AiPD: Autoinhibited Protein Database

Q8N5Z0

Gene name	AADAT
Protein name	Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Names	KAT/AadAT, 2-aminoadipate aminotransferase, 2-aminoadipate transaminase, Alpha-aminoadipate aminotransferase, AadAT, Glycine transaminase AADAT, Kynurenine aminotransferase II, Kynurenine--glyoxylate transaminase AADAT, Kynurenine--oxoglutarate aminotransferase II, Kynurenine--oxoglutarate transaminase 2, Kynurenine--oxoglutarate transaminase II, Methionine--glyoxylate transaminase AADAT
Species	Homo sapiens (Human)
KEGG Pathway	hsa:51166
EC number	2.6.1.4: Transaminases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-60 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

18 structures for Q8N5Z0

Entry ID	Method	Resolution	Chain	Position	Source
2QLR	X-ray	230 A	A/B/C/D	1-425	PDB
2R2N	X-ray	195 A	A/B/C/D	1-425	PDB
2VGZ	X-ray	230 A	A/B	2-425	PDB
2XH1	X-ray	210 A	A/B	1-425	PDB
3DC1	X-ray	250 A	A/B/C/D	1-425	PDB
3UE8	X-ray	322 A	A/B	1-425	PDB
4GDY	X-ray	289 A	A/B	1-425	PDB
4GE4	X-ray	241 A	A/B	1-425	PDB
4GE7	X-ray	210 A	A/B	1-425	PDB
4GE9	X-ray	243 A	A/B/C/D	1-425	PDB
4GEB	X-ray	215 A	A/B	1-425	PDB
5EFS	X-ray	183 A	A	1-425	PDB
5EUN	X-ray	182 A	A	1-425	PDB
5TF5	X-ray	181 A	A/B	1-425	PDB
6D0A	X-ray	147 A	A	1-425	PDB
6T8P	X-ray	202 A	A/B	1-425	PDB
6T8Q	X-ray	251 A	A	1-425	PDB
AF-Q8N5Z0-F1	Predicted				AlphaFoldDB

