AiPD: Autoinhibited Protein Database

Q9Y2B0

Gene name	CNPY2 (MSAP, TMEM4, ZSIG9, UNQ1943/PRO4426)
Protein name	Protein canopy homolog 2
Names	MIR-interacting saposin-like protein, Putative secreted protein Zsig9, Transmembrane protein 4
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10330
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

18-92 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

18-92 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9Y2B0

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9Y2B0-F1	Predicted				AlphaFoldDB

139 variants for Q9Y2B0

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs756651654 CA385320292	3	G>R		No	ClinGen ExAC TOPMed gnomAD
CA6629145 rs756651654	3	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1382221513 CA385320245	5	G>D		No	ClinGen TOPMed
rs1389825853 CA385320254	5	G>S		No	ClinGen TOPMed
rs1565629073 CA385320214	6	W>C		No	ClinGen Ensembl
CA6629142 rs758171309	6	W>R		No	ClinGen ExAC gnomAD
CA6629140 rs752507471	8	A>D		No	ClinGen ExAC TOPMed gnomAD
CA237662230 rs1003831638	12	G>R		No	ClinGen Ensembl
rs776375448 CA6629134	16	G>A		No	ClinGen ExAC TOPMed gnomAD
rs776375448 CA385319992	16	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1213382824 CA385320012	16	G>R		No	ClinGen gnomAD
CA385319980 rs1035096291	17	T>I		No	ClinGen TOPMed
CA237662193 rs1035096291	17	T>S		No	ClinGen TOPMed
CA385319967 rs1289892001	18	A>V		No	ClinGen TOPMed gnomAD
CA385319927 rs1269854179	19	W>S		No	ClinGen TOPMed
CA6629133 rs769127255	21	R>W		No	ClinGen ExAC TOPMed gnomAD
CA6629132 rs760669679	23	S>C		No	ClinGen ExAC gnomAD
rs982573219 CA237662183	27	H>L		No	ClinGen TOPMed
CA385319664 rs1199461839	30	A>P		No	ClinGen TOPMed
rs1418889918 CA385319592	31	C>Y		No	ClinGen TOPMed
rs752350174 CA6629118	32	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1383211207 CA385319544	33	A>V		No	ClinGen gnomAD
CA6629117 rs764996007	36	D>A		No	ClinGen ExAC TOPMed gnomAD
CA6629116 rs754753878	37	E>V		No	ClinGen ExAC gnomAD
CA385319456 rs199831088	38	L>V		No	ClinGen 1000Genomes ExAC gnomAD
CA6629114 rs766217104	39	E>V		No	ClinGen ExAC gnomAD
rs574865113 CA6629113	40	W>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs574865113 CA6629112	40	W>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA385319313 rs1357920143	41	E>D		No	ClinGen gnomAD
rs372058833 CA6629111	42	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs527652986 CA237662062	43	A>G		No	ClinGen Ensembl
rs11551983 CA237662059	44	Q>E		No	ClinGen Ensembl
CA385319285 rs1247193114	44	Q>L		No	ClinGen gnomAD
rs79111613 CA6629110	45	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA385319141 rs776150200	49	K>N		No	ClinGen TOPMed
CA385319153 rs774485842	49	K>R		No	ClinGen ExAC TOPMed gnomAD
CA6629109 rs774485842	49	K>T		No	ClinGen ExAC TOPMed gnomAD
rs1393328321 CA385319105	51	I>T		No	ClinGen gnomAD
CA6629108 rs768928573	53	M>V		No	ClinGen ExAC gnomAD
rs1302610360 CA385319002	54	G>E		No	ClinGen gnomAD
TCGA novel	55	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763289877 TCGA novel CA6629107	56	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ExAC gnomAD
rs1363640423 CA385318855	61	D>E		No	ClinGen gnomAD
rs1425104022 CA385318847	62	G>A		No	ClinGen gnomAD
CA385318851 rs1165327609	62	G>S		No	ClinGen TOPMed gnomAD
rs145953285 CA6629076	71	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs867004102 CA237660500	72	A>V		No	ClinGen Ensembl
