Q9WTL4
SS
Gene name |
Insrr (Irr) |
Protein name |
Insulin receptor-related protein |
Names |
IRR , EC 2.7.10.1 , IR-related receptor [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain] |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:23920 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
Insulin-like growth factor 1 receptor(IGF-I receptor). The JM(juxtamembrane) region of the human insulin-like growth factor I receptor (IGF1R) plays a role in kinase regulation. The JM region is involved in regulating IGF1R activity by inhibiting the autophosphorylation activity of the kinase. The JM region of IGF1R also plays an important role in limiting the basal activity of the receptor.
Autoinhibitory domains (AIDs)
Target domain |
979-1254 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Target domain |
979-1254 (FnIII-2 domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
1132-1157 (Activation loop from InterPro)
Target domain |
979-1254 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Craddock BP et al. (2007) "Autoinhibition of the insulin-like growth factor I receptor by the juxtamembrane region", FEBS letters, 581, 3235-40
- Uchikawa E et al. (2019) "Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex", eLife, 8,
- Nielsen J et al. (2022) "Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling", Journal of molecular biology, 434, 167458
- Chen YS et al. (2021) "Insertion of a synthetic switch into insulin provides metabolite-dependent regulation of hormone-receptor activation", Proceedings of the National Academy of Sciences of the United States of America, 118,
- Huang X et al. (2009) "Structural insights into the inhibited states of the Mer receptor tyrosine kinase", Journal of structural biology, 165, 88-96
- Hubbard SR (2004) "Juxtamembrane autoinhibition in receptor tyrosine kinases", Nature reviews. Molecular cell biology, 5, 464-71
- Hubbard SR et al. (1994) "Crystal structure of the tyrosine kinase domain of the human insulin receptor", Nature, 372, 746-54
Autoinhibited structure
Activated structure
1 structures for Q9WTL4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9WTL4-F1 | Predicted | AlphaFoldDB |
65 variants for Q9WTL4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388633777 | 10 | G>E | No | EVA | |
| rs3388639062 | 18 | L>V | No | EVA | |
| rs3388631166 | 25 | D>N | No | EVA | |
| rs3388632486 | 37 | S>L | No | EVA | |
| rs3388626968 | 38 | E>D | No | EVA | |
| rs3388636242 | 51 | V>M | No | EVA | |
| rs3388639034 | 58 | L>I | No | EVA | |
| rs3388642034 | 84 | L>P | No | EVA | |
| rs3388638871 | 119 | E>D | No | EVA | |
| rs214889954 | 126 | V>I | No | EVA | |
| rs3388638850 | 127 | G>R | No | EVA | |
| rs3388633893 | 133 | A>T | No | EVA | |
| rs3393196782 | 140 | R>QR* | No | EVA | |
| rs3388633937 | 162 | P>L | No | EVA | |
| rs253495245 | 220 | M>L | No | EVA | |
| rs3393363706 | 223 | T>R | No | EVA | |
| rs3393246088 | 224 | A>C* | No | EVA | |
| rs1131886395 | 225 | G>S | No | EVA | |
| rs3393363758 | 239 | Q>H | No | EVA | |
| rs3388636284 | 246 | C>R | No | EVA | |
| rs1134942518 | 276 | T>A | No | EVA | |
| rs3410463654 | 300 | C>* | No | EVA | |
| rs3388639626 | 305 | P>T | No | EVA | |
| rs3388638799 | 307 | G>A | No | EVA | |
| rs3393304843 | 311 | N>CG* | No | EVA | |
| rs3393354880 | 311 | N>H | No | EVA | |
| rs253997961 | 313 | S>R | No | EVA | |
| rs3388638832 | 328 | C>S | No | EVA | |
| rs3388632407 | 340 | A>T | No | EVA | |
| rs3388628470 | 370 | R>G | No | EVA | |
| rs3388636327 | 379 | T>I | No | EVA | |
| rs3388619400 | 459 | V>M | No | EVA | |
| rs1134214398 | 468 | K>* | No | EVA | |
| rs3388631195 | 500 | L>P | No | EVA | |
| rs3388639653 | 504 | E>D | No | EVA | |
| rs3388641136 | 547 | D>V | No | EVA | |
| rs3388642023 | 556 | Q>H | No | EVA | |
| rs3388639597 | 643 | Q>E | No | EVA | |
| rs3388636272 | 707 | V>I | No | EVA | |
| rs3393320890 | 815 | A>G | No | EVA | |
| rs3388633897 | 821 | K>R | No | EVA | |
| rs3388631162 | 888 | A>T | No | EVA | |
| rs3393280255 | 908 | Y>LT* | No | EVA | |
| rs217611346 | 920 | M>L | No | EVA | |
| rs3388627830 | 986 | G>A | No | EVA | |