221 variants for Q8N5Z0

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA358757759 rs1425816123	4	A>G		No	ClinGen gnomAD
rs1467125404 CA358757763	4	A>T		No	ClinGen gnomAD
rs1191628150 CA358757756	5	R>W		No	ClinGen gnomAD
CA109985205 rs1017430781	9	A>T		No	ClinGen TOPMed gnomAD
CA109985204 rs1040775617	11	S>N		No	ClinGen gnomAD
CA3139642 rs751685780	12	A>T		No	ClinGen ExAC gnomAD
rs1199772636 CA358757682	16	P>L		No	ClinGen gnomAD
rs1320649412 CA358757677	17	S>C		No	ClinGen gnomAD
CA358757676 rs1320649412	17	S>F		No	ClinGen gnomAD
rs1255576778 CA358757661	20	R>W		No	ClinGen TOPMed gnomAD
rs1217522047 CA358757645	22	M>I		No	ClinGen gnomAD
rs766029947 CA3139614	24	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1482445104 CA358757222	25	I>V		No	ClinGen gnomAD
CA109984977 rs768749259	27	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1339110095 CA358757178	28	R>K		No	ClinGen TOPMed
rs1265427621 CA358757164	29	G>E		No	ClinGen gnomAD
CA3139610 rs761367463	33	M>I		No	ClinGen ExAC gnomAD
CA3139609 rs777046313	35	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA358757052 rs1490727321	37	A>S		No	ClinGen TOPMed
CA3139608 rs769204528	38	G>S		No	ClinGen ExAC gnomAD
CA109984971 rs930770122	39	G>D		No	ClinGen Ensembl
rs973609669 CA109984970	41	P>Q		No	ClinGen Ensembl
CA358756993 rs1209123754	42	N>S		No	ClinGen gnomAD
rs747437640 CA3139607	45	M>T		No	ClinGen ExAC gnomAD
CA358756916 rs1220589433	47	P>R		No	ClinGen gnomAD
CA3139604 rs746038548	52	V>A		No	ClinGen ExAC TOPMed gnomAD
CA3139605 rs772428576	52	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	54	T>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA109984965 rs921999105	54	T>S		No	ClinGen TOPMed gnomAD
rs1242683262 CA358756857	55	V>A		No	ClinGen TOPMed
rs1322027631 CA358756851	56	E>G		No	ClinGen gnomAD
CA358756843 rs1448811842	57	N>S		No	ClinGen TOPMed
CA358756827 rs1401709165	59	K>N		No	ClinGen TOPMed gnomAD
rs1440757922 CA358756829	59	K>R		No	ClinGen gnomAD
rs1172181698 CA358756824	60	T>A		No	ClinGen gnomAD
rs1386862575 CA358756813	61	I>M		No	ClinGen TOPMed
rs201523439 CA3139603	62	Q>K		No	ClinGen 1000Genomes ExAC gnomAD
CA109984964 rs974776383	62	Q>R		No	ClinGen Ensembl
CA3139602 rs757318974	63	F>S		No	ClinGen ExAC gnomAD
rs200677642 CA3139601	66	E>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA109984963 rs372381527	67	M>L		No	ClinGen Ensembl
TCGA novel	71	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751355240 CA3139598	76	P>L		No	ClinGen ExAC gnomAD
rs762619514 CA3139596	78	A>P		No	ClinGen ExAC gnomAD
CA358756580 rs1456458045	79	G>A		No	ClinGen gnomAD
TCGA novel	80	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358756420 rs1200059484	83	L>P		No	ClinGen TOPMed
CA358756406 rs1362163974	85	S>F		No	ClinGen gnomAD
CA358756381 rs1254397449	89	Q>*		No	ClinGen TOPMed
rs1367388200 CA358756377	89	Q>H		No	ClinGen TOPMed gnomAD
CA358756374 rs1187409797	90	L>V		No	ClinGen gnomAD
rs373520837 CA109984757	95	H>R		No	ClinGen Ensembl
CA358756318 rs1184561713	97	P>L		No	ClinGen gnomAD
rs1581598831 CA358756311	99	T>P		No	ClinGen Ensembl
rs763621026 CA3139567	102	Y>C		No	ClinGen ExAC gnomAD
rs17852900 CA358756269	103	P>L		No	ClinGen gnomAD
rs17852900 CA109984755	103	P>Q		No	ClinGen gnomAD
CA358756280 rs1581598818	103	P>T		No	ClinGen Ensembl
rs1471887450 CA358756239	106	Q>K		No	ClinGen TOPMed
rs1182519128 CA358756220	107	G>R		No	ClinGen TOPMed gnomAD
CA3139565 rs565975733	109	M>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	111	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358756131 rs1373200177	112	C>R		No	ClinGen TOPMed
CA358756121 rs1187434478	112	C>S		No	ClinGen gnomAD
rs774717219 CA3139562	114	T>I		No	ClinGen ExAC gnomAD
rs1256387233 CA358756058	115	S>C		No	ClinGen gnomAD
CA358756005 rs368592471	118	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA358755932 rs1389603283	123	K>R		No	ClinGen TOPMed
rs748288798 CA3139538	126	E>Q		No	ClinGen ExAC gnomAD
rs776636092 CA358753570 CA3139537	127	M>I		No	ClinGen ExAC TOPMed gnomAD
rs772003106 CA3139536	129	I>T		No	ClinGen ExAC gnomAD
COSM1053212 CA358753528 rs1561020255	130	N>D	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA358753428 rs1164845687	135	V>A		No	ClinGen TOPMed gnomAD
rs1439397784 CA358753377	138	D>E		No	ClinGen TOPMed gnomAD
