AiPD: Autoinhibited Protein Database

Gene name	ALG11 (LEW3, At2g40190, T07M07.7)
Protein name	GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
Names	Alpha-1,2-mannosyltransferase ALG11, Asparagine-linked glycosylation protein 11, Protein LEAF WILTING 3
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT2G40190
EC number	2.4.1.131: Hexosyltransferases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

229-347 (Predicted disordered autoinhibitory region) PR

229-347 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9XEE9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_2_16785248_T_G	6	I>S	No	1000Genomes
ENSVATH05689350	18	S>T	No	1000Genomes
ENSVATH05689351	20	S>T	No	1000Genomes
tmp_2_16785299_T_A	23	L>H	No	1000Genomes
ENSVATH14601058	28	A>V	No	1000Genomes
ENSVATH05689352	29	R>K	No	1000Genomes
tmp_2_16785407_C_T	59	A>V	No	1000Genomes
ENSVATH00267086	70	V>A	No	1000Genomes
tmp_2_16785496_G_A	89	D>N	No	1000Genomes
ENSVATH13592972	131	A>V	No	1000Genomes
tmp_2_16785797_T_C	138	F>L	No	1000Genomes
tmp_2_16785927_G_A	181	R>H	No	1000Genomes
tmp_2_16785939_C_T	185	S>F	No	1000Genomes
ENSVATH05689361	191	A>S	No	1000Genomes
ENSVATH14601062	246	T>S	No	1000Genomes
ENSVATH05689367	247	R>L	No	1000Genomes
ENSVATH05689372	315	N>K	No	1000Genomes
tmp_2_16786651_A_C	323	K>N	No	1000Genomes
tmp_2_16786670_G_A	330	E>K	No	1000Genomes
tmp_2_16786694_C_G	338	Q>E	No	1000Genomes
tmp_2_16786841_G_A	356	V>I	No	1000Genomes
ENSVATH13592985	357	A>V	No	1000Genomes
ENSVATH13592987	396	E>K	No	1000Genomes
tmp_2_16787059_C_T,G	398	D>E	No	1000Genomes
tmp_2_16787090_G_C	409	V>L	No	1000Genomes
ENSVATH00267090	410	E>V	No	1000Genomes
ENSVATH13592988	452	T>I	No	1000Genomes
ENSVATH13592988	452	T>N	No	1000Genomes
ENSVATH05689374	453	A>S	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Glycosyl transferase, family 1	261 - 437	IPR001296
domain	ALG11 mannosyltransferase, N-terminal	34 - 239	IPR031814

		Description
EC Number	2.4.1.131	Hexosyltransferases
Subcellular Localization	Endoplasmic reticulum membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

Name	Definition
GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity	Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.

Name	Definition
oligosaccharide-lipid intermediate biosynthetic process	The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation.
plant-type cell wall biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellulose and pectin-containing cell wall. An example of this is found in Arabidopsis thaliana.
protein N-linked glycosylation	A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan.
response to abscisic acid	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
response to osmotic stress	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P53954	ALG11	GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q6P312	alg11	GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q7ZW24	alg11	GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase	Danio rerio (Zebrafish) (Brachydanio rerio)	PR