481994143 53 E>G No EVA
rs475329647 54 D>G No EVA
rs442325446 54 D>Y No EVA
rs459943859 55 G>C No EVA
rs459943859 55 G>R No EVA
rs452193897 56 H>P No EVA
rs470693506 56 H>Y No EVA
rs476233567 57 T>P No EVA
rs436329369 59 F>I No EVA
rs466084406 60 D>G No EVA
rs447398566 61 Y>* No EVA
rs464512251 62 D>A No EVA
rs432120023 62 D>H No EVA
rs446130680 63 V>D No EVA
rs482106545 64 R>P No EVA
rs448463422 66 N>D No EVA
rs481779028 73 V>A No EVA
rs460009731 77 L>R No EVA
rs459117873 81 V>A No EVA
rs443381772 85 S>N No EVA
rs476296854 91 K>N No EVA
rs435943874 94 D>A No EVA
rs472494543 95 S>P No EVA
rs453968498 96 E>A No EVA
rs432226882 100 T>P No EVA
rs432226882 100 T>S No EVA
rs449782027 101 D>A No EVA
rs465029487 101 D>Y No EVA
rs470062690 102 S>F No EVA
rs437304838 102 S>P No EVA
rs481428552 104 C>G No EVA
rs481428552 104 C>R No EVA
rs460021316 109 S>R No EVA
rs447992211 110 E>D No EVA
rs477681821 113 K>N No EVA
rs444638453 115 S>P No EVA
rs444638453 115 S>T No EVA
rs474432732 116 N>Y No EVA
rs482720776 117 S>G No EVA
rs461012777 119 E>* No EVA
rs442411675 119 E>G No EVA
rs461012777 119 E>Q No EVA
rs472255500 120 A>S No EVA
rs453623108 122 N>H No EVA
rs438700359 122 N>T No EVA
rs133210326 126 G>E No EVA
rs471504918 131 D>G No EVA
rs456176986 135 E>* No EVA
rs437715768 138 L>R No EVA
rs454990724 141 Y>C No EVA
rs470286698 141 Y>H No EVA
rs454990724 141 Y>S No EVA
rs436464271 142 K>M No EVA
rs436464271 142 K>T No EVA
rs449475148 146 Y>D No EVA
rs449475148 146 Y>H No EVA
rs798400497 175 P>S No EVA
rs435335634 194 D>V No EVA
rs439875836 200 V>G No EVA
rs476105236 203 M>L No EVA
rs463971377 208 V>A No EVA
rs442200282 210 A>D No EVA
rs474745566 212 A>T No EVA
rs453005028 250 K>R No EVA
rs470597782 261 A>D No EVA
rs437097969 262 N>I No EVA
rs470094000 263 V>G No EVA
rs468144674 274 R>L No EVA
rs434628185 278 V>G No EVA
rs446781660 278 V>L No EVA
rs478390993 279 D>A No EVA
rs445820427 279 D>Y No EVA
rs450826342 282 F>L No EVA
rs461943182 285 E>G No EVA
rs440674217 286 R>L No EVA
rs458319435 287 P>T No EVA
rs475540516 288 G>D No EVA
rs456999224 289 E>G No EVA
rs435245892 292 P>A No EVA
rs474610975 294 V>G No EVA
rs434720909 296 N>K No EVA
rs452884024 296 N>T No EVA
rs436968361 298 M>R No EVA
rs445829867 298 M>V No EVA
rs469937683 299 R>K No EVA
rs442234867 304 P>T No EVA
rs481147488 311 D>E No EVA
rs459419166 313 E>D No EVA
rs440916553 314 R>L No EVA
rs451968701 315 K>N No EVA
rs476511188 317 C>G No EVA
rs476511188 317 C>R No EVA
rs454615268 317 C>S No EVA
rs436133230 318 R>S No EVA
rs468534680 321 A>G No EVA
