Q9FLP0

PR
Gene name
MAP65-1 (At5g55230, MCO15.18)
Protein name
65-kDa microtubule-associated protein 1
Names
AtMAP65-1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G55230
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

451-587 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9FLP0

Entry ID Method Resolution Chain Position Source
AF-Q9FLP0-F1 Predicted AlphaFoldDB

34 variants for Q9FLP0

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH14633543 22 K>N No 1000Genomes
tmp_5_22402902_A_G 36 E>G No 1000Genomes
tmp_5_22402946_G_C 51 V>L No 1000Genomes
tmp_5_22402952_A_C 53 K>Q No 1000Genomes
tmp_5_22403031_G_A 79 S>N No 1000Genomes
ENSVATH07424623 105 A>G No 1000Genomes
ENSVATH12780971 113 Q>H No 1000Genomes
tmp_5_22403244_A_T 119 E>V No 1000Genomes
tmp_5_22403251_A_T 121 R>S No 1000Genomes
tmp_5_22403252_G_C 122 V>L No 1000Genomes
tmp_5_22403258_G_C 124 E>Q No 1000Genomes
tmp_5_22403264_T_A 126 S>T No 1000Genomes
ENSVATH12780972 134 K>R No 1000Genomes
ENSVATH00735436 138 D>E No 1000Genomes
ENSVATH14633544 170 L>F No 1000Genomes
ENSVATH03433676 172 K>E No 1000Genomes
tmp_5_22403490_A_T 176 D>V No 1000Genomes
tmp_5_22403499_G_A,T 179 R>H No 1000Genomes
tmp_5_22403499_G_A,T 179 R>L No 1000Genomes
ENSVATH03433678 186 S>G No 1000Genomes
tmp_5_22403523_C_T 187 T>I No 1000Genomes
tmp_5_22403631_A_G 223 N>S No 1000Genomes
tmp_5_22403651_G_A 230 A>T No 1000Genomes
ENSVATH07424629 269 E>Q No 1000Genomes
tmp_5_22404039_G_A 300 E>K No 1000Genomes
tmp_5_22404250_C_G 370 A>G No 1000Genomes
ENSVATH07424634 441 T>N No 1000Genomes
ENSVATH07424635 442 R>Q No 1000Genomes
tmp_5_22404735_G_A 467 G>S No 1000Genomes
ENSVATH07424639 499 S>N No 1000Genomes
tmp_5_22404925_A_G 503 S>G No 1000Genomes
tmp_5_22404932_C_T 505 A>V No 1000Genomes
ENSVATH00735440 560 T>I No 1000Genomes
tmp_5_22405148_G_A 577 G>D No 1000Genomes

No associated diseases with Q9FLP0

No regional properties for Q9FLP0

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9FLP0

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Cytoplasm, cytoskeleton, spindle
  • Cytoplasm, cytoskeleton, phragmoplast
  • Cytoplasm, cell cortex
  • During interphase, binds cortical microtubules
  • In M-phase, locates to the preprophase band
  • Binds the preprophase band but does not accumulate at the prophase spindle microtubules that coexists within the same cell
  • In the metaphase and anaphase, localized to spindle
  • In the phragmoplast, concentrated at the midzone where vesicles guide by MT coalesce to form the cell plate
  • Present in MT cortical arrays
  • Concentrated in dots surrounding the nuclei
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
phragmoplast Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules.
spindle The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

2 GO annotations of molecular function

Name Definition
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

3 GO annotations of biological process

Name Definition
cortical microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell.
cytokinesis by cell plate formation The process of dividing the cytoplasm of a parent cell where a structure forms in the cytoplasm and grows until reaching the plasma membrane, thereby completely separating the cytoplasms of adjacent progeny cells. An example of this is found in Arabidopsis thaliana.
microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P50275 ASE1 Anaphase spindle elongation protein Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
O43663 PRC1 Protein regulator of cytokinesis 1 Homo sapiens (Human) PR
Q9ZVJ3 MAP65-5 65-kDa microtubule-associated protein 5 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAVTDTESPH LGEITCGTLL EKLQEIWDEV GESDDERDKL LLQIEQECLD VYKRKVEQAA
70 80 90 100 110 120
KSRAELLQTL SDANAELSSL TMSLGDKSLV GIPDKSSGTI KEQLAAIAPA LEQLWQQKEE
130 140 150 160 170 180
RVREFSDVQS QIQKICGDIA GGLSNEVPIV DESDLSLKKL DDFQSQLQEL QKEKSDRLRK
190 200 210 220 230 240
VLEFVSTVHD LCAVLGLDFL STVTEVHPSL DEDTSVQSKS ISNETLSRLA KTVLTLKDDK
250 260 270 280 290 300
KQRLQKLQEL ATQLIDLWNL MDTPDEEREL FDHVTCNISS SVDEVTVPGA LARDLIEQAE
310 320 330 340 350 360
VEVDRLDQLK ASRMKEIAFK KQSELEEIYA RAHVEVNPES ARERIMSLID SGNVEPTELL
370 380 390 400 410 420
ADMDSQISKA KEEAFSRKDI LDRVEKWMSA CEEESWLEDY NRDQNRYSAS RGAHLNLKRA
430 440 450 460 470 480
EKARILVSKI PAMVDTLVAK TRAWEEEHSM SFAYDGVPLL AMLDEYGMLR QEREEEKRRL
490 500 510 520 530 540
REQKKVQEQP HVEQESAFST RPSPARPVSA KKTVGPRANN GGANGTHNRR LSLNANQNGS
550 560 570 580
RSTAKEAGRR ETLNRPAAPT NYVAISKEEA ASSPVSGAAD HQVPASP