A1L3C1
Gene name |
Garin5a (Fam71e1, Garil5) |
Protein name |
Golgi-associated RAB2 interactor protein 5A |
Names |
Golgi-associated RAB2B interactor-like 5, GARIL5 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:75538 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A1L3C1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A1L3C1-F1 | Predicted | AlphaFoldDB |
14 variants for A1L3C1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs251638432 | 11 | R>P | No | EVA | |
| rs3388885462 | 38 | E>V | No | EVA | |
| rs3388906805 | 42 | L>Q | No | EVA | |
| rs3388904506 | 48 | F>L | No | EVA | |
| rs3388904523 | 49 | E>Q | No | EVA | |
| rs3398008002 | 60 | E>D | No | EVA | |
| rs3397077422 | 61 | V>F | No | EVA | |
| rs3397868740 | 62 | A>S | No | EVA | |
| rs51007375 | 80 | D>N | No | EVA | |
| rs3388906887 | 90 | E>G | No | EVA | |
| rs31690139 | 138 | R>L | No | EVA | |
| rs3388902194 | 149 | L>I | No | EVA | |
| rs3388902226 | 154 | F>I | No | EVA | |
| rs3388885447 | 205 | Q>K | No | EVA |
No associated diseases with A1L3C1
1 regional properties for A1L3C1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Golgi associated RAB2 interactor protein-like, Rab2B-binding domain | 98 - 158 | IPR022168 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| defense response to virus | Reactions triggered in response to the presence of a virus that act to protect the cell or organism. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| positive regulation of type I interferon production | Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q32L49 | GARIN5A | Golgi-associated RAB2 interactor protein 5A | Bos taurus (Bovine) | PR |
| Q6NXP2 | GARIN1A | Golgi-associated RAB2 interactor protein 1A | Homo sapiens (Human) | PR |
| Q5RJN7 | Garin1a | Golgi-associated RAB2 interactor protein 1A | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKGGRDLKAA | RGGADRPLAP | AYAPCRPGRL | QRHLLSGEFD | QLRDFPIFES | NFVQVTRFGE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VANKVTMGVA | ASSPALELPD | LLLLAGPDKE | NGHLQLLGLF | PLQFVQLFVH | DESRQQLKVK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FRTGRAFYLQ | LRSPPETRDC | EFGRWVRLLY | RLRFHSPTCA | VPFTHEDTAP | EEEEEEEEEE |
| 190 | 200 | 210 | |||
| EEEEVKEGQL | QPPEFQATEA | RLDPQVSELW | GL |