TCGA novel	142	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358753309 rs1368167584	147	Q>R		No	ClinGen TOPMed
rs1394874229 CA358752061	150	H>Y		No	ClinGen gnomAD
CA109980469 rs778929860	151	P>S		No	ClinGen Ensembl
CA358752020 rs1475000767	156	I>T		No	ClinGen TOPMed
CA3139511 rs747749864	156	I>V		No	ClinGen ExAC TOPMed gnomAD
CA3139510 rs780966008	160	A>T		No	ClinGen ExAC gnomAD
TCGA novel	160	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3139509 rs754560049	161	S>N		No	ClinGen ExAC gnomAD
rs751031083 CA3139508	163	E>G		No	ClinGen ExAC gnomAD
TCGA novel	163	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358751940 rs1257462322	168	P>S		No	ClinGen gnomAD
CA358751932 rs1208284368	169	D>A		No	ClinGen gnomAD
rs750792452 CA3139505	172	R>*		No	ClinGen ExAC gnomAD
rs267600079 CA109980441	172	R>K		No	ClinGen gnomAD
rs267600079 CA358751916	172	R>T		No	ClinGen gnomAD
rs1390948545 CA358751898	174	I>M		No	ClinGen gnomAD
rs1304930129 CA358751900	174	I>T		No	ClinGen gnomAD
rs765548846 CA3139504	177	R>I		No	ClinGen ExAC gnomAD
rs765548846 CA358751883	177	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA3139503 rs762045577	178	W>L		No	ClinGen ExAC
CA358751843 rs1304752701	182	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs754110103 CA3139502	186	P>H		No	ClinGen ExAC TOPMed gnomAD
rs754110103 CA358751815	186	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA358751798 rs1375181883	187	Q>H		No	ClinGen gnomAD
CA358751806 rs1239347023	187	Q>R		No	ClinGen gnomAD
rs764216489 CA3139501	189	N>D		No	ClinGen ExAC TOPMed gnomAD
rs1010300173 CA109980409	189	N>I		No	ClinGen Ensembl
CA358751764 rs1362627395 COSM1539899	190	T>A	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA109980402 rs891439256 COSM1695258	192	K>R	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
rs775374457 CA3139499	193	F>C		No	ClinGen ExAC gnomAD
rs1162961104 CA358751715	194	L>I		No	ClinGen TOPMed
rs1257675827 CA358751693	195	Y>C		No	ClinGen TOPMed gnomAD
CA358751604 rs1485157498	199	N>D		No	ClinGen gnomAD
CA3139496 rs773158625	210	S>G		No	ClinGen ExAC gnomAD
rs1052188225 CA358751361	211	E>D		No	ClinGen TOPMed gnomAD
rs1295236919 CA358751354	212	R>C		No	ClinGen gnomAD
rs1355118438 CA358751325	214	K>E		No	ClinGen TOPMed gnomAD
CA358751248 rs1402318441	217	Y>C		No	ClinGen gnomAD
rs1453241692 CA358750270	220	A>V		No	ClinGen gnomAD
CA358749989 rs1212996721	222	K>R		No	ClinGen gnomAD
TCGA novel	223	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	225	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358749918 rs1581576448	228	I>K		No	ClinGen Ensembl
rs773320216 CA358749919	228	I>L		No	ClinGen ExAC TOPMed gnomAD
rs773320216 CA3139473	228	I>V		No	ClinGen ExAC TOPMed gnomAD
CA358749904 rs1269735608	230	D>N		No	ClinGen gnomAD
TCGA novel	232	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358749886 rs1170592122	232	P>R		No	ClinGen TOPMed
CA358749888 rs1216507753	232	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA358749884 rs1337738611	233	Y>N		No	ClinGen gnomAD
rs545729940 CA109979202	234	Y>C		No	ClinGen gnomAD
CA3139471 rs776235647	237	Q>H		No	ClinGen ExAC gnomAD
CA3139469 rs557457280	239	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3139468 rs377049488	240	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs56350236 CA3139453 VAR_061005	243	V>I		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA3139452 rs753702003	245	T>R		No	ClinGen ExAC gnomAD
rs1172823661 CA358749762	249	M>V		No	ClinGen gnomAD
rs1420207635 CA358749742	251	V>A		No	ClinGen gnomAD
CA358749723 rs1272660297	254	R>H		No	ClinGen gnomAD
rs1272660297 CA358749722	254	R>L		No	ClinGen gnomAD
rs763749090 CA3139451	254	R>S		No	ClinGen ExAC gnomAD
CA358749721 rs1260243523	255	V>I		No	ClinGen TOPMed
CA358749698 rs1179017809	258	A>D		No	ClinGen gnomAD
rs1581574546 CA358749667	263	K>Q		No	ClinGen Ensembl
rs1561013778 CA358749649	265	I>T		No	ClinGen Ensembl
rs760496804 CA3139450	265	I>V		No	ClinGen ExAC TOPMed gnomAD
CA358749597 rs1429916730	271	I>M		No	ClinGen gnomAD
rs1350460338 CA358749594	272	G>R		No	ClinGen gnomAD
rs1326662965 CA358749565	276	G>D		No	ClinGen gnomAD
TCGA novel	277	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	282	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773871959 CA3139427	283	R>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1487212742 CA358749516 CA358749517	283	R>S		No	ClinGen TOPMed