| rs3388636265 | 987 | Q>* | No | EVA | |
| rs3541539709 | 998 | A>V | No | EVA | |
| rs3393280302 | 1063 | T>I | No | EVA | |
| rs3388628525 | 1066 | D>N | No | EVA | |
| rs3388632430 | 1128 | T>I | No | EVA | |
| rs3393338349 | 1134 | F>S | No | EVA | |
| rs3393338333 | 1135 | G>E* | No | EVA | |
| rs3388635846 | 1150 | G>V | No | EVA | |
| rs3388641159 | 1198 | N>K | No | EVA | |
| rs3388638866 | 1228 | C>G | No | EVA | |
| rs3388628493 | 1231 | H>Y | No | EVA | |
| rs3541536546 | 1240 | V>L | No | EVA | |
| rs3393320916 | 1241 | H>L | No | EVA | |
| rs3393338381 | 1249 | E>V | No | EVA | |
| rs3541536444 | 1261 | Y>N | No | EVA | |
| rs3388636202 | 1265 | C>S | No | EVA | |
| rs224402533 | 1278 | E>K | No | EVA | |
| rs3388642080 | 1279 | P>T | No | EVA | |
| rs3412213915 | 1295 | N>I | No | EVA | |
| rs3393354892 | 1296 | G>W | No | EVA |
No associated diseases with Q9WTL4
13 regional properties for Q9WTL4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Receptor L-domain | 47 - 157 | IPR000494-1 |
| domain | Receptor L-domain | 346 - 455 | IPR000494-2 |
| domain | Protein kinase domain | 979 - 1254 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 980 - 1245 | IPR001245 |
| conserved_site | Tyrosine-protein kinase, receptor class II, conserved site | 1139 - 1147 | IPR002011 |
| domain | Fibronectin type III | 483 - 603 | IPR003961-1 |
| domain | Fibronectin type III | 605 - 798 | IPR003961-2 |
| domain | Fibronectin type III | 816 - 913 | IPR003961-3 |
| domain | Furin-like cysteine-rich domain | 174 - 329 | IPR006211 |
| repeat | Furin-like repeat | 225 - 275 | IPR006212 |
| active_site | Tyrosine-protein kinase, active site | 1111 - 1123 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 985 - 1013 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 979 - 1246 | IPR020635 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| insulin receptor complex | A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| insulin receptor activity | Combining with insulin receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| insulin receptor substrate binding | Binding to an insulin receptor substrate (IRS) protein, an adaptor protein that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex. |
| phosphatidylinositol 3-kinase binding | Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| cellular response to alkaline pH | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution. |
| male sex determination | The specification of male sex of an individual organism. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
82 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q769I5 | MET | Hepatocyte growth factor receptor | Bos taurus (Bovine) | PR |
| Q05688 | IGF1R | Insulin-like growth factor 1 receptor | Bos taurus (Bovine) | SS |
| A0M8S8 | MET | Hepatocyte growth factor receptor | Felis catus (Cat) (Felis silvestris catus) | PR |
| P09208 | InR | Insulin-like receptor | Drosophila melanogaster (Fruit fly) | SS |
| P29376 | LTK | Leukocyte tyrosine kinase receptor | Homo sapiens (Human) | SS |
| P08069 | IGF1R | Insulin-like growth factor 1 receptor | Homo sapiens (Human) | EV |
| Q04912 | MST1R | Macrophage-stimulating protein receptor | Homo sapiens (Human) | EV |
| P06213 | INSR | Insulin receptor | Homo sapiens (Human) | EV |
| P08581 | MET | Hepatocyte growth factor receptor | Homo sapiens (Human) | EV |
| P08922 | ROS1 | Proto-oncogene tyrosine-protein kinase ROS | Homo sapiens (Human) | SS |
| Q9UM73 | ALK | ALK tyrosine kinase receptor | Homo sapiens (Human) | EV |
| P14616 | INSRR | Insulin receptor-related protein | Homo sapiens (Human) | SS |
| P15208 | Insr | Insulin receptor | Mus musculus (Mouse) | SS |
| P97793 | Alk | ALK tyrosine kinase receptor | Mus musculus (Mouse) | SS |
| Q00993 | Axl | Tyrosine-protein kinase receptor UFO | Mus musculus (Mouse) | PR |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q60805 | Mertk | Tyrosine-protein kinase Mer | Mus musculus (Mouse) | SS |
| Q9Z138 | Ror2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Mus musculus (Mouse) | SS |
| Q3UFB7 | Ntrk1 | High affinity nerve growth factor receptor | Mus musculus (Mouse) | SS |
