AiPD: Autoinhibited Protein Database

Q9Y3F4

Gene name	STRAP (MAWD, UNRIP)
Protein name	Serine-threonine kinase receptor-associated protein
Names	MAP activator with WD repeats, UNR-interacting protein, WD-40 repeat protein PT-WD
Species	Homo sapiens (Human)
KEGG Pathway	hsa:11171
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

292-350 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

292-350 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9Y3F4

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9Y3F4-F1	Predicted				AlphaFoldDB

201 variants for Q9Y3F4

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs200335719 CA6468053	2	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA384057019 rs140693042	3	M>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6468054 rs140693042	3	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1229176360 CA384057030	4	R>K		No	ClinGen gnomAD
rs557894238 CA6468057	7	P>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA384057061 rs1259398089	9	T>N		No	ClinGen gnomAD
rs1591981324 CA384057058	9	T>P		No	ClinGen Ensembl
rs1259398089 CA384057062	9	T>S		No	ClinGen gnomAD
TCGA novel	11	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6468059 rs767606744	12	G>V		No	ClinGen ExAC gnomAD
CA384057089 rs1473659360	13	H>Q		No	ClinGen gnomAD
TCGA novel	13	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1474330710 CA384057109	17	V>L		No	ClinGen TOPMed gnomAD
CA384057117 rs1172990646	18	V>D		No	ClinGen gnomAD
TCGA novel	20	L>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1188443 CA6468060 rs773642778	23	S>G	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA6468061 rs761238306	23	S>N		No	ClinGen ExAC TOPMed gnomAD
CA6468062 rs144566765	24	G>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs763765976 CA6468065	28	Y>C		No	ClinGen ExAC gnomAD
CA384057180 rs1354475114	28	Y>H		No	ClinGen gnomAD
rs751196693 CA6468066	29	G>A		No	ClinGen ExAC gnomAD
rs751196693 CA233634280	29	G>V		No	ClinGen ExAC gnomAD
CA6468067 rs756773642	30	Y>N		No	ClinGen ExAC gnomAD
CA6468068 rs780849482	32	L>*		No	ClinGen ExAC gnomAD
CA384057234 rs1591981383	36	C>G		No	ClinGen Ensembl
CA384057378 rs1222209688	41	P>T		No	ClinGen TOPMed
rs754743986 CA6468098	42	M>L		No	ClinGen ExAC TOPMed gnomAD
CA6468097 rs754743986	42	M>V		No	ClinGen ExAC TOPMed gnomAD
rs200245531 CA384057454	52	I>N		No	ClinGen 1000Genomes ExAC gnomAD
CA6468100 rs200245531	52	I>T		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	53	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1459523849 CA384057480	56	L>W		No	ClinGen gnomAD
rs1196898893 CA384057535	64	G>R		No	ClinGen gnomAD
TCGA novel	64	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6468101 rs777801288	66	T>A		No	ClinGen ExAC gnomAD
CA384057586 rs1189988255	72	T>A		No	ClinGen TOPMed gnomAD
CA6468103 rs529311415	74	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1475314480 CA384057607	75	A>G		No	ClinGen TOPMed gnomAD
rs1221519525 CA384057606	75	A>S		No	ClinGen TOPMed
rs1021401518 CA233634592	79	A>S		No	ClinGen TOPMed
rs1242573212 CA384057679	84	K>N		No	ClinGen TOPMed
rs1288123069 CA384057681	85	V>M		No	ClinGen gnomAD
rs1354702261 CA384057692	86	W>*		No	ClinGen TOPMed
CA233636535 rs947112729	87	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1368326833 CA384057712	89	V>A		No	ClinGen TOPMed
rs377104447 CA233636537	89	V>I		No	ClinGen TOPMed
CA384057709 rs377104447	89	V>L		No	ClinGen TOPMed
rs1258654008 CA384057719	90	S>L		No	ClinGen gnomAD
CA384057726 rs1405478078	92	D>N		No	ClinGen TOPMed
CA233636540 rs150796040	93	E>K		No	ClinGen ESP TOPMed gnomAD
CA6468111 rs760184286	96	T>N		No	ClinGen ExAC gnomAD
CA6468113 rs753742857	98	A>G		No	ClinGen ExAC gnomAD
CA6468112 rs765820617	98	A>P		No	ClinGen ExAC gnomAD
TCGA novel	99	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	104	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1565574389 CA384057820	105	T>S		No	ClinGen Ensembl
rs547715659 CA6468115	109	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs139147519 CA6468131	111	D>G		No	ClinGen 1000Genomes ESP ExAC gnomAD
rs139147519 CA6468132	111	D>V		No	ClinGen 1000Genomes ESP ExAC gnomAD
rs765899633 CA6468130	111	D>Y		No	ClinGen ExAC gnomAD
rs1347216330 CA384057875	112	S>G		No	ClinGen gnomAD
