Q9ZRP7

PR
Gene name
SLD1 (At3g61580, F2A19.180)
Protein name
Delta(8)-fatty-acid desaturase 1
Names
Delta(8)-sphingolipid desaturase 1, Sphingoid long-chain base desaturase 1, Sphingoid LCB desaturase 1, Sphingolipid 8-(E/Z)-desaturase 1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G61580
EC number
1.14.19.29: With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

51-131 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9ZRP7

Entry ID Method Resolution Chain Position Source
AF-Q9ZRP7-F1 Predicted AlphaFoldDB

14 variants for Q9ZRP7

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH06356060 16 K>N No 1000Genomes
ENSVATH06356061 37 D>N No 1000Genomes
ENSVATH14466401 68 T>I No 1000Genomes
tmp_3_22786496_A_G 82 I>V No 1000Genomes
ENSVATH14466402 130 Y>F No 1000Genomes
tmp_3_22786679_A_T 143 I>F No 1000Genomes
ENSVATH06356062 171 K>E No 1000Genomes
tmp_3_22786794_C_T 181 S>F No 1000Genomes
tmp_3_22787114_G_A 288 A>T No 1000Genomes
ENSVATH06356065 308 P>S No 1000Genomes
ENSVATH02534905 317 S>G No 1000Genomes
tmp_3_22787349_G_T 366 W>L No 1000Genomes
ENSVATH06356067 431 D>N No 1000Genomes
ENSVATH12872188 438 K>E No 1000Genomes

No associated diseases with Q9ZRP7

2 regional properties for Q9ZRP7

Type Name Position InterPro Accession
domain Cytochrome b5-like heme/steroid binding domain 7 - 86 IPR001199
domain Fatty acid desaturase domain 142 - 408 IPR005804

Functions

Description
EC Number 1.14.19.29 With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water.
sphingolipid delta-8 desaturase activity Catalysis of the formation of a double bond between C8 and C9 of the long chain base of a sphingolipid. For example, sphinganine (d18:0) = 8-sphingenine (d18:1delta8); phytosphinganine (t18:0) = 8-phytosphingenine (t18:1delta8); and 4-sphingenine (18:1delta4) = 4,8-sphingadienine (d18:2delta4,8).

3 GO annotations of biological process

Name Definition
cellular response to cold Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
sphingolipid biosynthetic process The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9Z122 Fads2 Acyl-CoA 6-desaturase Rattus norvegicus (Rat) PR
Q9DEX7 fads2 Acyl-CoA 6-desaturase Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MAEETEKKYI TNEDLKKHNK SGDLWIAIQG KVYNVSDWIK THPGGDTVIL NLVGQDVTDA
70 80 90 100 110 120
FIAFHPGTAW HHLDHLFTGY HIRDFQVSEV SRDYRRMAAE FRKLGLFENK GHVTLYTLAF
130 140 150 160 170 180
VAAMFLGVLY GVLACTSVFA HQIAAALLGL LWIQSAYIGH DSGHYVIMSN KSYNRFAQLL
190 200 210 220 230 240
SGNCLTGISI AWWKWTHNAH HLACNSLDYD PDLQHIPVFA VSTKFFSSLT SRFYDRKLTF
250 260 270 280 290 300
DPVARFLVSY QHFTYYPVMC FGRINLFIQT FLLLFSKREV PDRALNFAGI LVFWTWFPLL
310 320 330 340 350 360
VSCLPNWPER FFFVFTSFTV TALQHIQFTL NHFAADVYVG PPTGSDWFEK QAAGTIDISC
370 380 390 400 410 420
RSYMDWFFGG LQFQLEHHLF PRLPRCHLRK VSPVVQELCK KHNLPYRSMS WFEANVLTIN
430 440
TLKTAAYQAR DVANPVVKNL VWEALNTHG