| Q9Z139 | Ror1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Mus musculus (Mouse) | PR |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| Q60750 | Epha1 | Ephrin type-A receptor 1 | Mus musculus (Mouse) | SS |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| P35546 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Mus musculus (Mouse) | SS |
| Q61006 | Musk | Muscle, skeletal receptor tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| Q62371 | Ddr2 | Discoidin domain-containing receptor 2 | Mus musculus (Mouse) | SS |
| Q03146 | Ddr1 | Epithelial discoidin domain-containing receptor 1 | Mus musculus (Mouse) | SS |
| P15209 | Ntrk2 | BDNF/NT-3 growth factors receptor | Mus musculus (Mouse) | SS |
| Q6VNS1 | Ntrk3 | NT-3 growth factor receptor | Mus musculus (Mouse) | SS |
| P35917 | Flt4 | Vascular endothelial growth factor receptor 3 | Mus musculus (Mouse) | SS |
| P35969 | Flt1 | Vascular endothelial growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P35918 | Kdr | Vascular endothelial growth factor receptor 2 | Mus musculus (Mouse) | PR |
| Q60751 | Igf1r | Insulin-like growth factor 1 receptor | Mus musculus (Mouse) | SS |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| Q62190 | Mst1r | Macrophage-stimulating protein receptor | Mus musculus (Mouse) | SS |
| P55144 | Tyro3 | Tyrosine-protein kinase receptor TYRO3 | Mus musculus (Mouse) | SS |
| P70424 | Erbb2 | Receptor tyrosine-protein kinase erbB-2 | Mus musculus (Mouse) | SS |
| Q61527 | Erbb4 | Receptor tyrosine-protein kinase erbB-4 | Mus musculus (Mouse) | SS |
| Q61526 | Erbb3 | Receptor tyrosine-protein kinase erbB-3 | Mus musculus (Mouse) | SS |
| Q01279 | Egfr | Epidermal growth factor receptor | Mus musculus (Mouse) | SS |
| Q01887 | Ryk | Tyrosine-protein kinase RYK | Mus musculus (Mouse) | PR |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| P05532 | Kit | Mast/stem cell growth factor receptor Kit | Mus musculus (Mouse) | PR |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| P09581 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Mus musculus (Mouse) | SS |
| P26618 | Pdgfra | Platelet-derived growth factor receptor alpha | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| P16056 | Met | Hepatocyte growth factor receptor | Mus musculus (Mouse) | PR |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| P97523 | Met | Hepatocyte growth factor receptor | Rattus norvegicus (Rat) | PR |
| P24062 | Igf1r | Insulin-like growth factor 1 receptor | Rattus norvegicus (Rat) | SS |
| P15127 | Insr | Insulin receptor | Rattus norvegicus (Rat) | SS |
| Q64716 | Insrr | Insulin receptor-related protein | Rattus norvegicus (Rat) | SS |
| Q8I7I5 | rol-3 | Protein roller-3 | Caenorhabditis elegans | PR |
| H2KZU7 | svh-2 | Tyrosine-protein kinase receptor svh-2 | Caenorhabditis elegans | SS |
| Q9SXB5 | At1g11303 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11303 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPZ9 | SD113 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LMN7 | WAK5 | Wall-associated receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64783 | At1g61370 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61370 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64770 | At1g61490 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61490 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SYA0 | At1g61500 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61500 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LW83 | CES101 | G-type lectin S-receptor-like serine/threonine-protein kinase CES101 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSV3 | WAKL16 | Putative wall-associated receptor kinase-like 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M342 | WAKL15 | Wall-associated receptor kinase-like 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZJ9 | CRCK2 | Calmodulin-binding receptor-like cytoplasmic kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81833 | SD11 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64776 | At1g61440 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61440 