Q9W740

PR
Gene name
nog2
Protein name
Noggin-2
Names
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:30185
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-140 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9W740

Entry ID Method Resolution Chain Position Source
AF-Q9W740-F1 Predicted AlphaFoldDB

No variants for Q9W740

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9W740

No associated diseases with Q9W740

7 regional properties for Q9W740

Type Name Position InterPro Accession
domain GTP binding domain 171 - 191 IPR006073-1
domain GTP binding domain 192 - 210 IPR006073-2
domain GTP binding domain 219 - 234 IPR006073-3
domain Nucleolar GTP-binding protein 1, Rossman-fold domain 235 - 292 IPR010674
domain NOG, C-terminal 396 - 449 IPR012973
domain OBG-type guanine nucleotide-binding (G) domain 169 - 341 IPR031167
domain NOG1, N-terminal helical domain 6 - 165 IPR041623

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

5 GO annotations of biological process

Name Definition
cartilage development The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
dorsal/ventral pattern formation The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
negative regulation of BMP signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
negative regulation of cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.
osteoblast differentiation The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9YHV3 nog3 Noggin-3 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MGSITRALPL LLLLLLCAHG TASQHHLRLR PLPSEGLPVP DLIENPDPEH DPREQDLSEK
70 80 90 100 110 120
TLLKKLGSNF DANFMSIHLP AQLNASAPPE LPRLPMPAEL KKLDLTETPY GRRVKVGKKA
130 140 150 160 170 180
RRKFLQWLWM YTHCPVLYTW KDLGLRFWPR YIKEGNCFSE RSCSFPEGMS CKPVKAVTKT
190 200 210
FLRWYCQGFM RQKYCTWIQV QYPIISQCKC SC