TCGA novel	114	Y>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM107813 rs149620856 CA233636753	115	L>F	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
CA233636755 rs1048672472	117	T>A		No	ClinGen gnomAD
rs1273046185 CA384057914	117	T>S		No	ClinGen TOPMed
TCGA novel	118	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	119	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384057940 rs1359976654	121	D>G		No	ClinGen gnomAD
CA384057951 rs1591985400	122	K>N		No	ClinGen Ensembl
rs999690976 CA384057964	125	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs999690976 CA233636759	125	R>G		No	ClinGen TOPMed gnomAD
rs752651730 CA6468134 COSM172977	125	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1370845176 CA384057973	126	I>M		No	ClinGen gnomAD
CA6468135 rs200103299	126	I>V		No	ClinGen 1000Genomes ExAC TOPMed
rs777545691 CA6468136	127	Y>C		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	127	Y>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384057996 rs1318412644	130	N>H		No	ClinGen gnomAD
rs144953681 CA6468138	130	N>K		No	ClinGen ExAC TOPMed gnomAD
CA384058007 rs1259712097	131	K>R		No	ClinGen gnomAD
CA6468139 rs781313896	132	P>A		No	ClinGen ExAC TOPMed gnomAD
CA6468140 rs745977935	132	P>L		No	ClinGen ExAC gnomAD
CA6468156 rs767598118	137	K>E		No	ClinGen ExAC TOPMed gnomAD
CA384058091 rs1458533168	141	G>V		No	ClinGen TOPMed
CA384058124 rs1260383167	146	I>M		No	ClinGen TOPMed
rs1470408003	149	A>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs780287241 CA6468159	149	A>T		No	ClinGen ExAC gnomAD
CA384058147 rs1197060982 COSM937633	150	L>V	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed
CA6468160 rs749808917	152	C>Y		No	ClinGen ExAC gnomAD
CA384058174 rs1565575759	153	S>R		No	ClinGen Ensembl
CA384058183 rs1476294209	155	D>N		No	ClinGen gnomAD
CA384058186 rs1565575763	155	D>V		No	ClinGen Ensembl
rs755591994 CA384058215	159	L>F		No	ClinGen ExAC TOPMed gnomAD
rs755591994 CA6468161	159	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1230056609 CA384058224	160	S>F		No	ClinGen TOPMed
rs1393846141 CA384058235	162	D>G		No	ClinGen gnomAD
CA233637820 rs149067547	162	D>H		No	ClinGen ESP TOPMed gnomAD
rs1219426417 CA384058261	166	V>L		No	ClinGen gnomAD
rs902903501 CA233637823	167	R>L		No	ClinGen TOPMed gnomAD
rs902903501 CA384058268	167	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA6468181 rs754011605	168	L>V		No	ClinGen ExAC TOPMed gnomAD
CA384058288 rs1257134211	169	W>R		No	ClinGen gnomAD
rs755139045 CA6468182	171	H>L		No	ClinGen ExAC TOPMed gnomAD
rs755139045 CA384058307	171	H>P		No	ClinGen ExAC TOPMed gnomAD
CA6468183 rs779238193	172	A>D		No	ClinGen ExAC gnomAD
rs779238193 CA384058314	172	A>V		No	ClinGen ExAC gnomAD
CA6468184 rs753260309	173	T>A		No	ClinGen ExAC gnomAD
rs531501241 CA6468185	173	T>S		No	ClinGen 1000Genomes ExAC gnomAD
CA384058327 rs1397385547	174	M>I		No	ClinGen gnomAD
CA384058324 rs1166669636	174	M>T		No	ClinGen gnomAD
CA384058321 rs1430192833	174	M>V		No	ClinGen TOPMed
COSM937635 rs1416560685 CA384058337	176	E>*	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA384058347 rs1435755350	177	V>A		No	ClinGen gnomAD
CA6468187 rs745503480	178	K>E		No	ClinGen ExAC gnomAD
rs143256276 CA6468188	178	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA384058367 rs1320966580	181	N>D		No	ClinGen gnomAD
rs146678081 CA6468190	181	N>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA384058383 rs1591987838	183	N>D		No	ClinGen Ensembl
rs140234137 CA233638183	183	N>S		No	ClinGen ESP gnomAD
rs1041121617 CA233638185	187	S>G		No	ClinGen TOPMed
rs1565576163 CA384058411	187	S>T		No	ClinGen Ensembl
CA233638187 rs943324170	189	M>V		No	ClinGen Ensembl
rs761817170 CA6468193	193	P>H		No	ClinGen ExAC gnomAD
rs369553392 COSM692994 CA6468192	193	P>S	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA gnomAD
rs771760502 CA6468194	196	E>G		No	ClinGen ExAC gnomAD
rs773118484 CA6468195	198	L>S		No	ClinGen ExAC
TCGA novel	202	Y>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1285135784 CA384058528	204	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA233638197 rs375544344	205	S>C		No	ClinGen ESP
CA6468197 rs766668044	206	I>V		No	ClinGen ExAC gnomAD
CA6468198 rs754134145	207	A>G		No	ClinGen ExAC gnomAD
rs1421268864 CA384058609	215	D>N		No	ClinGen gnomAD
