P23965

PR
Gene name
Eci1
Protein name
Enoyl-CoA delta isomerase 1, mitochondrial
Names
MECI, 3,2-trans-enoyl-CoA isomerase, Delta(3),Delta(2)-enoyl-CoA isomerase, D3,D2-enoyl-CoA isomerase, Dodecenoyl-CoA isomerase
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
5.3.3.8: Transposing C=C bonds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-59 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P23965

Entry ID Method Resolution Chain Position Source
1XX4 X-ray 220 A A 29-289 PDB
AF-P23965-F1 Predicted AlphaFoldDB

No variants for P23965

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P23965

No associated diseases with P23965

1 regional properties for P23965

Type Name Position InterPro Accession
conserved_site Enoyl-CoA hydratase/isomerase, conserved site 130 - 150 IPR018376

Functions

Description
EC Number 5.3.3.8 Transposing C=C bonds
Subcellular Localization
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

4 GO annotations of molecular function

Name Definition
delta(3)-delta(2)-enoyl-CoA isomerase activity Catalysis of the reactions: a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA or a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA.
enoyl-CoA hydratase activity Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O.
identical protein binding Binding to an identical protein or proteins.
intramolecular oxidoreductase activity, transposing C=C bonds Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears.

1 GO annotations of biological process

Name Definition
fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q39659 Glyoxysomal fatty acid beta-oxidation multifunctional protein MFP-a Cucumis sativus (Cucumber) PR
Q08426 EHHADH Peroxisomal bifunctional enzyme Homo sapiens (Human) PR
P42126 ECI1 Enoyl-CoA delta isomerase 1, mitochondrial Homo sapiens (Human) PR
Q8W1L6 MFP Peroxisomal fatty acid beta-oxidation multifunctional protein Oryza sativa subsp japonica (Rice) PR
Q9ZPI5 MFP2 Peroxisomal fatty acid beta-oxidation multifunctional protein MFP2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MALAAARRVL LQAGSRLGRR GAVDGARRFS NKRVLVEKEG EAGIAVMKFK NPPVNSLSLE
70 80 90 100 110 120
FLTEFVISLE KLENDKSIRG VILTSERPGI FSAGLDLMEM YGRNPAHYAE YWKAVQELWL
130 140 150 160 170 180
RLYLSNLTLI SAINGASPAG GCLMALTCDY RIMADNSKYT IGLNESLLGI VAPFWLKDNY
190 200 210 220 230 240
VNTIGHRAAE RALQLGTLFP PAEALKVGLV DEVVPEDQVH SKARSVMAKW FTIPDHSRQL
250 260 270 280
TKSMMRKATA DNLIKQREAD IQNFTSFISR DSIQKSLHVY LEKLKQKKG