rs464570286 325 C>* No EVA
rs434840770 325 C>G No EVA
rs434840770 325 C>S No EVA
rs464570286 325 C>W No EVA
rs437536654 330 D>E No EVA
rs470459111 331 P>R No EVA
rs448728779 332 D>E No EVA
rs459903766 333 K>N No EVA
rs481639298 333 K>R No EVA
rs447393644 334 Q>* No EVA
rs477095617 337 C>* No EVA
rs458596643 340 C>R No EVA
rs458596643 340 C>S No EVA
rs443188069 341 D>A No EVA
rs476574405 342 M>R No EVA
rs461056277 345 H>P No EVA
rs442647612 346 I>L No EVA
rs434926200 348 C>* No EVA
rs453734689 348 C>F No EVA
rs472218121 348 C>G No EVA
rs452517158 349 L>P No EVA
rs437158755 350 R>L No EVA
rs437158755 350 R>P No EVA
rs436645813 352 P>R No EVA
rs447883409 353 L>F No EVA
rs477179022 353 L>H No EVA
rs477179022 353 L>P No EVA
rs477179022 353 L>R No EVA
rs447883409 353 L>V No EVA
rs449690631 354 S>R No EVA
rs458559936 354 S>T No EVA
rs482707225 355 S>I No EVA
rs460746376 356 V>L No EVA
rs472301775 361 E>A No EVA
rs460220149 361 E>D No EVA
rs472301775 361 E>G No EVA
rs438573620 362 W>G No EVA
rs438573620 362 W>R No EVA
rs462225430 363 Y>N No EVA
rs440572163 370 D>G No EVA
rs473106155 374 V>G No EVA
rs475450264 381 L>V No EVA
rs456879674 384 S>R No EVA
rs476780127 397 S>P No EVA
rs478307300 412 K>M No EVA
rs469258428 414 C>R No EVA
rs450791384 419 S>T No EVA
rs480753445 424 P>H No EVA
rs462258455 428 I>S No EVA
rs440662638 429 P>R No EVA
rs470427430 445 V>G No EVA
rs448692205 447 R>G No EVA
rs465805390 451 A>G No EVA
rs477056825 453 I>V No EVA
rs443486824 462 Y>S No EVA
rs482722050 463 S>A No EVA
rs461021396 464 L>V No EVA
rs475161728 467 A>G No EVA
rs442561466 467 A>T No EVA
rs441257812 470 Y>* No EVA
rs453354303 470 Y>D No EVA
rs453354303 470 Y>H No EVA
rs470976718 472 D>V No EVA
rs452525431 473 D>H No EVA
rs470464327 474 V>E No EVA
rs473065788 510 R>S No EVA
rs451353208 511 A>P No EVA
rs435438090 515 N>K No EVA
rs434107626 516 C>* No EVA
rs453023295 516 C>F No EVA
rs474828539 516 C>S No EVA
rs445274274 517 F>L No EVA
rs467011024 517 F>S No EVA
rs469172313 521 N>K No EVA
rs451104898 522 D>A No EVA
rs480971557 523 L>I No EVA
rs462388202 523 L>R No EVA
rs446984838 524 K>Q No EVA
rs479584748 524 K>R No EVA
rs439290316 525 G>W No EVA
rs463302244 527 E>A No EVA
rs474894499 528 A>D No EVA
rs441948876 528 A>P No EVA
rs441948876 528 A>S No EVA
rs434601420 529 K>R No EVA
rs470775784 530 D>G No EVA
rs470775784 530 D>V No EVA
rs451702093 531 W>R No EVA
rs43501017 532 R>G No EVA
rs43501017 532 R>W No EVA
rs133583343 533 S>A No EVA
rs133583343 533 S>P No EVA
rs133583343 533 S>T No EVA
rs132805643 533 S>W No EVA
rs468827420 534 G>E No EVA
