Q39203
SS
Gene name |
SD22 (RLK4, At4g00340, A_IG005I10.19, F5I10.19) |
Protein name |
G-type lectin S-receptor-like serine/threonine-protein kinase SD2-2 |
Names |
EC 2.7.11.1 , Receptor-like kinase 4 , S-domain-2 , SD2 receptor kinase 2 , SD2-2 |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
ath:AT4G00340 |
EC number |
2.7.11.18: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
Myosin light chain kinases (MLCK) are members of the family of Ca2+-calmodulin-dependent protein kinases. This enzyme contains an autoinhibitory pseudosubstrate sequence that blocks the substrate-binding site of the kinase. The autoinhibitory sequence makes an extensive network of contacts on the surface of the larger C-domain of the catalytic core extending towards the catalytic cleft with the CaM-binding sequence to block the regulatory light chain of sarcomeric myosin, but not ATP binding in the catalytic core N-domain.
Autoinhibitory domains (AIDs)
Accessory elements
602-626 (Activation loop from InterPro)
Target domain |
461-742 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
Autoinhibited structure
Activated structure
1 structures for Q39203
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q39203-F1 | Predicted | AlphaFoldDB |
No variants for Q39203
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q39203 | |||||
No associated diseases with Q39203
10 regional properties for Q39203
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Kringle | 314 - 396 | IPR000001 |
| domain | Protein kinase domain | 473 - 746 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 474 - 746 | IPR001245 |
| domain | Immunoglobulin subtype 2 | 74 - 142 | IPR003598 |
| domain | Immunoglobulin subtype | 68 - 153 | IPR003599 |
| domain | Immunoglobulin-like domain | 55 - 145 | IPR007110 |
| active_site | Tyrosine-protein kinase, active site | 611 - 623 | IPR008266 |
| domain | Immunoglobulin I-set | 64 - 150 | IPR013098 |
| conserved_site | Kringle, conserved site | 364 - 377 | IPR018056 |
| domain | Frizzled domain | 169 - 303 | IPR020067 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.18 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| carbohydrate binding | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| recognition of pollen | A cell recognition process in which pollen is recognized and either accepted or rejected by cells in the stigma. |
33 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q06807 | TEK | Angiopoietin-1 receptor | Bos taurus (Bovine) | SS |
| Q06805 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Bos taurus (Bovine) | PR |
| P43481 | KIT | Mast/stem cell growth factor receptor Kit | Bos taurus (Bovine) | SS |
| Q28889 | KIT | Mast/stem cell growth factor receptor Kit | Felis catus (Cat) (Felis silvestris catus) | SS |
| P13369 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Felis catus (Cat) (Felis silvestris catus) | SS |
| Q8AXY6 | MUSK | Muscle, skeletal receptor tyrosine protein kinase | Gallus gallus (Chicken) | SS |
| P09208 | InR | Insulin-like receptor | Drosophila melanogaster (Fruit fly) | SS |
| P08069 | IGF1R | Insulin-like growth factor 1 receptor | Homo sapiens (Human) | EV |
| P14616 | INSRR | Insulin receptor-related protein | Homo sapiens (Human) | SS |
| P06213 | INSR | Insulin receptor | Homo sapiens (Human) | EV |
| P35590 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Homo sapiens (Human) | PR |
| Q02763 | TEK | Angiopoietin-1 receptor | Homo sapiens (Human) | SS |
| Q01973 | ROR1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Homo sapiens (Human) | PR |
| Q01974 | ROR2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Homo sapiens (Human) | EV |
| P30530 | AXL | Tyrosine-protein kinase receptor UFO | Homo sapiens (Human) | PR |
| P15208 | Insr | Insulin receptor | Mus musculus (Mouse) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| Q60751 | Igf1r | Insulin-like growth factor 1 receptor | Mus musculus (Mouse) | SS |
| Q9WTL4 | Insrr | Insulin receptor-related protein | Mus musculus (Mouse) | SS |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| Q9Z139 | Ror1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Mus musculus (Mouse) | PR |
| Q9Z138 | Ror2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Mus musculus (Mouse) | SS |
| P15209 | Ntrk2 | BDNF/NT-3 growth factors receptor | Mus musculus (Mouse) | SS |
| Q6VNS1 | Ntrk3 | NT-3 growth factor receptor | Mus musculus (Mouse) | SS |
| Q64716 | Insrr | Insulin receptor-related protein | Rattus norvegicus (Rat) | SS |
| P15127 | Insr | Insulin receptor | Rattus norvegicus (Rat) | SS |
| P24062 | Igf1r | Insulin-like growth factor 1 receptor | Rattus norvegicus (Rat) | SS |
| Q62838 | Musk | Muscle, skeletal receptor tyrosine protein kinase | Rattus norvegicus (Rat) | SS |
| P57097 | Mertk | Tyrosine-protein kinase Mer | Rattus norvegicus (Rat) | SS |
| Q94C25 | At5g20050 | Probable receptor-like protein kinase At5g20050 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64477 | At2g19130 | G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O73791 | tek | Angiopoietin-1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGTSLYRSTL | LSTGGFSVSD | YIRKFTKNKP | DVNNIQPNVG | FCHQSTQTSQ | QVKEVISAEL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ELQQPEVTLP | NDPSSQHSPE | AHTGASEPLK | PVSAGESSKA | LQKAKEISVK | SSEPTHVQTF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| APAVHLEQID | VHNVPKQETN | SLVAAPADAK | CVIETMTKVE | KDIALQQERA | LERADDSHVA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NKVFLKSIIP | GQQLEKIEDP | QQQAEVSLFV | DEDSLEKSVP | GQHLDKKMEV | LQKQAKDLPV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VDEDSLNLSA | PGQRQLEEKV | DVPEKAEKKI | DEAHKKMEEV | PRKDELCIEK | PVIRHAGIKT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QHEETMGMET | TVPKHDESKC | PTETYVEKTE | NKNADVTLES | DKIMICAVSP | QNTSLDEDEK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SKAAPLRKVE | STLLIIDDSP | PLPAPFDHRI | VSAKQVPINS | YYAVNPVEVL | GGGRFGQVHK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CAELSSGLTL | AAKIIKVRGM | KERDEVKNEI | GVMNQLNHVN | LIQLYDAFES | RTNLTLIMEY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VEGGELFERI | IDESYQLTEL | DAIVFTRQIC | EGVQYLHQQY | ILHLDLKPEN | ILCVNSTGNQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IKIIDFGLAR | KYRPREKLKV | NFGTPEFLAP | EVVNYDFVSF | PTDMWSVGVI | TYMLLSGLSP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FMGDNDAETM | NNILHAKWEF | DTEAFENVSE | EAKDFISSLL | VSAKCSRLSA | SGCMKHSWLN |
| 670 | 680 | 690 | 700 | 710 | |
| NLEDKAKMYK | VRLKSQMMLQ | RYLVAHRQWK | KHFYAVAAAN | RLKRFQQSRS | ISTPN |