rs151231482 CA109978429	284	V>I		No	ClinGen ESP
TCGA novel	285	I>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3139425 rs770474107	285	I>S		No	ClinGen ExAC gnomAD
CA109978423 rs1030363229	286	L>F		No	ClinGen Ensembl
rs762489440 CA3139424	287	H>D		No	ClinGen ExAC gnomAD
rs773656274 CA3139423	288	I>M		No	ClinGen ExAC TOPMed gnomAD
CA3139421 rs748477745	291	S>L		No	ClinGen ExAC gnomAD
rs781637765 CA3139420	294	H>L		No	ClinGen ExAC gnomAD
rs1198839695 CA358749365	299	N>D		No	ClinGen gnomAD
rs1581573616 CA358749355	299	N>K		No	ClinGen Ensembl
rs780401971 CA3139417	299	N>S		No	ClinGen ExAC TOPMed gnomAD
CA358749344 rs1293166075	300	Q>R		No	ClinGen TOPMed gnomAD
CA3139393 rs368676033	303	I>L		No	ClinGen ESP ExAC gnomAD
CA358749217 rs1247831886	303	I>M		No	ClinGen TOPMed gnomAD
CA358749232 rs368676033	303	I>V		No	ClinGen ESP ExAC gnomAD
rs142229838 CA3139392	304	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA358749139 rs779009351	308	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs1581571680 CA358749149	308	H>Y		No	ClinGen Ensembl
rs368304372 CA3139389	309	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs748131877 CA3139388	310	W>R		No	ClinGen ExAC TOPMed gnomAD
rs992651734 CA109977913	318	H>Y		No	ClinGen TOPMed
CA358748966 rs1561012545	319	V>I		No	ClinGen Ensembl
rs781071963 CA3139387	320	D>G		No	ClinGen ExAC gnomAD
CA358748955 rs1261169161	320	D>N		No	ClinGen gnomAD
rs754830422 CA3139386	321	R>K		No	ClinGen ExAC gnomAD
rs754848971 CA3139367	322	V>I		No	ClinGen ExAC gnomAD
rs545144600 CA3139366	323	I>T		No	ClinGen 1000Genomes ExAC gnomAD
CA3139365 rs779862124	325	F>I		No	ClinGen ExAC gnomAD
TCGA novel	325	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3139364 rs369026657	326	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs116082202 CA3139363	327	S>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs921398428 CA109977552	331	D>N		No	ClinGen TOPMed gnomAD
CA358747291 rs1366770056	338	D>E		No	ClinGen TOPMed
rs147615281 CA3139360	342	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1455567118 CA358746806	347	W>R		No	ClinGen gnomAD
rs145190544 CA3139340	348	H>R		No	ClinGen ESP ExAC gnomAD
rs1191892782 CA358746757	349	V>D		No	ClinGen gnomAD
TCGA novel	356	L>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1290781761 CA358746383	365	D>N		No	ClinGen TOPMed
rs374628121 CA3139337	366	V>I		No	ClinGen ESP ExAC gnomAD
CA358746197 rs1337799234	370	I>T		No	ClinGen gnomAD
CA3139336 rs751810308	372	E>G		No	ClinGen ExAC gnomAD
CA358746101 rs1235619186	374	A>T		No	ClinGen gnomAD
rs766590826 CA3139335	374	A>V		No	ClinGen ExAC TOPMed gnomAD
CA109976947 rs755665287	375	V>A		No	ClinGen Ensembl
CA358746069 rs200099784	375	V>F		No	ClinGen ExAC TOPMed gnomAD
rs200099784 CA3139332	375	V>I		No	ClinGen ExAC TOPMed gnomAD
CA358746028 rs1292066664	376	K>N		No	ClinGen TOPMed
rs1490064762 CA358746020	377	M>L		No	ClinGen TOPMed
rs1561010805 CA358746014	377	M>T		No	ClinGen Ensembl
CA358745961 rs1356225307	378	G>E		No	ClinGen gnomAD
rs1160415427 CA358744624	379	V>L		No	ClinGen gnomAD
TCGA novel	380	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1471723874 CA358744601	380	L>S		No	ClinGen gnomAD
CA3139314 CA3139315 rs765444553	381	M>L		No	ClinGen ExAC gnomAD
rs762011420 CA3139313	382	L>F		No	ClinGen ExAC gnomAD
rs1446118862 CA358744528	383	P>L		No	ClinGen TOPMed
rs1446118862 CA358744526	383	P>R		No	ClinGen TOPMed
rs1486831747 CA358744490	385	N>S		No	ClinGen gnomAD
CA358744429 rs1255889934	388	Y>H		No	ClinGen gnomAD
CA3139311 rs767495658	389	V>I		No	ClinGen ExAC TOPMed gnomAD
CA3139310 rs139598358	390	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs376931614 CA3139309	391	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA358744359 rs1293468526	392	S>T		No	ClinGen gnomAD
rs1234770102 CA358744300	395	S>C		No	ClinGen gnomAD
CA358744239 rs1283419238	397	Y>C		No	ClinGen gnomAD
rs1455646499 CA358744048	404	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA358743858 rs1388012625	411	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA3139304 rs780525079	412	V>L		No	ClinGen ExAC gnomAD
CA3139303 rs780525079	412	V>M		No	ClinGen ExAC gnomAD
rs1220181330 CA358743650	415	Q>E		No	ClinGen gnomAD
CA358743634 rs1487298471	416	V>I		No	ClinGen TOPMed gnomAD
CA358743552 rs1302880252	421	I>V		No	ClinGen TOPMed

