AiPD: Autoinhibited Protein Database

Q9Y580

Gene name	RBM7
Protein name	RNA-binding protein 7
Names	RNA-binding motif protein 7
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10179
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

68-239 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

68-239 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

7 structures for Q9Y580

Entry ID	Method	Resolution	Chain	Position	Source
2M8H	NMR	-	A	6-94	PDB
5IQQ	X-ray	252 A	A/B/C/D/E	1-91	PDB
5LXR	X-ray	200 A	A	1-86	PDB
5LXY	X-ray	285 A	A/B/E/G/I/K/M	1-86	PDB
7S7B	EM	406 A	C/G	7-86	PDB
7S7C	EM	362 A	C	7-86	PDB
AF-Q9Y580-F1	Predicted				AlphaFoldDB

185 variants for Q9Y580

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs774329256 CA6285805	2	G>R		No	ClinGen ExAC gnomAD
CA382679524 rs1203693799	3	A>P		No	ClinGen TOPMed gnomAD
CA382679529 rs1448072131	4	A>T		No	ClinGen gnomAD
CA382679538 rs368320968	5	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs368320968 CA6285809	5	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs368320968 CA6285808	5	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA6285810 rs775080859	6	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1233892762 CA382679548	7	E>G		No	ClinGen TOPMed
rs1165949207 CA382679556	8	A>G		No	ClinGen gnomAD
rs1267361877 CA382679560	9	D>H		No	ClinGen gnomAD
rs376690569 CA6285812	10	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs376690569 CA382679566	10	R>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA382679567 rs143550249	10	R>H		No	ClinGen ESP ExAC gnomAD
rs143550249 CA6285814	10	R>L		No	ClinGen ESP ExAC gnomAD
CA6285813 rs376690569	10	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs190030485 CA6285817	11	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs148035426 CA6285818	11	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs190030485 CA382679569	11	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6285820 rs755231508	12	L>V		No	ClinGen ExAC gnomAD
rs11543047 CA228728258	13	F>L		No	ClinGen Ensembl
CA228728262 rs1033738658	14	V>M		No	ClinGen TOPMed gnomAD
rs749095109 CA6285822	15	G>S		No	ClinGen ExAC gnomAD
rs770762090 CA6285823	18	E>D		No	ClinGen ExAC gnomAD
CA228728274 rs958509263	20	K>T		No	ClinGen TOPMed
CA228728282 rs921940985	22	T>A		No	ClinGen gnomAD
rs921940985 CA382679635	22	T>S		No	ClinGen gnomAD
rs1298404811 CA382679740	35	P>S		No	ClinGen gnomAD
rs1369700835 CA382679748	36	V>A		No	ClinGen gnomAD
TCGA novel	38	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1246488532 CA382679768	38	K>Q		No	ClinGen gnomAD
CA6285846 rs768095341	41	I>T		No	ClinGen ExAC TOPMed gnomAD
CA6285848 rs747825571	43	K>T		No	ClinGen ExAC TOPMed gnomAD
rs1235710598 CA382679892	44	D>E		No	ClinGen gnomAD
rs1367559410 CA382679889	44	D>V		No	ClinGen TOPMed
rs1434378066 CA382679918	46	D>H		No	ClinGen TOPMed
rs1305853073 CA382680000	50	K>N		No	ClinGen gnomAD
rs1206633178 CA382680020	51	Q>H		No	ClinGen gnomAD
rs1343958427 CA382680141	58	K>R		No	ClinGen TOPMed
rs201324300 CA382680158	59	H>Q		No	ClinGen TOPMed gnomAD
CA6285850 rs766198070	65	Y>*		No	ClinGen ExAC gnomAD
CA382680269 COSM540903 rs1454517755	67	M>V	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA382680293 rs1185877114	68	N>S		No	ClinGen gnomAD
CA228728714 rs534184694	74	K>R		No	ClinGen 1000Genomes gnomAD
rs1025460990 CA228728717	75	L>F		No	ClinGen gnomAD
CA382680371 rs1025460990	75	L>V		No	ClinGen gnomAD
rs763477337 CA6285852	78	R>K		No	ClinGen ExAC TOPMed gnomAD
CA6285853 rs766894526	78	R>S		No	ClinGen ExAC gnomAD
VAR_082580	79	P>R	found in a patient with a form of spinal muscular atrophy; unknown pathological significance [UniProt]	No	UniProt
rs774769202 CA6285854	81	K>R		No	ClinGen ExAC TOPMed gnomAD
rs981241452 CA228728724	85	R>S		No	ClinGen Ensembl
rs767522434 CA382680444	86	S>P		No	ClinGen ExAC TOPMed gnomAD
CA6285856 rs767522434	86	S>T		No	ClinGen ExAC TOPMed gnomAD
CA6285875 rs775549354	88	S>N		No	ClinGen ExAC gnomAD
rs760804891 CA6285876	89	S>G		No	ClinGen ExAC gnomAD
CA6285877 rs764282163	90	H>R		No	ClinGen ExAC gnomAD