rs1364054432 CA384058622	216	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA384058617 rs1182952173	216	P>T		No	ClinGen gnomAD
CA384058624 rs1472055918	217	I>F		No	ClinGen gnomAD
rs765215889 CA6468217	219	S>C		No	ClinGen ExAC
CA384058645 rs1200834560	220	F>V		No	ClinGen gnomAD
rs1156391069 CA384058656	221	E>G		No	ClinGen gnomAD
CA384058663 rs1419406234	222	A>G		No	ClinGen gnomAD
CA6468218 rs752866252	225	T>A		No	ClinGen ExAC gnomAD
rs1325173388 CA384058680	225	T>S		No	ClinGen gnomAD
rs1388429251 CA384058693	227	N>I		No	ClinGen TOPMed gnomAD
CA384058701 rs1392972353	228	S>F		No	ClinGen gnomAD
rs1329262950 CA384058719	231	L>P		No	ClinGen gnomAD
CA6468219 rs145164927	232	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA6468220 rs764626491	233	P>L		No	ClinGen ExAC gnomAD
rs1238158252 CA384058758	237	F>L		No	ClinGen TOPMed
rs1264249566 CA384058766	238	L>V		No	ClinGen gnomAD
CA6468225 rs185224819	242	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
TCGA novel	243	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6468226 rs754719468	244	D>V		No	ClinGen ExAC gnomAD
TCGA novel	248	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs531686762 CA6468228	254	S>C		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	255	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	256	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1465717027 CA384058946	261	Y>C		No	ClinGen TOPMed gnomAD
TCGA novel	263	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384058993 rs1167800635	268	I>V		No	ClinGen TOPMed
rs553115575 CA233639486	272	R>S		No	ClinGen 1000Genomes
CA6468245 rs764894800	274	S>G		No	ClinGen ExAC gnomAD
CA384059067 rs1368360222	275	P>A		No	ClinGen TOPMed
CA233639494 rs374693662	276	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
TCGA novel	278	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs374482822 CA233639500	280	Y>C		No	ClinGen ESP
rs1465678599 CA384059133	280	Y>H		No	ClinGen gnomAD
rs1565577504 CA384059179	283	G>V		No	ClinGen Ensembl
CA6468249 rs777491937	298	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1253821180 CA384059379 COSM937640	299	T>M	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
CA384059417 rs1447576787	302	L>F		No	ClinGen gnomAD
TCGA novel	304	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA233639522 rs865946903	307	L>P		No	ClinGen Ensembl
rs867656774 CA233639525	308	P>S		No	ClinGen Ensembl
CA6468267 rs375283378	310	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs756855420 CA6468269	311	D>N		No	ClinGen ExAC gnomAD
rs1228636670 CA384059816	312	S>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1287244999 CA384059838	314	E>K		No	ClinGen gnomAD
CA233639813 rs565040350	320	I>M		No	ClinGen 1000Genomes
rs150448537 CA6468273	320	I>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA233639809 rs1004702555	320	I>V		No	ClinGen TOPMed gnomAD
rs906523286 CA233639815	321	G>V		No	ClinGen Ensembl
rs777706138 CA233639821	322	F>L		No	ClinGen TOPMed gnomAD
rs1219189364 CA384059942	325	T>A		No	ClinGen gnomAD
CA384059944 rs1234380866	325	T>I		No	ClinGen gnomAD
rs768917886 CA6468276	327	E>K		No	ClinGen ExAC gnomAD
rs746834109 CA6468277	329	E>D		No	ClinGen ExAC gnomAD
rs143931116 CA6468303	331	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA384060125 rs1436183128	332	E>G		No	ClinGen gnomAD
CA384060117 rs1340134340	332	E>K		No	ClinGen TOPMed gnomAD
rs1029734714 CA233640407	336	E>A		No	ClinGen TOPMed
TCGA novel	336	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748372811 CA6468305	337	N>T		No	ClinGen ExAC gnomAD
rs772131985 CA6468306	338	S>*		No	ClinGen ExAC gnomAD
rs867398202 CA233640412	338	S>A		No	ClinGen Ensembl
CA384060211 rs1234150249	339	D>G		No	ClinGen gnomAD
CA6468307 rs777773134	340	C>S		No	ClinGen ExAC TOPMed gnomAD
rs777773134 CA384060224	340	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA6468309 rs371184789	342	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	343	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	344	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384060291 rs1474125124	345	A>G		No	ClinGen Ensembl
rs1166953541 CA384060305	347	D>G		No	ClinGen Ensembl
CA384060313 rs1349705233	348	V>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD

