Q9W4Y2

PR
Gene name
Pdfr
Protein name
PDF receptor
Names
Pigment-dispersing factor receptor, Protein groom-of-PDF
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG13758
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-81 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9W4Y2

Entry ID Method Resolution Chain Position Source
AF-Q9W4Y2-F1 Predicted AlphaFoldDB

No variants for Q9W4Y2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9W4Y2

No associated diseases with Q9W4Y2

4 regional properties for Q9W4Y2

Type Name Position InterPro Accession
domain GPCR, family 2, extracellular hormone receptor domain 130 - 222 IPR001879
domain GPCR, family 2-like, transmembrane domain 240 - 502 IPR017981
conserved_site GPCR, family 2, secretin-like, conserved site 147 - 171 IPR017983-1
conserved_site GPCR, family 2, secretin-like, conserved site 490 - 505 IPR017983-2

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
calcitonin receptor activity Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
G protein-coupled peptide receptor activity Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
neuropeptide receptor activity Combining with a neuropeptide to initiate a change in cell activity.
peptide hormone binding Binding to a peptide with hormonal activity in animals.

16 GO annotations of biological process

Name Definition
adenylate cyclase-activating G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP).
adenylate cyclase-modulating G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP).
cell surface receptor signaling pathway The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
circadian behavior The specific behavior of an organism that recurs with a regularity of approximately 24 hours.
circadian rhythm Any biological process in an organism that recurs with a regularity of approximately 24 hours.
circadian sleep/wake cycle The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm.
circadian temperature homeostasis Any homeostatic process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours.
copper ion homeostasis Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell.
G protein-coupled receptor signaling pathway The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
gravitaxis The directed movement of a motile cell or organism in response to gravity.
locomotor rhythm The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.
neuropeptide signaling pathway A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
positive regulation of calcium-mediated signaling Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling.
regulation of circadian rhythm Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
regulation of circadian sleep/wake cycle Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle.
response to paraquat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paraquat stimulus.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q09460 pdfr-1 Calcitonin receptor-like protein 1 Caenorhabditis elegans PR
10 20 30 40 50 60
MTLLSNILDC GGCISAQRFT RLLRQSGSSG PSPSAPTAGT FESKSMLEPT SSHSLATGRV
70 80 90 100 110 120
PLLHDFDAST TESPGTYVLD GVARVAQLAL EPTVMDALPD SDTEQVLGNL NSSAPWNLTL
130 140 150 160 170 180
ASAAATNFEN CSALFVNYTL PQTGLYCNWT WDTLLCWPPT PAGVLARMNC PGGFHGVDTR
190 200 210 220 230 240
KFAIRKCELD GRWGSRPNAT EVNPPGWTDY GPCYKPEIIR LMQQMGSKDF DAYIDIARRT
250 260 270 280 290 300
RTLEIVGLCL SLFALIVSLL IFCTFRSLRN NRTKIHKNLF VAMVLQVIIR LTLYLDQFRR
310 320 330 340 350 360
GNKEAATNTS LSVIENTPYL CEASYVLLEY ARTAMFMWMF IEGLYLHNMV TVAVFQGSFP
370 380 390 400 410 420
LKFFSRLGWC VPILMTTVWA RCTVMYMDTS LGECLWNYNL TPYYWILEGP RLAVILLNFC
430 440 450 460 470 480
FLVNIIRVLV MKLRQSQASD IEQTRKAVRA AIVLLPLLGI TNLLHQLAPL KTATNFAVWS
490 500 510 520 530 540
YGTHFLTSFQ GFFIALIYCF LNGEVRAVLL KSLATQLSVR GHPEWAPKRA SMYSGAYNTA
550 560 570 580 590 600
PDTDAVQPAG DPSATGKRIS PPNKRLNGRK PSSASIVMIH EPQQRQRLMP RLQNKAREKG
610 620 630 640 650 660
KDRVEKTDAE AEPDPTISHI HSKEAGSARS RTRGSKWIMG ICFRGQKVLR VPSASSVPPE
SVVFELSEQ