Q9DEX7

PR
Gene name
fads2 (fadsd6)
Protein name
Acyl-CoA 6-desaturase
Names
Delta(5)/Delta(6) fatty acid desaturase, D5D/D6D fatty acid desaturase, Delta-5/Delta-6 fatty acid desaturase, Fatty acid desaturase 2
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:140615
EC number
1.14.19.3: With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9DEX7

Entry ID Method Resolution Chain Position Source
AF-Q9DEX7-F1 Predicted AlphaFoldDB

No variants for Q9DEX7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9DEX7

No associated diseases with Q9DEX7

2 regional properties for Q9DEX7

Type Name Position InterPro Accession
domain Cytochrome b5-like heme/steroid binding domain 18 - 95 IPR001199
domain Fatty acid desaturase domain 157 - 416 IPR005804

Functions

Description
EC Number 1.14.19.3 With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
acyl-CoA delta5-desaturase activity Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = delta5-acyl-CoA + acceptor + 2 H2O.
linoleoyl-CoA desaturase activity Catalysis of the reaction: linoleoyl-CoA + reduced acceptor + O2 = gamma-linolenoyl-CoA + acceptor + 2 H2O.
oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water.

3 GO annotations of biological process

Name Definition
lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
liver development The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
unsaturated fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9Z122 Fads2 Acyl-CoA 6-desaturase Rattus norvegicus (Rat) PR
Q9ZRP7 SLD1 Delta(8)-fatty-acid desaturase 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGGGGQQTDR ITDTNGRFSS YTWEEVQKHT KHGDQWVVVE RKVYNVSQWV KRHPGGLRIL
70 80 90 100 110 120
GHYAGEDATE AFTAFHPNLQ LVRKYLKPLL IGELEASEPS QDRQKNAALV EDFRALRERL
130 140 150 160 170 180
EAEGCFKTQP LFFALHLGHI LLLEAIAFMM VWYFGTGWIN TLIVAVILAT AQSQAGWLQH
190 200 210 220 230 240
DFGHLSVFKT SGMNHLVHKF VIGHLKGASA GWWNHRHFQH HAKPNIFKKD PDVNMLNAFV
250 260 270 280 290 300
VGNVQPVEYG VKKIKHLPYN HQHKYFFFIG PPLLIPVYFQ FQIFHNMISH GMWVDLLWCI
310 320 330 340 350 360
SYYVRYFLCY TQFYGVFWAI ILFNFVRFME SHWFVWVTQM SHIPMNIDYE KNQDWLSMQL
370 380 390 400 410 420
VATCNIEQSA FNDWFSGHLN FQIEHHLFPT VPRHNYWRAA PRVRALCEKY GVKYQEKTLY
430 440
GAFADIIRSL EKSGELWLDA YLNK