No associated diseases with Q9Y3F4

7 regional properties for Q9Y3F4

Type	Name	Position	InterPro Accession
repeat	WD40 repeat	3 - 45	IPR001680-1
repeat	WD40 repeat	48 - 210	IPR001680-2
repeat	WD40 repeat	213 - 251	IPR001680-3
repeat	WD40 repeat	254 - 293	IPR001680-4
repeat	G-protein beta WD-40 repeat	74 - 88	IPR020472-1
repeat	G-protein beta WD-40 repeat	115 - 129	IPR020472-2
repeat	G-protein beta WD-40 repeat	280 - 294	IPR020472-3

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus	Localized predominantly in the cytoplasm but also found in the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
SMN complex	A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus.
SMN-Sm protein complex	A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm.

4 GO annotations of molecular function

Name	Definition
mRNA binding	Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
RNA binding	Binding to an RNA molecule or a portion thereof.
signaling receptor binding	Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
U2 snRNP binding	Binding to a U2 small nuclear ribonucleoprotein particle.

6 GO annotations of biological process

Name	Definition
alternative mRNA splicing, via spliceosome	The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
maintenance of gastrointestinal epithelium	Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
negative regulation of transforming growth factor beta receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
neuron differentiation	The process in which a relatively unspecialized cell acquires specialized features of a neuron.
spliceosomal snRNP assembly	The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9Z1Z2	Strap	Serine-threonine kinase receptor-associated protein	Mus musculus (Mouse)	PR
Q5XIG8	Strap	Serine-threonine kinase receptor-associated protein	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MAMRQTPLTC	SGHTRPVVDL	AFSGITPYGY	FLISACKDGK	PMLRQGDTGD	WIGTFLGHKG
70	80	90	100	110	120
AVWGATLNKD	ATKAATAAAD	FTAKVWDAVS	GDELMTLAHK	HIVKTVDFTQ	DSNYLLTGGQ
130	140	150	160	170	180
DKLLRIYDLN	KPEAEPKEIS	GHTSGIKKAL	WCSEDKQILS	ADDKTVRLWD	HATMTEVKSL
190	200	210	220	230	240
NFNMSVSSME	YIPEGEILVI	TYGRSIAFHS	AVSLDPIKSF	EAPATINSAS	LHPEKEFLVA
250	260	270	280	290	300
GGEDFKLYKY	DYNSGEELES	YKGHFGPIHC	VRFSPDGELY	ASGSEDGTLR	LWQTVVGKTY
310	320	330	340
GLWKCVLPEE	DSGELAKPKI	GFPETTEEEL	EEIASENSDC	IFPSAPDVKA