Q9Z2L6

PR
Gene name
Minpp1 (Mipp, MNCb-1572)
Protein name
Multiple inositol polyphosphate phosphatase 1
Names
2,3-bisphosphoglycerate 3-phosphatase, 2,3-BPG phosphatase, Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase, Ins(1,3,4,5)P(4) 3-phosphatase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:17330
EC number
3.1.3.62: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-67 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9Z2L6

Entry ID Method Resolution Chain Position Source
AF-Q9Z2L6-F1 Predicted AlphaFoldDB

13 variants for Q9Z2L6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs583390138 115 R>W No EVA
rs217762738 211 G>D No EVA
rs233279544 257 K>Q No EVA
rs251568825 267 M>V No EVA
rs3407187100 277 V>K* No EVA
rs3389482335 323 Y>F No EVA
rs3389536442 323 Y>N No EVA
rs214988908 346 E>D No EVA
rs3389535683 364 H>Q No EVA
rs3389513867 399 S>G No EVA
rs582161621 418 N>S No EVA
rs3389549848 435 K>M No EVA
rs3389527043 456 Y>S No EVA

No associated diseases with Q9Z2L6

No regional properties for Q9Z2L6

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9Z2L6

Functions

Description
EC Number 3.1.3.62 Phosphoric monoester hydrolases
Subcellular Localization
  • Endoplasmic reticulum lumen
  • Secreted
  • Cell membrane
  • Also associated with the plasma membrane in erythrocytes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum lumen The volume enclosed by the membranes of the endoplasmic reticulum.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

6 GO annotations of molecular function

Name Definition
acid phosphatase activity Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum.
bisphosphoglycerate 3-phosphatase activity Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = 2-phospho-D-glycerate + phosphate.
inositol hexakisphosphate 2-phosphatase activity Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate.
inositol phosphate phosphatase activity Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate.
inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate.
inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UNW1 MINPP1 Multiple inositol polyphosphate phosphatase 1 Homo sapiens (Human) PR
O35217 Minpp1 Multiple inositol polyphosphate phosphatase 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MLRGARSHLP ASVAPAAVLA AALLSSFARC SLPGRGDPVA SVLSPYFGTK TRYEDANPWL
70 80 90 100 110 120
LVDPVAPRRD PELLAGTCTP VQLVALIRHG TRYPTTKQIR KLKQLQGLLQ TRESRDGGSQ
130 140 150 160 170 180
VAAALAEWPL WYGDWMDGQL VEKGRQDMRQ LALRLAALFP DLFSRENYDR LRLITSSKHR
190 200 210 220 230 240
CVDSSAAFLQ GLWQHYHPGL PPPDVSDMEC GPPRINDKLM RFFDHCEKFL TDVERNETAL
250 260 270 280 290 300
YHVEAFKTGP EMQKVLKKVA ATLQVPMNSL NADLIQVAFF TCSFDLAIKG VHSPWCDVFD
310 320 330 340 350 360
VDDARVLEYL NDLKQYWKRS YGYTINSRSS CNLFQDIFLH LDKAVEQKQR SQPVSSPVIL
370 380 390 400 410 420
QFGHAETLLP LLSLMGYFKD KEPLTAYNFE EQVNRKFRSG HIVPYASNLI FVLYHCDNAQ
430 440 450 460 470 480
SPEEQFQIQL LLNEKVLPLA HSQRPVGLYE ELKTHYRDIL QSCQTSKECS PPKANITSDE
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