rs447106030 536 P>S No EVA
rs480084567 546 R>C No EVA
rs458287427 546 R>H No EVA
rs445765666 548 H>Q No EVA
rs481912611 551 Y>N No EVA
rs463384263 554 I>F No EVA
rs441571395 554 I>M No EVA
rs474593939 555 E>G No EVA
rs459605434 557 N>H No EVA
rs441052891 557 N>S No EVA
rs470611228 558 R>G No EVA
rs439700269 559 Y>* No EVA
rs452191275 559 Y>S No EVA
rs475691127 560 D>A No EVA
rs457361447 560 D>E No EVA
rs468561074 562 I>S No EVA
rs464807091 563 Y>* No EVA
rs435028508 563 Y>F No EVA
rs477133508 566 V>G No EVA
rs458696078 567 R>G No EVA
rs443450058 568 Y>* No EVA
rs517522837 569 W>* No EVA
rs482632476 574 K>T No EVA
rs442139338 579 V>G No EVA
rs471950557 582 F>L No EVA
rs475123093 582 F>V No EVA
rs461786726 623 E>G No EVA
rs457659063 685 K>R No EVA
rs457066193 693 L>M No EVA
rs449339932 701 L>H No EVA
rs467820906 701 L>V No EVA
rs437884891 711 V>G No EVA
rs467626054 713 E>V No EVA
rs449078121 715 F>L No EVA
rs478776277 717 C>G No EVA
rs466281670 719 C>G No EVA
rs447740986 723 L>M No EVA
rs477441394 724 V>M No EVA
rs458875471 725 F>L No EVA
rs443954731 730 T>S No EVA
rs479223033 744 S>A No EVA
rs460213039 744 S>Y No EVA
rs462533164 745 F>L No EVA
rs477904939 745 F>S No EVA
rs438438769 745 F>V No EVA
rs444374041 746 K>R No EVA
rs455591091 747 A>D No EVA
rs474113519 747 A>P No EVA
rs440239210 748 Q>K No EVA
rs473181347 748 Q>R No EVA
rs454192090 749 V>A No EVA
rs454192090 749 V>G No EVA
rs465359858 750 F>C No EVA
rs456356603 751 S>T No EVA
rs449454822 752 C>* No EVA
rs437932466 752 C>G No EVA
rs467923902 752 C>S No EVA
rs479255938 753 P>R No EVA
rs467186940 754 A>P No EVA
rs467186940 754 A>T No EVA
rs477921599 755 C>F No EVA
rs477921599 755 C>S No EVA
rs462619193 755 C>W No EVA
rs444059564 756 R>H No EVA
rs444059564 756 R>L No EVA
rs444059564 756 R>P No EVA
rs462040924 757 Y>* No EVA
rs480168564 757 Y>S No EVA
rs440283801 758 D>A No EVA
rs440283801 758 D>G No EVA
rs440283801 758 D>V No EVA
rs451467108 759 L>P No EVA
rs451467108 759 L>R No EVA
rs438915465 760 G>A No EVA
rs471940129 761 R>G No EVA
rs456443419 762 S>I No EVA
rs437967324 762 S>R No EVA
rs473957010 763 Y>H No EVA
rs455923815 763 Y>S No EVA
rs434266920 764 A>P No EVA
rs467164982 764 A>V No EVA
rs469077461 765 M>I No EVA
rs433339008 765 M>R No EVA
rs450569381 766 T>P No EVA
rs446742180 767 V>G No EVA
rs461729968 767 V>L No EVA
rs132705585 768 N>I No EVA
rs132705585 768 N>T No EVA
rs439400646 769 Q>K No EVA
rs462893799 773 A>P No EVA
rs444497957 777 Q>L No EVA
rs474046917 778 L>R No EVA
rs455551189 783 G>V No EVA
rs433942604 786 R>P No EVA