CA385317913 rs1565627860 COSM3359844	73	R>C	kidney [Cosmic]	No	ClinGen cosmic curated Ensembl
CA6629075 rs747273921	73	R>H		No	ClinGen ExAC gnomAD
TCGA novel	75	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1371859421 CA385317859	77	H>R		No	ClinGen gnomAD
rs904207430 CA237660494	78	L>V		No	ClinGen TOPMed gnomAD
TCGA novel	83	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1202077598 CA385317762	85	I>L		No	ClinGen TOPMed gnomAD
rs1186306496 CA385317751	85	I>M		No	ClinGen TOPMed
rs373723874 CA6629071	86	C>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA385317748 rs373723874	86	C>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA385317729 rs1478469149	87	D>E		No	ClinGen TOPMed
CA6629070 rs566322032	87	D>G		No	ClinGen 1000Genomes ExAC gnomAD
rs751607040 CA6629069	88	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1337475818 CA385317703	90	K>E		No	ClinGen gnomAD
rs1028399502 CA237660487	91	E>V		No	ClinGen TOPMed
CA385317676 rs1592420722	92	Y>D		No	ClinGen Ensembl
CA6629065 rs371411859	95	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs554025526 CA237660428	98	P>L		No	ClinGen 1000Genomes TOPMed
CA6629064 rs190375156	100	T>A		No	ClinGen 1000Genomes ExAC gnomAD
CA385317554 rs1407851903	101	H>R		No	ClinGen gnomAD
rs1450093837 CA385317556	101	H>Y		No	ClinGen gnomAD
rs1004060889 CA237660422	102	R>C		No	ClinGen TOPMed gnomAD
rs886916815 COSM941630 CA237660420	102	R>H	Variant assessed as Somatic; impact. endometrium breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
TCGA novel	106	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1250964493 CA385317492	106	V>I		No	ClinGen gnomAD
rs777195609 CA6629062	107	R>C		No	ClinGen ExAC TOPMed gnomAD
CA6629061 rs766973735	107	R>H		No	ClinGen ExAC gnomAD
TCGA novel	108	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385317448 rs1336911997	110	G>S		No	ClinGen TOPMed
rs748749230 CA6629057	111	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs768166554 CA6629058	111	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1238292211 CA385317419	112	N>I		No	ClinGen gnomAD
TCGA novel	113	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1181312860 CA385317375	116	S>T		No	ClinGen gnomAD
CA6629056 rs775199791	117	E>D		No	ClinGen ExAC gnomAD
rs745649885 CA6629054	118	L>P		No	ClinGen ExAC TOPMed
rs769387294 CA6629055	118	L>V		No	ClinGen ExAC gnomAD
CA385317313 rs1248337852	121	Q>R		No	ClinGen gnomAD
CA6629052 rs757073100	122	G>V		No	ClinGen ExAC gnomAD
CA6629051 rs201509620	123	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6629050 rs777702972	124	R>*		No	ClinGen ExAC gnomAD
CA385317280 rs141635081	124	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs141635081 CA6629049	124	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA385317263 rs76871886	125	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs765486073 CA6629047	126	D>N		No	ClinGen ExAC TOPMed gnomAD
CA6629046 rs755207888	127	S>L		No	ClinGen ExAC gnomAD
CA385317219 rs1433154907	129	I>V		No	ClinGen TOPMed
rs773784477 CA385317188	131	G>C		No	ClinGen ExAC TOPMed gnomAD
rs773784477 CA6629042	131	G>S		No	ClinGen ExAC TOPMed gnomAD
CA385317160 rs1158264150	133	L>P		No	ClinGen gnomAD
CA385317148 rs1468783813	134	K>R		No	ClinGen gnomAD
CA6629040 rs762509546	136	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs370005370 CA6629019	140	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs776200395 CA6629018	144	Y>N		No	ClinGen ExAC gnomAD
rs1228593768 CA385316970	145	E>K		No	ClinGen gnomAD