rs1223059411 CA382680802	92	P>L		No	ClinGen gnomAD
TCGA novel	94	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758154213 COSM1351425 CA6285880	96	S>G	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA6285881 rs766110528	96	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1484407503 CA382680894	97	L>F		No	ClinGen gnomAD
rs1256647768 CA382680889	97	L>W		No	ClinGen gnomAD
CA382681039 rs1466543835	107	S>P		No	ClinGen gnomAD
rs540109621 CA6285883	110	T>A		No	ClinGen 1000Genomes ExAC gnomAD
CA382681074 rs1406285510	112	T>I		No	ClinGen gnomAD
rs1159796541 CA382681080	113	S>F		No	ClinGen TOPMed gnomAD
rs748979044 CA6285888	114	P>S		No	ClinGen ExAC TOPMed gnomAD
rs553325407 CA228730221	116	R>S		No	ClinGen TOPMed gnomAD
rs528528235 CA6285903	117	Y>H		No	ClinGen 1000Genomes ExAC gnomAD
rs528528235 CA6285904	117	Y>N		No	ClinGen 1000Genomes ExAC gnomAD
CA6285907 rs756862051	118	E>G		No	ClinGen ExAC TOPMed gnomAD
rs753479874 CA6285906	118	E>K	Variant assessed as Somatic; 4.788e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs547208464 CA6285910	119	R>S		No	ClinGen 1000Genomes ExAC gnomAD
CA382681723 rs1274758320	120	T>I		No	ClinGen gnomAD
rs780501658 CA6285911	121	M>T		No	ClinGen ExAC gnomAD
CA228730269 rs777959689	121	M>V		No	ClinGen Ensembl
rs1199713420 CA382681735	122	D>G		No	ClinGen gnomAD
rs768664850 CA6285913	124	M>T		No	ClinGen ExAC gnomAD
rs1057166979 CA228730271	125	T>S		No	ClinGen Ensembl
CA6285914 rs776697572	126	S>L		No	ClinGen ExAC TOPMed gnomAD
CA382681781 rs1475165030	129	Q>R		No	ClinGen gnomAD
rs769897060 CA6285916	130	I>V		No	ClinGen ExAC gnomAD
rs1565261311 CA382681799	132	Q>E		No	ClinGen Ensembl
CA382681826 rs1466312246	135	F>L		No	ClinGen gnomAD
rs201717789 CA6285918	136	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA382681835 rs1447977095	137	S>Y		No	ClinGen TOPMed
COSM1561080 rs752632231 CA6285920	138	P>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs760698015 CA6285921	139	E>K		No	ClinGen ExAC gnomAD
rs1158677590 CA382681850	140	N>H		No	ClinGen TOPMed
TCGA novel	142	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6285922 rs763627981	144	Q>R		No	ClinGen ExAC gnomAD
CA382681896 COSM540902 rs1197876807	146	V>L	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1192298489 CA382681993	147	M>I		No	ClinGen TOPMed
CA382681982 rs1340620326	147	M>L		No	ClinGen gnomAD
rs760609996 CA6285943	150	A>S		No	ClinGen ExAC TOPMed gnomAD
CA6285944 rs565722182	154	M>I		No	ClinGen 1000Genomes ExAC gnomAD
CA382682130 rs1180690440	155	S>P		No	ClinGen TOPMed
rs776672227 CA6285945	156	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA382682207 rs1257810143	160	F>L		No	ClinGen TOPMed
CA6285946 rs761192208	162	S>P		No	ClinGen ExAC TOPMed gnomAD
CA6285947 rs764829483	162	S>Y		No	ClinGen ExAC gnomAD
rs1203923609 CA382682241	164	P>L		No	ClinGen gnomAD
CA382682252 rs1398698243	166	D>E		No	ClinGen gnomAD
rs758051944 CA382682248	166	D>N		No	ClinGen ExAC gnomAD
rs758051944 CA6285949	166	D>Y		No	ClinGen ExAC gnomAD
rs1425755491 CA382682335	172	P>L		No	ClinGen gnomAD
rs1188042796 CA382682356	174	V>I		No	ClinGen TOPMed gnomAD
rs1188042796 CA382682358	174	V>L		No	ClinGen TOPMed gnomAD
CA382682398 rs1363040917	176	S>*		No	ClinGen gnomAD
TCGA novel	178	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA382682459 rs1160238585	179	H>Q		No	ClinGen gnomAD
rs781519121 CA6285954	179	H>R		No	ClinGen ExAC gnomAD
CA382682463 rs1361017270	180	S>G		No	ClinGen gnomAD
rs368476669 CA6285955	182	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6285956 rs756098040	183	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1310520341 CA382682526	183	Q>R		No	ClinGen gnomAD
COSM125795 CA228731108 rs944272961	184	S>F	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1415539423 CA382682592	187	S>Y		No	ClinGen TOPMed
CA6285958 rs749400330	188	Q>R		No	ClinGen ExAC gnomAD
rs771270717 COSM923297 CA6285959	190	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs79339992 CA6285960	190	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs376442758 CA228731123	193	T>I		No	ClinGen ESP TOPMed gnomAD