No associated diseases with A7E320

9 regional properties for A7E320

Type Name Position InterPro Accession
domain Ubiquitin-like domain 1 - 75 IPR000626
domain Zinc finger, RING-type 322 - 367 IPR001841-1
domain Zinc finger, RING-type 717 - 756 IPR001841-2
domain Zinc finger, PHD-type 321 - 368 IPR001965
domain SRA-YDG 418 - 590 IPR003105
conserved_site Zinc finger, RING-type, conserved site 732 - 741 IPR017907
domain Zinc finger, PHD-finger 319 - 370 IPR019787
domain UHRF1, tandem tudor domain 139 - 288 IPR021991
domain E3 ubiquitin-protein ligase UHRF1, ubiquitin-like domain 1 - 74 IPR047406

Functions

Description
EC Number 2.3.2.27 Aminoacyltransferases
Subcellular Localization
  • Nucleus
  • Associated, through the YDG domain (also called SRA domain), with replicating DNA from early to late S phase, including at replicating pericentric heterochromatin (By similarity)
  • Also localizes to euchromatic regions
  • In non-S-phase cells, homogenously distributed through the nucleus (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
euchromatin A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation.
heterochromatin A compact and highly condensed form of chromatin that is refractory to transcription.
nuclear matrix The dense fibrillar network lying on the inner side of the nuclear membrane.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
replication fork The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

9 GO annotations of molecular function

Name Definition
cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. The proximal promoter is in cis with and relatively close to the core promoter.
hemi-methylated DNA-binding Binding to double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
identical protein binding Binding to an identical protein or proteins.
methyl-CpG binding Binding to a methylated cytosine/guanine dinucleotide.
methylated histone binding Binding to a histone in which a residue has been modified by methylation.
ubiquitin protein ligase activity Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
ubiquitin-protein transferase activity Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
zinc ion binding Binding to a zinc ion (Zn).

12 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
histone monoubiquitination The modification of histones by addition of a single ubiquitin group.
histone ubiquitination The modification of histones by addition of ubiquitin groups.
maintenance of DNA methylation Any process involved in maintaining the methylation state of a nucleotide sequence.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of protein metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.
protein autoubiquitination The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.
regulation of epithelial cell proliferation Any process that modulates the frequency, rate or extent of epithelial cell proliferation.
ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8VDF2 Uhrf1 E3 ubiquitin-protein ligase UHRF1 Mus musculus (Mouse) PR
Q7TPK1 Uhrf1 E3 ubiquitin-protein ligase UHRF1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MWIQVRTMDG KVAHTVDSLS RLTKVEELRK KIQELFHVEP GLQRLFYRGK QMEDGHTLFD
70 80 90 100 110 120
YDVRLNDTIQ LLVRQSLVLP VPVPSSSGGS KERDSELSDT DSGCGLAQSE SDKSSNSGEA
130 140 150 160 170 180
ANEPEGKADE DECDETELGL YKVGEYVDAR DTNMGAWFEA KVIRVTRKAP AHDQPSSSSS
190 200 210 220 230 240
KPEDDIIYHV TYDDYPENGV VQMTSQNVRA RARHTIKWED LQVGQVVMVN YNPDLPKDRG
250 260 270 280 290 300
FWYDAEILRK RETRTARELH ANVRIGGDSL NDCRIVFVDE VFKIERPGEG NPMVENPMRR
310 320 330 340 350 360
KSGPSCKHCK DDERKLCRMC ACHVCGGKQD PDKQLMCDEC DMAFHIYCLR PPLSSVPPEE
370 380 390 400 410 420
EWYCPDCRID SSEVVQAGEK LKESKKKAKM ASATSSSQRD WGKGMACVGR TKECTIVPSN
430 440 450 460 470 480
HFGPIPGIPV GTMWRFRVQV SESGVHRPHV AGIHGRSNHG AYSLVLAGGY EDDVDHGNSF
490 500 510 520 530 540
TYTGSGGRDL SGNKRTAEQS CDQKLTNTNR ALALNCFAPI NDLKGAEAKD WRSGKPVRVV
550 560 570 580 590 600
RNVKGRKHSK YAPIEGNRYD GIYKVVRYWP EKGKSGFLVW RFLLRRDDVE PGPWTKEGKD
610 620 630 640 650 660
RIKKLGLTMQ YPEGYLEALA RKEKENSKQA ALDKEEEDGE EGFTSPRKGK RKSKSAGGDG
670 680 690 700 710 720
SSRGTPKKTK VEPYSLTTQQ SSLIKEDKSN MKLWTEILKS LKDGPKFLSK VEETFQCICC
730 740 750 760 770 780
QELVFRPITT VCQHNVCKDC LDRSFKAQVF SCPACRYDLG RSYAMTVNQP LQAVLSQLFP
GYGSGR