O35217

PR
Gene name
Minpp1 (Mipp1)
Protein name
Multiple inositol polyphosphate phosphatase 1
Names
2,3-bisphosphoglycerate 3-phosphatase, 2,3-BPG phosphatase, Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase, Ins(1,3,4,5)P(4) 3-phosphatase
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:29688
EC number
3.1.3.62: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-59 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O35217

Entry ID Method Resolution Chain Position Source
AF-O35217-F1 Predicted AlphaFoldDB

No variants for O35217

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O35217

No associated diseases with O35217

No regional properties for O35217

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O35217

Functions

Description
EC Number 3.1.3.62 Phosphoric monoester hydrolases
Subcellular Localization
  • Endoplasmic reticulum lumen
  • Secreted
  • Cell membrane
  • Also associated with the plasma membrane in erythrocytes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
endoplasmic reticulum lumen The volume enclosed by the membranes of the endoplasmic reticulum.

6 GO annotations of molecular function

Name Definition
acid phosphatase activity Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum.
bisphosphoglycerate 3-phosphatase activity Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = 2-phospho-D-glycerate + phosphate.
inositol hexakisphosphate 2-phosphatase activity Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate.
inositol phosphate phosphatase activity Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate.
inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate.
inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate.

1 GO annotations of biological process

Name Definition
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UNW1 MINPP1 Multiple inositol polyphosphate phosphatase 1 Homo sapiens (Human) PR
Q9Z2L6 Minpp1 Multiple inositol polyphosphate phosphatase 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MLRGARSHLS ASVALAAVLA AALLSSFARC SLPGRGDPVA SVLSPYFGTK TRYEDVNPWL
70 80 90 100 110 120
LGDPVAPRRD PELLAGTCTP VQLVALIRHG TRYPTTKQIR KLRQLQGLLQ TRESVDGGSR
130 140 150 160 170 180
VAAALDQWPL WYDDWMDGQL VEKGRQDMRQ LALRLAALFP DLFCRENYGR LRLITSSKHR
190 200 210 220 230 240
CVDSSAAFLQ GLWQHYHPGL PPPDVSDMEC DPPRVNDKLM RFFDHCEKFL TEVERNATAL
250 260 270 280 290 300
YHVEAFKTGP EMQTVLKKVA ATLQVPVNNL NADLIQVAFF TCSFDLAIQG VHSPWCDVFD
310 320 330 340 350 360
VDDAKVLEYL NDLKQYWKRS YGYAINSRSS CNLFQDIFLH LDKAVEQKQR SQPVSSSVIL
370 380 390 400 410 420
QFGHAETLLP LLSLMGYFKD KEPLTAYNFE EQVHREFRSG HIVPYASNLI FVLYHCEDAQ
430 440 450 460 470 480
TPQEKFQIQM LLNEKVLPLA HSQKTVALYE DLKNHYQDIL QSCQTSKECN LPKVNITSDE
L