AiPD: Autoinhibited Protein Database

Q9Y605

Gene name	MRFAP1
Protein name	MORF4 family-associated protein 1
Names	Protein PGR1, Protein associated with MRG of 14 kDa
Species	Homo sapiens (Human)
KEGG Pathway	hsa:93621
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-127 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-127 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9Y605

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9Y605-F1	Predicted				AlphaFoldDB

108 variants for Q9Y605

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs772362053 CA2841614	2	R>W		No	ClinGen ExAC gnomAD
rs773553368 CA356188845	4	L>V		No	ClinGen ExAC TOPMed gnomAD
rs747445625 CA2841616	6	I>M		No	ClinGen ExAC gnomAD
rs1461776413 CA356188876	7	V>L		No	ClinGen gnomAD
rs868476557 CA91847648	10	A>V		No	ClinGen Ensembl
rs1374785752 CA356188909	11	E>A		No	ClinGen TOPMed gnomAD
rs1374785752 CA356188910	11	E>V		No	ClinGen TOPMed gnomAD
rs1444814864 CA356188924	12	P>L		No	ClinGen TOPMed
rs1160534700 CA356188932	13	E>A		No	ClinGen gnomAD
CA91847662 rs202160929	13	E>Q		No	ClinGen TOPMed
rs11537685 CA91847689	15	V>E		No	ClinGen 1000Genomes
rs11537685 CA91847706	15	V>G		No	ClinGen 1000Genomes
rs1577307006 CA356188978	17	V>G		No	ClinGen Ensembl
CA2841624 rs750076071	19	E>Q		No	ClinGen ExAC gnomAD
CA356189000 rs1380000413	20	P>S		No	ClinGen gnomAD
CA2841627 rs753836065	21	E>Q		No	ClinGen ExAC gnomAD
CA2841629 rs779056217	27	F>Y		No	ClinGen ExAC TOPMed gnomAD
CA356189111 rs1577307030	31	V>G		No	ClinGen Ensembl
CA356189128 rs1203323255	33	N>S		No	ClinGen gnomAD
CA2841631 rs758545780	35	M>I		No	ClinGen ExAC gnomAD
rs1178240560 CA356189189	39	I>V		No	ClinGen gnomAD
rs916310316 CA356189198	40	A>S		No	ClinGen TOPMed
rs916310316 CA91847799	40	A>T		No	ClinGen TOPMed
rs1029150677 CA91847826	41	S>*		No	ClinGen Ensembl
rs947847923 CA91847812	41	S>A		No	ClinGen TOPMed gnomAD
rs1430476737 CA356189228	43	T>M		No	ClinGen gnomAD
CA2841635 rs776816659	46	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs746387796 CA2841636	48	R>L		No	ClinGen ExAC
rs1372504794 CA356189294	50	Y>F		No	ClinGen gnomAD
CA2841638 rs530805744	51	L>P		No	ClinGen 1000Genomes ExAC gnomAD
rs1324067697 CA356189323	53	N>K		No	ClinGen gnomAD
CA2841639 rs761381560	53	N>T		No	ClinGen ExAC gnomAD
rs766987420 CA91847843	54	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1250896241 CA356189368	58	W>L		No	ClinGen gnomAD
rs1479925763 CA356189377	59	E>K		No	ClinGen gnomAD
CA356189378 rs1479925763	59	E>Q		No	ClinGen gnomAD
CA356189392 rs1202285685	60	M>L		No	ClinGen gnomAD
CA2841645 rs758663636	62	N>S		No	ClinGen ExAC TOPMed gnomAD
rs758599781 CA2841648	63	M>I		No	ClinGen ExAC gnomAD
CA2841647 rs752649249	63	M>T		No	ClinGen ExAC gnomAD
CA91847901 rs918376402	63	M>V		No	ClinGen gnomAD
CA91847907 rs1036300699	64	L>F		No	ClinGen TOPMed gnomAD
rs1036300699 CA356189439	64	L>V		No	ClinGen TOPMed gnomAD
rs757485811 CA2841651	68	K>*		No	ClinGen ExAC gnomAD
CA356189488 rs1243079171	68	K>R		No	ClinGen gnomAD
CA91847922 rs981270371	69	T>M		No	ClinGen gnomAD
rs1364334480 CA356189524	72	E>K		No	ClinGen gnomAD
rs1294915433 CA356189551	74	S>L		No	ClinGen gnomAD
TCGA novel	77	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1225316673 CA356189597	78	A>S		No	ClinGen gnomAD
rs143781974 CA2841653	78	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA2841657 rs376105401	79	L>F		No	ClinGen ESP ExAC TOPMed
CA356189626 rs772670195	81	H>P		No	ClinGen ExAC gnomAD
CA2841660 rs772670195	81	H>R		No	ClinGen ExAC gnomAD
CA91848040 rs11537686	83	Q>H		No	ClinGen Ensembl
CA356189652 rs1220145697	84	N>D		No	ClinGen TOPMed
rs142456119 CA2841663	85	P>A		No	ClinGen ESP ExAC gnomAD
CA2841664 rs146471805	85	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA91848050 rs142456119	85	P>S		No	ClinGen ESP ExAC gnomAD