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64780 | At1g61400 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61400 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64477 | At2g19130 | G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64782 | SD129 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-29 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SY95 | At1g61550 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61550 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64774 | At1g61460 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61460 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SXB4 | At1g11300 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64778 | At1g61420 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61420 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64793 | At1g67520 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g67520 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q39203 | SD22 | G-type lectin S-receptor-like serine/threonine-protein kinase SD2-2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64784 | At1g61360 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61360 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| F1QVU0 | ltk | Tyrosine-protein kinase receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| F8W3R9 | alk | ALK tyrosine kinase receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAVPALWPWG | VHLLMSLLSL | GSGLDTLEVC | PSLDIRSEVT | ELRRLENCSV | VEGHLQILLM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FAATGEDFRG | LSFPRLTQVT | DYLLLFRVYG | LESLRDLFPN | LTVIRGTRLF | LGYALIIFEM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PHLRDVGLPS | LGAVLRGAVR | VEKNQELCHL | STIDWGLLQP | APGTNHIVGN | KLGEECADVC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PGVLGAAGEP | CSRTTFSGRT | DYRCWTSSHC | QKVCPCPRGM | ACTAGGDCCH | SECLGGCSQP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EDPRACVACR | HLYFQGVCLR | ACPPGTYQYE | SWRCVTAELC | AHLREVPGLA | TTFGIYEGSC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LAQCPPGFTR | NGSSIFCHKC | EGLCPKECKV | GTKTIDSVQA | TQDLVGCTHV | EGNLILNLRQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GYNLEPELQR | NLGLVETITG | FLKIKHSFAL | VTLGFFKNLK | LIRGDSMVDG | NYTLYVLDNQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NLQQLGSWVT | AGLTIPVGKI | YFAFNPRLCL | EHIYQLEEVT | GTRGRQSKAE | INPRTNGDRA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ACQTRTLRFV | FNLTEEDRIL | LRWERYEPLE | ARDLLSFIVY | YKESPFQNAT | EHVGPDACGT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QSWNLLDVEL | PLSRTQEPGV | TLAPLKPWTQ | YAVFVRAITL | TTAEDSPHQG | AQSPIVYLRT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LPAAPTVPQD | VISTSNSSSH | LLVRWKPPVQ | RNGNITYYLV | LWQRLAEDGD | LYINDYCHRG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LRLPTSSHDT | RFDREDPALE | AEPEQGCCPC | QHSPPGQALP | ALEAQEVTFQ | KKFENFLHHA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ITIPKAPWKV | TSINKNPQRD | SERHRREAGL | LRLGKNNSDF | EIQEDKVPRE | RAILSGLRHF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| TEYRIDIHAC | NHAAHTVGCS | AATFVFARTM | PHREADGIPG | KVAWKAAGKS | SVTLHWLEPP |
| 850 | 860 | 870 | 880 | 890 | 900 |
| DPNGLILKYE | IKYRRLGEEA | TVLCVSRLRY | AKVGGVHLAL | LPPGNYSAKV | RATSLAGNGS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| WTDGVTFYIT | DLEEEDTGGM | RIFLTVTPVG | FMLLVTLAAL | GFFYSRKRNS | TLYTSVNPEY |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| FSASHMYVPD | EWEVPREQIA | IIRELGQGSF | GMVYEGLARG | LEAGEESTPV | ALKTVNELAS |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| ARERVEFLKE | ASVMKAFKCH | HVVRLLGVVS | QGQPTLVIME | LMTRGDLKSH | LRSLRPEAEN |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| NPGLPQPALS | DMIQMAGEIA | DGMAYLAAKK | FVHRDLAARN | CMVSQDFTVK | IGDFGMTRDV |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| YETDYYRKGG | KGLLPVRWMA | PESLKDGIFT | THSDVWSFGV | VLWEIVTLAE | QPYQGLSNEQ |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| VLKFVMDGGV | LEELENCPIQ | LQELMRLCWQ | HSPRLRPTFV | HILDRIQDEL | RPSFRLCSFY |
| 1270 | 1280 | 1290 | |||
| YSPECQRGQA | SLLPTEAEPD | SPPTLNGASD | YSAPNGGPGH |