Q9Z2E5

PR
Gene name
Atoh7
Protein name
Transcription factor Atoh7
Names
Atonal bHLH transcription factor 7, Helix-loop-helix protein mATH-5, mATH5, Protein atonal homolog 7
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:53404
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-62 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9Z2E5

Entry ID Method Resolution Chain Position Source
AF-Q9Z2E5-F1 Predicted AlphaFoldDB

4 variants for Q9Z2E5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs254897531 14 A>P No EVA
rs236000749 16 G>V No EVA
rs256117038 19 P>A No EVA
rs231438363 124 A>S No EVA

No associated diseases with Q9Z2E5

1 regional properties for Q9Z2E5

Type Name Position InterPro Accession
conserved_site Di-trans-poly-cis-decaprenylcistransferase-like, conserved site 245 - 262 IPR018520

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Perikaryon
  • Cell projection, axon
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perikaryon The portion of the cell soma (neuronal cell body) that excludes the nucleus.

5 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific double-stranded DNA binding Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.
transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

10 GO annotations of biological process

Name Definition
circadian rhythm Any biological process in an organism that recurs with a regularity of approximately 24 hours.
entrainment of circadian clock The synchronization of a circadian rhythm to environmental time cues such as light.
entrainment of circadian clock by photoperiod The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
neural retina development The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.
neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron.
optic nerve development The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.
positive regulation of retinal ganglion cell axon guidance Any process that activates or increases the frequency, rate or extent of retinal ganglion cell axon guidance.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to auditory stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P70447 Neurog2 Neurogenin-2 Mus musculus (Mouse) PR
10 20 30 40 50 60
MKSACKPHGP PAGARGAPPC AGAAERAVSC AGPGRLESAA RRRLAANARE RRRMQGLNTA
70 80 90 100 110 120
FDRLRRVVPQ WGQDKKLSKY ETLQMALSYI IALTRILAEA ERDWVGLRCE QRGRDHPYLP
130 140
FPGARLQVDP EPYGQRLFGF QPEPFPMAS