No associated diseases with Q8N5Z0

1 regional properties for Q8N5Z0

Type	Name	Position	InterPro Accession
domain	Aminotransferase, class I/classII	59 - 415	IPR004839

Functions

		Description
EC Number	2.6.1.4	Transaminases
Subcellular Localization	Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
mitochondrial matrix	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

8 GO annotations of molecular function

Name	Definition
2-aminoadipate transaminase activity	Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate.
glycine:2-oxoglutarate aminotransferase activity	Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate.
kynurenine-glyoxylate transaminase activity	Catalysis of the reaction: L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine.
kynurenine-oxoglutarate transaminase activity	Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
methionine-glyoxylate transaminase activity	Catalysis of the reaction: L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
pyridoxal phosphate binding	Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
transaminase activity	Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.

6 GO annotations of biological process

Name	Definition
2-oxoglutarate metabolic process	The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
alpha-amino acid metabolic process	The chemical reactions and pathways involving an alpha-amino acid.
biosynthetic process	The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
glutamate metabolic process	The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.
kynurenine metabolic process	The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine.
L-lysine catabolic process to acetyl-CoA via saccharopine	The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate saccharopine.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5E9N4	AADAT	Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Bos taurus (Bovine)	PR
Q9WVM8	Aadat	Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MNYARFITAA	SAARNPSPIR	TMTDILSRGP	KSMISLAGGL	PNPNMFPFKT	AVITVENGKT
70	80	90	100	110	120
IQFGEEMMKR	ALQYSPSAGI	PELLSWLKQL	QIKLHNPPTI	HYPPSQGQMD	LCVTSGSQQG
130	140	150	160	170	180
LCKVFEMIIN	PGDNVLLDEP	AYSGTLQSLH	PLGCNIINVA	SDESGIVPDS	LRDILSRWKP
190	200	210	220	230	240
EDAKNPQKNT	PKFLYTVPNG	NNPTGNSLTS	ERKKEIYELA	RKYDFLIIED	DPYYFLQFNK
250	260	270	280	290	300
FRVPTFLSMD	VDGRVIRADS	FSKIISSGLR	IGFLTGPKPL	IERVILHIQV	STLHPSTFNQ
310	320	330	340	350	360
LMISQLLHEW	GEEGFMAHVD	RVIDFYSNQK	DAILAAADKW	LTGLAEWHVP	AAGMFLWIKV
370	380	390	400	410	420
KGINDVKELI	EEKAVKMGVL	MLPGNAFYVD	SSAPSPYLRA	SFSSASPEQM	DVAFQVLAQL

IKESL