rs1322283488 CA385316943	146	D>E		No	ClinGen gnomAD
CA385316938 rs1280795687	147	E>K		No	ClinGen gnomAD
rs1467512279 CA385316922	148	L>F		No	ClinGen TOPMed
rs1200649398 CA385316916	148	L>P		No	ClinGen TOPMed
rs760451480 CA6629016	150	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1363961259 CA385316857 COSM256663	151	F>L	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA385316822 rs1270065364	153	S>F		No	ClinGen gnomAD
CA237660236 rs1003924927	154	R>*		No	ClinGen TOPMed gnomAD
CA6629014 rs199561924 COSM310188	154	R>Q	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed
CA385316773 rs1347278521	155	E>G		No	ClinGen gnomAD
rs149635541 CA6629013	156	A>V		No	ClinGen ESP ExAC gnomAD
CA385316754 rs1476043238	157	D>H		No	ClinGen TOPMed
rs1404088144 CA385316729	158	N>D		No	ClinGen gnomAD
rs186850220 CA6629012	158	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs369707938 CA6629011	159	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1425815449 CA385316704	159	V>I		No	ClinGen gnomAD
rs1249642768 CA385316594	163	L>F		No	ClinGen TOPMed gnomAD
CA6629009 rs376827171	167	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA385316482 rs1260785506	168	T>R		No	ClinGen gnomAD
TCGA novel	169	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1233851460 CA385316362	170	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs113524609 CA237660012	172	D>G		No	ClinGen ExAC TOPMed gnomAD
rs113524609 CA6628993	172	D>V		No	ClinGen ExAC TOPMed gnomAD
rs1344943173 CA385316264	174	A>D		No	ClinGen gnomAD
rs756386633 CA6628992	174	A>T		No	ClinGen ExAC TOPMed gnomAD
CA6628991 rs771717574	175	L>P		No	ClinGen ExAC gnomAD
TCGA novel	176	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6628990 rs567326995	177	I>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA385316202 rs1315159407	177	I>M		No	ClinGen gnomAD
CA385316209 rs1357691703	177	I>T		No	ClinGen gnomAD
rs567326995 CA237659996	177	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA237659995 rs904559266	178	S>L		No	ClinGen TOPMed gnomAD
rs774093448 CA6628989	178	S>P		No	ClinGen ExAC gnomAD
rs775749400 CA6628986	180	D>G		No	ClinGen ExAC gnomAD
CA6628987 rs144428833	180	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA385316110 rs770022738	181	E>D		No	ClinGen ExAC TOPMed gnomAD
CA237659975 rs1026841310	181	E>K		No	ClinGen TOPMed gnomAD

No associated diseases with Q9Y2B0

2 regional properties for Q9Y2B0

Type	Name	Position	InterPro Accession
domain	Saposin B type domain	24 - 175	IPR008139
domain	Domain of unknown function DUF3456	27 - 171	IPR021852

Functions

		Description
EC Number
Subcellular Localization	Endoplasmic reticulum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name	Definition
negative regulation of gene expression	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of low-density lipoprotein receptor activity	Any process that activates or increases the frequency, rate or extent of low-density lipoprotein receptor activity.
regulation of low-density lipoprotein particle clearance	Any process that modulates the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2L6L1	cnpy1	Protein canopy-1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MKGWGWLALL	LGALLGTAWA	RRSQDLHCGA	CRALVDELEW	EIAQVDPKKT	IQMGSFRINP
70	80	90	100	110	120
DGSQSVVEVP	YARSEAHLTE	LLEEICDRMK	EYGEQIDPST	HRKNYVRVVG	RNGESSELDL
130	140	150	160	170	180
QGIRIDSDIS	GTLKFACESI	VEEYEDELIE	FFSREADNVK	DKLCSKRTDL	CDHALHISHD

EL