Q7ZW24

PR
Gene name
alg11
Protein name
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
Names
Asparagine-linked glycosylation protein 11 homolog, Glycolipid 2-alpha-mannosyltransferase
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
EC number
2.4.1.131: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

18-89 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7ZW24

Entry ID Method Resolution Chain Position Source
AF-Q7ZW24-F1 Predicted AlphaFoldDB

No variants for Q7ZW24

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7ZW24

No associated diseases with Q7ZW24

2 regional properties for Q7ZW24

Type Name Position InterPro Accession
domain Zinc finger, RING-type 375 - 413 IPR001841
conserved_site Zinc finger, RING-type, conserved site 390 - 399 IPR017907

Functions

Description
EC Number 2.4.1.131 Hexosyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

1 GO annotations of molecular function

Name Definition
GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.

2 GO annotations of biological process

Name Definition
oligosaccharide-lipid intermediate biosynthetic process The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation.
protein N-linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P53954 ALG11 GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9XEE9 ALG11 GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase Arabidopsis thaliana (Mouse-ear cress) PR
Q6P312 alg11 GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MSAHDHFSLC LCDLIRLLWS LMLPCFYLSF LLTTILFLFI MGVRSWLQMK RKTRRVQDGR
70 80 90 100 110 120
PAVAFFHPYC NAGGGGERVL WCALRALQNR YQDVSFVVYT GDQGVTAEEI LDGARRRFNI
130 140 150 160 170 180
RLPRPVKFVF LKHRLLVEAK LYPHFTLLGQ SVGSIFLGWE ALTEFVPDLY IDSMGFAFTL
190 200 210 220 230 240
PVFRYLGGCQ VGSYVHYPTI STDMLSVVRE RNPRFNNADY ISSNPVLSAI KVIYYCVFAL
250 260 270 280 290 300
LYGLAGSCSD VIMVNSTWTL GHILALWRTP NRTSVVYPPC DVQAFLDVPI GEDNEEKEQK
310 320 330 340 350 360
KCHSLVSVGQ FRPEKDHQLQ IRAFKKLLDR KEAEPAGREA VKLVLIGGCR NQEDEDRVLM
370 380 390 400 410 420
LRGLCQELGI ADRVEFKLNI PFQELKKDLT DATIGLHTMW NEHFGIGIVE CMAAGTIILA
430 440 450 460 470 480
HKSGGPKLDI VVPYDGGPTG FLADDEDNYA DAMERILSMS PATRLEMRRR ARLSVSRFSD
490
QEFEGSFLSA MEPLMSTLRA