CA356189667 rs1424002241	86	G>S		No	ClinGen gnomAD
rs781153322 CA91848071	87	D>G		No	ClinGen Ensembl
rs752703537 CA2841666	87	D>N		No	ClinGen ExAC TOPMed
rs764270385 CA2841668	90	E>D		No	ClinGen ExAC gnomAD
CA356189709 rs1269861697	90	E>K		No	ClinGen gnomAD
rs751629143 CA356189734	92	R>L		No	ClinGen ExAC TOPMed gnomAD
rs751629143 CA2841669	92	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs139039647 CA91848089	93	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs139039647 CA2841670	93	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs756488660 CA2841673	94	A>G		No	ClinGen ExAC gnomAD
CA2841672 rs529892353	94	A>P		No	ClinGen 1000Genomes ExAC gnomAD
rs529892353 CA356189744	94	A>S		No	ClinGen 1000Genomes ExAC gnomAD
CA2841671 COSM588047 rs529892353	94	A>T	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
rs756488660 CA356189745	94	A>V		No	ClinGen ExAC gnomAD
rs1358775793 CA356189751	95	K>E		No	ClinGen TOPMed
rs780421191 CA356189754	95	K>R		No	ClinGen ExAC gnomAD
rs780421191 CA2841674	95	K>T		No	ClinGen ExAC gnomAD
rs377063696 CA91848130	96	R>S		No	ClinGen ESP TOPMed gnomAD
CA356189791 rs1241162488	98	E>D		No	ClinGen gnomAD
CA356189804 rs201872980	99	K>N		No	ClinGen ExAC gnomAD
CA356189795 rs1463119149	99	K>Q		No	ClinGen gnomAD
rs1385390631 CA356189812	100	A>V		No	ClinGen gnomAD
rs1161413659 CA356189823	101	E>D		No	ClinGen TOPMed gnomAD
TCGA novel	101	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA356189836 rs1409835547	102	E>D		No	ClinGen gnomAD
rs1016548821 CA91848133	102	E>G		No	ClinGen Ensembl
rs777280370 CA2841678	103	K>N		No	ClinGen ExAC TOPMed gnomAD
rs746588171 CA2841679	104	A>T		No	ClinGen ExAC gnomAD
COSM1430574 rs141440565 CA2841680	105	K>E	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA2841681 rs776194851	105	K>R		No	ClinGen ExAC gnomAD
rs759178401 CA2841682	106	E>K		No	ClinGen ExAC TOPMed gnomAD
CA2841683 rs769503832	107	I>M		No	ClinGen ExAC gnomAD
rs969078262 CA91848158	108	A>G		No	ClinGen TOPMed
rs1446405373 CA356189905	109	K>R		No	ClinGen gnomAD
CA2841684 rs775354541	110	M>V		No	ClinGen ExAC gnomAD
rs762995094 CA2841685	111	A>V		No	ClinGen ExAC gnomAD
CA2841686 rs150400295	113	M>L		No	ClinGen ESP ExAC gnomAD
CA2841687 rs751540717	114	L>V		No	ClinGen ExAC gnomAD
CA2841688 rs761842070 CA91848181	115	V>L		No	ClinGen ExAC TOPMed gnomAD
CA356189969 rs1350520760	116	E>Q		No	ClinGen TOPMed
rs375474191 CA91848197	117	L>M		No	ClinGen TOPMed gnomAD
rs1302102372 CA356189998	119	R>Q		No	ClinGen TOPMed gnomAD
CA356190002 rs1470503746	120	R>G		No	ClinGen gnomAD
CA2841692 rs766734285	121	I>L		No	ClinGen ExAC gnomAD
rs1471068213 CA356190021	122	E>Q		No	ClinGen gnomAD
rs866289712 CA91848231	123	K>E		No	ClinGen Ensembl
CA2841693 rs754145197	123	K>N		No	ClinGen ExAC TOPMed gnomAD
CA2841695 rs779435276	126	S>L		No	ClinGen ExAC gnomAD
CA2841696 rs748664722	127	S>W		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with Q9Y605

No regional properties for Q9Y605

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9Y605

Functions

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm, perinuclear region	Colocalizes with MORF4L1 to cell nuclei
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3ZC61	MRFAP1	MORF4 family-associated protein 1	Bos taurus (Bovine)	PR
Q96HT8	MRFAP1L1	MORF4 family-associated protein 1-like 1	Homo sapiens (Human)	PR
Q9CQL7	Mrfap1	MORF4 family-associated protein 1	Mus musculus (Mouse)	PR
Q5M820	Mrfap1	MORF4 family-associated protein 1	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MRPLDIVELA	EPEEVEVLEP	EEDFEQFLLP	VINEMREDIA	SLTREHGRAY	LRNRSKLWEM
70	80	90	100	110	120
DNMLIQIKTQ	VEASEESALN	HLQNPGDAAE	GRAAKRCEKA	EEKAKEIAKM	AEMLVELVRR

IEKSESS