Q9W4J5
Gene name |
CG3527 |
Protein name |
Ribosomal RNA small subunit methyltransferase NEP1 |
Names |
18S rRNA (pseudouridine-N1)-methyltransferase, Ribosome biogenesis protein NEP1 |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG3527 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9W4J5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9W4J5-F1 | Predicted | AlphaFoldDB |
No variants for Q9W4J5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9W4J5 | |||||
No associated diseases with Q9W4J5
No regional properties for Q9W4J5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9W4J5 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| small-subunit processome | A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| rRNA (pseudouridine) methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule. |
| rRNA binding | Binding to a ribosomal RNA. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| defense response to bacterium | Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. |
| rRNA base methylation | The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule. |
| rRNA methylation | The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q92979 | EMG1 | Ribosomal RNA small subunit methyltransferase NEP1 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGGQGKAINR | KRKFVGRKAD | DPEFDLDKKQ | FKVLHLNATE | KRLIIVLEGA | QLETVKVHNT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FELLNCDDHA | GIMRKNQRDP | GSCRPDITHQ | CLLMLFDSPL | NRAGLLQVFV | RTEHNVLIEI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NPQTRIPRTF | KRFAGLMVQL | LHKFQIRAND | SSRRLMSVIK | NPITDHVPVG | CKKYAMSFSG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KLLPNCRDLV | PHGDETSASY | DEPVVIVIGA | FAHGVLKTDY | TEELFSISNY | PLSAAIACSK |
| 250 | |||||
| ICSAFEEVWG | VV |