Q9ZVJ3

PR
Gene name
MAP65-5 (At2g38720, T6A23.8)
Protein name
65-kDa microtubule-associated protein 5
Names
AtMAP65-5
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G38720
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

65-139 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9ZVJ3

Entry ID Method Resolution Chain Position Source
AF-Q9ZVJ3-F1 Predicted AlphaFoldDB

52 variants for Q9ZVJ3

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH14596606 5 S>L No 1000Genomes
tmp_2_16188069_C_G 8 T>S No 1000Genomes
ENSVATH00264954 18 M>I No 1000Genomes
ENSVATH14596610 21 D>N No 1000Genomes
tmp_2_16188656_C_T 57 A>V No 1000Genomes
ENSVATH14596611 61 R>Q No 1000Genomes
ENSVATH05679672 66 A>T No 1000Genomes
ENSVATH05679673 71 A>V No 1000Genomes
tmp_2_16188703_C_G 73 L>V No 1000Genomes
ENSVATH05679674 80 K>N No 1000Genomes
tmp_2_16188725_A_C 80 K>T No 1000Genomes
ENSVATH00264955 84 A>P No 1000Genomes
tmp_2_16188868_C_T 99 P>S No 1000Genomes
ENSVATH00264956 102 E>K No 1000Genomes
tmp_2_16188922_G_A 117 E>K No 1000Genomes
tmp_2_16188950_C_A 126 T>K No 1000Genomes
ENSVATH14596612 138 S>F No 1000Genomes
ENSVATH00264957 146 D>H No 1000Genomes
tmp_2_16189204_C_A 183 L>M No 1000Genomes
ENSVATH05679679 203 T>A No 1000Genomes
ENSVATH13575935 214 S>T No 1000Genomes
tmp_2_16189306_A_T 217 T>S No 1000Genomes
ENSVATH01965611 219 A>S No 1000Genomes
ENSVATH05679680 223 E>Q No 1000Genomes
ENSVATH05679682 230 A>E No 1000Genomes
ENSVATH05679684 263 F>L No 1000Genomes
ENSVATH05679685 266 C>F No 1000Genomes
tmp_2_16189705_C_T 271 S>F No 1000Genomes
tmp_2_16189708_G_A 272 S>N No 1000Genomes
tmp_2_16189723_C_T 277 A>V No 1000Genomes
tmp_2_16189749_G_A 286 D>N No 1000Genomes
ENSVATH13575939 302 K>R No 1000Genomes
tmp_2_16189928_T_A 311 F>Y No 1000Genomes
ENSVATH05679687 334 R>I No 1000Genomes
ENSVATH13575940 335 K>R No 1000Genomes
ENSVATH13575940 335 K>T No 1000Genomes
tmp_2_16190003_G_A 336 S>N No 1000Genomes
ENSVATH05679699 354 S>T No 1000Genomes
tmp_2_16190607_A_C 365 E>D No 1000Genomes
tmp_2_16190609_C_T 366 A>V No 1000Genomes
tmp_2_16190641_G_A 377 D>N No 1000Genomes
ENSVATH05679703 407 K>R No 1000Genomes
ENSVATH01965614 410 K>Q No 1000Genomes
ENSVATH05679711 427 D>G No 1000Genomes
tmp_2_16191584_C_T 435 A>V No 1000Genomes
ENSVATH05679713 442 V>I No 1000Genomes
ENSVATH05679715 444 F>C No 1000Genomes
tmp_2_16191881_C_G 478 L>V No 1000Genomes
ENSVATH05679724 494 S>P No 1000Genomes
ENSVATH14596623 495 A>T No 1000Genomes
tmp_2_16192016_G_C 523 G>R No 1000Genomes
ENSVATH00264967 531 K>N No 1000Genomes

No associated diseases with Q9ZVJ3

1 regional properties for Q9ZVJ3

Type Name Position InterPro Accession
domain Armadillo repeat-containing domain 1103 - 1304 IPR006911

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Cytoplasm, cytoskeleton, spindle
  • Cytoplasm, cytoskeleton, phragmoplast
  • Cytoplasm, cell cortex
  • Cell junction, plasmodesma
  • Present in MT cortical arrays
  • Binds the preprophase band and the prophase spindle microtubule during prophase
  • Binds MT during anaphase
  • Associates also with phragmoplast; binds MT of young emerging phragmoplasts but don't binds along MT when the disk-shaped phragmoplasts transform into a ring-shaped, centrifugally expanding structure
  • At this time, accumulates in the cell plate and associates with the surface of the separated nuclei
  • Later traverses the newly formed cross wall, probably in association with plasmodesma
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
phragmoplast Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules.
plasmodesma A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
spindle The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

1 GO annotations of molecular function

Name Definition
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.

3 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P50275 ASE1 Anaphase spindle elongation protein Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
O43663 PRC1 Protein regulator of cytokinesis 1 Homo sapiens (Human) PR
Q9FLP0 MAP65-1 65-kDa microtubule-associated protein 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSPSSTTTCT SLLEELQMIW DEIGESYNER DKMLLELEQE CLDIYNKKVE KTRKFRAELQ
70 80 90 100 110 120
RSLAQAEAEI ASLMSALGEK VSFAKKEGSL KEQISSVKPV LEDLLMKKDR RRKELSETLN
130 140 150 160 170 180
QIAEITSNIA GNDYTVSSGS EVDESDLTQR KLDELRADLQ DLRNEKAVRL QKVNSYISAV
190 200 210 220 230 240
HELSEILSFD FSKALNSVHS SLTEFSKTHS KSISNDTLAR FTELVKSLKA EKHERLLKLQ
250 260 270 280 290 300
GLGRSMQELW NLMETPMDER RRFDHCSSLL SSLPDDALKK GCLSLDIIRE AEDEVRRLNS
310 320 330 340 350 360
LKSSKMKELV FKRQCELEEI CRGNHMDINS DAARKSLVEL IESGDGDLSD ILASIDGQIE
370 380 390 400 410 420
KAREEALSRK EILDKVDKWR HAKEEETWLD DYEKDENRFS AVRGAHKNLK RAEKARSLIS
430 440 450 460 470 480
KIPAMVDVLT TKVKAWEKER GVPFLCDKQP LLQTLEDDIV IRAQREEEKR QFREQKRLQG
490 500 510 520 530 540
QLATEKEAKY GSKSAKKKPL GQSLNTDNVT KTPIGRRIGN TPGRSVTSGG KDYRGNAVIP
LNYVALQKDD