Q9WVM8

PR
Gene name
Aadat
Protein name
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Names
KAT/AadAT, 2-aminoadipate aminotransferase, 2-aminoadipate transaminase, Alpha-aminoadipate aminotransferase, AadAT, Glycine transaminase AADAT, Kynurenine aminotransferase II, Kynurenine--glyoxylate transaminase AADAT, Kynurenine--oxoglutarate aminotransferase II, Kynurenine--oxoglutarate transaminase 2, Kynurenine--oxoglutarate transaminase II, Methionine--glyoxylate transaminase AADAT
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:23923
EC number
2.6.1.4: Transaminases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-71 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9WVM8

Entry ID Method Resolution Chain Position Source
AF-Q9WVM8-F1 Predicted AlphaFoldDB

23 variants for Q9WVM8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388976867 14 R>K No EVA
rs3388970535 30 P>S No EVA
rs3388970540 43 P>S No EVA
rs3388985306 55 V>M No EVA
rs3388988580 61 I>F No EVA
rs246870606 67 L>V No EVA
rs213104401 76 P>S No EVA
rs3388981334 80 I>N No EVA
rs3388988507 189 K>R No EVA
rs3388988547 224 D>E No EVA
rs3388960782 230 D>E No EVA
rs3388966381 234 Y>* No EVA
rs3388985325 262 S>P No EVA
rs232130553 265 V>I No EVA
rs218072014 279 T>P No EVA
rs3399150256 294 H>Q No EVA
rs3388985034 318 H>R No EVA
rs36719922 327 K>R No EVA
rs3388982654 347 W>G No EVA
rs232045338 391 G>D No EVA
rs216356203 393 A>T No EVA
rs3388982239 399 R>K No EVA
rs3388987615 403 S>T No EVA

No associated diseases with Q9WVM8

1 regional properties for Q9WVM8

Type Name Position InterPro Accession
domain Aminotransferase, class I/classII 71 - 417 IPR004839

Functions

Description
EC Number 2.6.1.4 Transaminases
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

8 GO annotations of molecular function

Name Definition
2-aminoadipate transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate.
glycine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate.
kynurenine-glyoxylate transaminase activity Catalysis of the reaction: L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine.
kynurenine-oxoglutarate transaminase activity Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
methionine-glyoxylate transaminase activity Catalysis of the reaction: L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine.
protein homodimerization activity Binding to an identical protein to form a homodimer.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
transaminase activity Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.

6 GO annotations of biological process

Name Definition
2-oxoglutarate metabolic process The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
alpha-amino acid metabolic process The chemical reactions and pathways involving an alpha-amino acid.
biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
glutamate metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.
kynurenine metabolic process The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine.
L-lysine catabolic process to acetyl-CoA via saccharopine The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate saccharopine.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5E9N4 AADAT Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Bos taurus (Bovine) PR
Q8N5Z0 AADAT Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Homo sapiens (Human) PR
10 20 30 40 50 60
MNYSRFLTAT SLARKPSPIR TTADILSKAP KTLISLAPGS PNPSMFPFKS AAFTVENGST
70 80 90 100 110 120
IRFEDDLIKR ALQYSPSYGI PELLSWLKQF QVKLHNPPTV NYPPNQGQMD LCITSGCQDG
130 140 150 160 170 180
LCKAFEMLIN PGDTILVNEP LFPGTLYAMK PLGCNIINVP SDEHGIIPEG LKKILSQWKP
190 200 210 220 230 240
EDSKDPTKKT PKFLYTVPNG NNPTGNSLTG DRKKEIYELA RKYDFLIIED DPYYFLQFSK
250 260 270 280 290 300
PWEPTFLSMD VDGRVIRADT FSKTVSSGLR VGFMTGPKTL IQNIVLHTQV SSVHACTLSQ
310 320 330 340 350 360
LMILQLLHQW GEEGFLAHID RTIDFYKNQR DSILAAADKW LRGLAEWHVP KAGMFLWIKV
370 380 390 400 410 420
KGISDTKQLI EEKAIEREVL LVPGNGFFID GSAPTSFFRA SFSLATPAQM DTAFQRLAQL
IKESL