rs537118955 CA6285961	194	P>S		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	195	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6285962 rs200274481	197	Q>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA382682711 rs1278240694	197	Q>R		No	ClinGen gnomAD
rs761823586 CA6285965	198	R>C		No	ClinGen ExAC TOPMed gnomAD
COSM295184 CA6285966 rs772778246	198	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs772778246 CA382682717	198	R>P		No	ClinGen ExAC TOPMed gnomAD
rs761823586 CA6285964	198	R>S		No	ClinGen ExAC TOPMed gnomAD
rs765997028 CA6285968	200	V>L		No	ClinGen ExAC gnomAD
rs1188201858 CA382682733	201	R>*		No	ClinGen TOPMed
CA6285970 rs748265184	201	R>S		No	ClinGen ExAC gnomAD
CA6285972 rs753084134	206	P>S		No	ClinGen ExAC gnomAD
CA382682782 rs1254683898	208	L>V		No	ClinGen TOPMed
CA382682787 rs1393867281	209	A>T		No	ClinGen gnomAD
CA228731170 rs767285454	209	A>V		No	ClinGen Ensembl
rs3781986 CA6285976	212	H>R		No	ClinGen ExAC TOPMed gnomAD
rs778209684 CA6285975	212	H>Y		No	ClinGen ExAC
CA6285978 rs779238918	215	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs142687993 CA6285977	215	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	216	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369282205 CA6285980	217	Q>*		No	ClinGen ESP ExAC gnomAD
TCGA novel	217	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6285981 rs11543050	218	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs772286712 CA6285982	218	R>H		No	ClinGen ExAC TOPMed gnomAD
CA228731201 rs11543050	218	R>S		No	ClinGen ExAC TOPMed gnomAD
rs539783045 CA6285983	220	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs111474125 CA228731216	221	D>G		No	ClinGen Ensembl
CA6285984 rs371576672	222	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA382682880 rs376078417	223	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs376078417 CA6285985	223	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs773941198 CA6285987	225	D>E		No	ClinGen ExAC gnomAD
RCV001091033 rs1946284961	226	H>R		No	ClinVar dbSNP
CA382682907 rs1427093587	227	H>R		No	ClinGen gnomAD
rs759196426 CA6285988	228	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1169112946 CA382682930	230	G>V		No	ClinGen gnomAD
rs1466838369 CA382682935	231	K>R		No	ClinGen TOPMed gnomAD
TCGA novel	232	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6285990 rs369732805	232	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel CA382682968 rs1478294996	235	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen gnomAD
CA6285991 rs753101100	237	Y>C		No	ClinGen ExAC gnomAD
CA382682981 rs753101100	237	Y>S		No	ClinGen ExAC gnomAD
CA382682990 rs879029123	238	E>D		No	ClinGen gnomAD
rs777999213 CA6285992	239	D>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	241	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6285994 rs764638996	242	H>R		No	ClinGen ExAC gnomAD
CA6285996 rs757365374	243	D>H		No	ClinGen ExAC gnomAD
CA382683030 rs1220718696	244	D>Y		No	ClinGen gnomAD
TCGA novel	246	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1474651341 CA382683057	247	H>R		No	ClinGen TOPMed
CA382683073 rs1467869611	249	Y>C		No	ClinGen gnomAD
rs750607699 CA382683082	250	D>E		No	ClinGen ExAC gnomAD
CA6285997 rs779148823	250	D>N		No	ClinGen ExAC gnomAD
TCGA novel	251	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758645695 CA6285999	252	R>K		No	ClinGen ExAC TOPMed gnomAD
rs758645695 CA382683094	252	R>T		No	ClinGen ExAC TOPMed gnomAD
rs747955530 CA6286001	256	S>G		No	ClinGen ExAC gnomAD
CA382683124 rs1241512547	256	S>T		No	ClinGen TOPMed
rs769519996 CA6286002	261	W>G		No	ClinGen ExAC gnomAD
CA6286003 rs373571346	262	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs749242719 CA6286004	262	R>H		No	ClinGen ExAC TOPMed gnomAD
CA382683174 rs1273539978	263	S>L		No	ClinGen TOPMed
rs541868847 CA6286005	264	S>F		No	ClinGen 1000Genomes ExAC gnomAD
CA382683185 rs1352159220	265	R>*		No	ClinGen gnomAD
rs199909173 CA228731292 COSM923298	265	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD

No associated diseases with Q9Y580

2 regional properties for Q9Y580

Type	Name	Position	InterPro Accession
domain	RNA recognition motif domain	10 - 87	IPR000504
domain	RBM7, RNA recognition motif	9 - 83	IPR034500

Functions

		Description
EC Number
Subcellular Localization	Nucleus, nucleoplasm Nucleus	Excluded from the nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name	Definition
14-3-3 protein binding	Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
pre-mRNA intronic binding	Binding to an intronic sequence of a pre-messenger RNA (pre-mRNA).
RNA binding	Binding to an RNA molecule or a portion thereof.
single-stranded RNA binding	Binding to single-stranded RNA.
snRNA binding	Binding to a small nuclear RNA (snRNA).

3 GO annotations of biological process

Name	Definition
meiotic cell cycle	Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
regulation of alternative mRNA splicing, via spliceosome	Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
snRNA catabolic process	The chemical reactions and pathways resulting in the breakdown of snRNA, small nuclear RNA, low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9CQT2	Rbm7	RNA-binding protein 7	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MGAAAAEADR	TLFVGNLETK	VTEELLFELF	HQAGPVIKVK	IPKDKDGKPK	QFAFVNFKHE
70	80	90	100	110	120
VSVPYAMNLL	NGIKLYGRPI	KIQFRSGSSH	APQDVSLSYP	QHHVGNSSPT	STSPSRYERT
130	140	150	160	170	180
MDNMTSSAQI	IQRSFSSPEN	FQRQAVMNSA	LRQMSYGGKF	GSSPLDQSGF	SPSVQSHSHS
190	200	210	220	230	240
FNQSSSSQWR	QGTPSSQRKV	RMNSYPYLAD	RHYSREQRYT	DHGSDHHYRG	KRDDFFYEDR
250	260
NHDDWSHDYD	NRRDSSRDGK	WRSSRH