Q9ZPI5
PR
Gene name |
MFP2 |
Protein name |
Peroxisomal fatty acid beta-oxidation multifunctional protein MFP2 |
Names |
AtMPF2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G06860 |
EC number |
1.1.1.35: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q9ZPI5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2WTB | X-ray | 250 A | A | 1-725 | PDB |
| AF-Q9ZPI5-F1 | Predicted | AlphaFoldDB |
25 variants for Q9ZPI5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_2161968_G_A | 15 | G>S | No | 1000Genomes | |
| tmp_3_2162578_A_G | 85 | K>R | No | 1000Genomes | |
| tmp_3_2163360_C_A | 191 | A>E | No | 1000Genomes | |
| ENSVATH02120156 | 206 | G>E | No | 1000Genomes | |
| tmp_3_2163416_C_T | 210 | P>S | No | 1000Genomes | |
| ENSVATH05787442 | 212 | V>L | No | 1000Genomes | |
| ENSVATH05787443 | 213 | S>C | No | 1000Genomes | |
| ENSVATH05787445 | 260 | V>I | No | 1000Genomes | |
| tmp_3_2163570_C_G | 261 | S>C | No | 1000Genomes | |
| tmp_3_2163732_T_G | 281 | D>E | No | 1000Genomes | |
| ENSVATH10534407 | 368 | M>L | No | 1000Genomes | |
| tmp_3_2164267_G_A | 392 | V>M | No | 1000Genomes | |
| tmp_3_2164480_A_G | 430 | I>V | No | 1000Genomes | |
| tmp_3_2164666_T_G | 455 | H>Q | No | 1000Genomes | |
| tmp_3_2164766_G_C | 489 | V>L | No | 1000Genomes | |
| ENSVATH05787457 | 521 | L>V | No | 1000Genomes | |
| tmp_3_2165243_C_T | 594 | A>V | No | 1000Genomes | |
| tmp_3_2165417_C_T | 620 | A>V | No | 1000Genomes | |
| tmp_3_2165494_G_A | 646 | G>S | No | 1000Genomes | |
| tmp_3_2165512_G_A | 652 | A>T | No | 1000Genomes | |
| ENSVATH05787464 | 678 | I>V | No | 1000Genomes | |
| ENSVATH00310252 | 696 | E>D | No | 1000Genomes | |
| tmp_3_2165774_G_A | 707 | R>K | No | 1000Genomes | |
| ENSVATH05787465 | 712 | V>I | No | 1000Genomes | |
| ENSVATH00310253 | 713 | L>P | No | 1000Genomes |
No associated diseases with Q9ZPI5
No regional properties for Q9ZPI5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9ZPI5 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 1.1.1.35 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| glyoxysome | A specialized form of peroxisome that contains the enzymes of the glyoxylate pathway. The glyoxysome is found in some plant cells, notably the cells of germinating seeds. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| peroxisome | A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. |
| plant-type cell wall | A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. |
| plasmodesma | A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3-hydroxyacyl-CoA dehydrogenase activity | Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+). |
| 3-hydroxybutyryl-CoA epimerase activity | Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA. |
| delta(3)-delta(2)-enoyl-CoA isomerase activity | Catalysis of the reactions: a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA or a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA. |
| enoyl-CoA hydratase activity | Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O. |
| long-chain-enoyl-CoA hydratase activity | Catalysis of the reaction: a long-chain (3S)-3-hydroxyacyl-CoA = a long-chain trans-2-enoyl-CoA + H2O. A long-chain acyl-CoA is an acyl-CoA thioester where the acyl chain contains 13 to 22 carbon atoms. |
| NAD+ binding | Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| fatty acid beta-oxidation | A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q39659 | Glyoxysomal fatty acid beta-oxidation multifunctional protein MFP-a | Cucumis sativus (Cucumber) | PR | |
| P42126 | ECI1 | Enoyl-CoA delta isomerase 1, mitochondrial | Homo sapiens (Human) | PR |
| Q08426 | EHHADH | Peroxisomal bifunctional enzyme | Homo sapiens (Human) | PR |
| P23965 | Eci1 | Enoyl-CoA delta isomerase 1, mitochondrial | Rattus norvegicus (Rat) | PR |
| Q8W1L6 | MFP | Peroxisomal fatty acid beta-oxidation multifunctional protein | Oryza sativa subsp japonica (Rice) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDSRTKGKTV | MEVGGDGVAV | ITLINPPVNS | LSFDVLYNLK | SNYEEALSRN | DVKAIVITGA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KGRFSGGFDI | SGFGEMQKGN | VKEPKAGYIS | IDIITDLLEA | ARKPSVAAID | GLALGGGLEL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AMACHARISA | PAAQLGLPEL | QLGVIPGFGG | TQRLPRLVGL | TKALEMILTS | KPVKAEEGHS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LGLIDAVVPP | AELVTTARRW | ALDIVGRRKP | WVSSVSKTDK | LPPLGEAREI | LTFAKAQTLK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RAPNMKHPLM | CLDAIEVGIV | SGPRAGLEKE | AEVASQVVKL | DTTKGLIHVF | FSQRGTAKVP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GVTDRGLVPR | KIKKVAIIGG | GLMGSGIATA | LILSNYPVIL | KEVNEKFLEA | GIGRVKANLQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SRVRKGSMSQ | EKFEKTMSLL | KGSLDYESFR | DVDMVIEAVI | ENISLKQQIF | ADLEKYCPQH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CILASNTSTI | DLNKIGERTK | SQDRIVGAHF | FSPAHIMPLL | EIVRTNHTSA | QVIVDLLDVG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KKIKKTPVVV | GNCTGFAVNR | MFFPYTQAAM | FLVECGADPY | LIDRAISKFG | MPMGPFRLCD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LVGFGVAIAT | ATQFIENFSE | RTYKSMIIPL | MQEDKRAGEA | TRKGFYLYDD | KRKAKPDPEL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KKYIEKARSI | SGVKLDPKLA | NLSEKDIIEM | TFFPVVNEAC | RVFAEGIAVK | AADLDIAGIM |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GMGFPPYRGG | IMFWADSIGS | KYIYSRLDEW | SKAYGEFFKP | CAFLAERGSK | GVLLSAPVKQ |
| ASSRL |