AiPD: Autoinhibited Protein Database

Gene name	Phf1 (Plc1, Tctex-3, Tctex3)
Protein name	PHD finger protein 1
Names	Protein PHF1, Polycomb-like protein 1, mPCl1, T-complex testis-expressed 3
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:21652
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

333-552 (Predicted disordered autoinhibitory region) PR

333-552 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
5XFQ	X-ray	240 A	A/B	25-360	PDB
AF-Q9Z1B8-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389426167	9	R>S	No	EVA
rs3389395747	53	K>R	No	EVA
rs3407445035	57	A>D	No	EVA
rs3407609779	61	C>G	No	EVA
rs3389456756	76	K>N	No	EVA
rs3389438323	80	P>L	No	EVA
rs3389359159	97	T>N	No	EVA
rs3389437718	104	L>P	No	EVA
rs3389445100	108	E>K	No	EVA
rs3407457700	156	Y>H	No	EVA
rs3389395695	158	R>L	No	EVA
rs3407191363	160	M>I	No	EVA
rs3411602239	239	G>S	No	EVA
rs3389448673	299	G>E	No	EVA
rs3389451669	301	R>H	No	EVA
rs3389445140	384	V>L	No	EVA
rs3405739031	421	E>V	No	EVA
rs3407876148	459	D>N	No	EVA
rs3389456792	484	H>Q	No	EVA
rs3389448651	498	P>L	No	EVA
rs3389462743	532	D>N	No	EVA
rs3389445810	540	R>K	No	EVA
rs3406541347	557	G>S	No	EVA
rs3407609789	558	I>R	No	EVA

Type	Name	Position	InterPro Accession
domain	Zinc finger, PHD-type	89 - 140	IPR001965-1
domain	Zinc finger, PHD-type	188 - 238	IPR001965-2
domain	Tudor domain	29 - 86	IPR002999
conserved_site	Zinc finger, PHD-type, conserved site	90 - 139	IPR019786
domain	Zinc finger, PHD-finger	87 - 142	IPR019787
domain	Polycomb-like MTF2 factor 2, C-terminal domain	528 - 556	IPR025894
domain	PHD finger protein 1, PHD finger 1	89 - 139	IPR031202
domain	Lysine-specific demethylase 4-like, Tudor domain	34 - 69	IPR040477
domain	PHD finger protein 1, PHD finger 2	188 - 239	IPR047010
domain	PHD finger protein 1, Tudor domain	30 - 82	IPR047399

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome	Localizes specifically to the promoters of numerous target genes Localizes to double-strand breaks (DSBs) sites following DNA damage Colocalizes with NEK6 in the centrosome (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
ESC/E(Z) complex	A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
site of double-strand break	A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
histone methyltransferase binding	Binding to a histone methyltransferase enzyme.
identical protein binding	Binding to an identical protein or proteins.
metal ion binding	Binding to a metal ion.
methylated histone binding	Binding to a histone in which a residue has been modified by methylation.
transcription corepressor binding	Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.

Name	Definition
cellular response to DNA damage stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
chromatin organization	The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
negative regulation of histone H3-K27 methylation	Any process that decreases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone.
positive regulation of histone H3-K27 methylation	Any process that increases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone.
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9Y483	MTF2	Metal-response element-binding transcription factor 2	Homo sapiens (Human)	PR
O43189	PHF1	PHD finger protein 1	Homo sapiens (Human)	PR
Q02395	Mtf2	Metal-response element-binding transcription factor 2	Mus musculus (Mouse)	PR