AiPD: Autoinhibited Protein Database

Q92979

Gene name	EMG1
Protein name	Ribosomal RNA small subunit methyltransferase NEP1
Names	18S rRNA (pseudouridine(1248)-N1)-methyltransferase, 18S rRNA Psi1248 methyltransferase, Nucleolar protein EMG1 homolog, Protein C2f, Ribosome biogenesis protein NEP1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10436
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-47 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

5 structures for Q92979

Entry ID	Method	Resolution	Chain	Position	Source
5FAI	X-ray	180 A	A	14-244	PDB
7MQ8	EM	360 A	SJ/SK	1-244	PDB
7MQ9	EM	387 A	SJ/SK	1-244	PDB
7MQA	EM	270 A	SJ/SK	1-244	PDB
AF-Q92979-F1	Predicted				AlphaFoldDB

232 variants for Q92979

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV000947413 rs60117710 RCV001664562	43	L>missing	Bowen-Conradi syndrome [ClinVar]	Yes	ClinVar dbSNP
RCV000000938 CA114613 VAR_062480 rs74435397	86	D>G	Bowen-conradi syndrome (bwcns) Bowen-Conradi syndrome BWCNS; studies in fibroblasts show a dramatically reduced level of EMG1 protein in a BWCNS-affected patient compared to normal fibroblasts although patient fibroblasts do not have complete EMG1 deficiency; the mutation increases dimerization of EMG1 subunits suggesting that aggregation of EMG1 leads to reduced levels of the protein [Ensembl, ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt ExAC TOPMed dbSNP gnomAD
CA383680276 rs1555152059	2	A>V		No	ClinGen gnomAD
rs376055535 CA6422598	5	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA383680317 rs149578211	5	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6422600 rs782711576	6	D>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs782118451 CA383680333	7	G>*		No	ClinGen ExAC TOPMed gnomAD
rs782778398 CA6422602	7	G>A		No	ClinGen ExAC TOPMed gnomAD
rs782778398 CA383680335	7	G>E		No	ClinGen ExAC TOPMed gnomAD
rs782118451 CA6422601	7	G>R		No	ClinGen ExAC TOPMed gnomAD
CA383680358 rs782550075	8	F>L		No	ClinGen ExAC
CA383680341 rs1231453871	8	F>V		No	ClinGen TOPMed
CA6422607 rs782722332 CA6422606	9	K>N		No	ClinGen ExAC gnomAD
CA383680379 rs1320278594	10	P>S		No	ClinGen TOPMed gnomAD
CA383680388 rs782479150	11	R>C		No	ClinGen ExAC gnomAD
CA232443112 rs372361920	11	R>P		No	ClinGen ESP gnomAD
CA6422608 rs782479150	11	R>S		No	ClinGen ExAC gnomAD
CA383680397 rs1555152086	12	E>K		No	ClinGen gnomAD
CA383680413 rs782628939	13	R>*		No	ClinGen ExAC TOPMed gnomAD
CA6422610 RCV000514815 rs36061201	13	R>L		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs782546340 CA6422612	14	S>N		No	ClinGen ExAC gnomAD
rs782249279 CA232443118	14	S>R		No	ClinGen Ensembl
rs782546340 CA6422611	14	S>T		No	ClinGen ExAC gnomAD
CA6422613 rs782175380	15	G>C		No	ClinGen ExAC gnomAD
rs782604752 CA6422616	16	G>E		No	ClinGen ExAC TOPMed gnomAD
rs782324364 CA6422615	16	G>W		No	ClinGen ExAC gnomAD
rs1338492839 CA383680462	17	E>V		No	ClinGen TOPMed
rs782233712 CA6422617	18	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs1402722258 CA383680471	18	Q>R		No	ClinGen TOPMed
CA6422619 rs369617092	19	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6422620 rs369617092	19	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1555152118 CA383680484	19	A>V		No	ClinGen gnomAD
CA6422621 rs782150637	20	Q>R		No	ClinGen ExAC gnomAD
CA383680509 rs906784380	21	D>E		No	ClinGen gnomAD
CA6422622 rs782438220	21	D>N		No	ClinGen ExAC TOPMed gnomAD
CA383680536 rs1555152123	22	W>C		No	ClinGen gnomAD
CA383680540 rs1555152124	23	D>N		No	ClinGen gnomAD
rs1555152126 CA383680564	24	A>D		No	ClinGen gnomAD
CA383680579 rs1555152130	25	L>P		No	ClinGen gnomAD
rs782075048 CA383680596	27	P>H		No	ClinGen ExAC gnomAD
rs782075048 CA6422624	27	P>L		No	ClinGen ExAC gnomAD
rs782743040 CA6422625	28	K>Q		No	ClinGen ExAC gnomAD
CA232443138 rs1003756868	28	K>R		No	ClinGen gnomAD
CA383680603 rs1003756868	28	K>T		No	ClinGen gnomAD
rs781851789 CA6422626	30	P>L		No	ClinGen ExAC gnomAD
rs782126924 CA6422627	31	R>*		No	ClinGen ExAC TOPMed gnomAD
CA383680733 rs1370835199	33	G>E		No	ClinGen TOPMed gnomAD
VAR_050237 RCV000202817 rs11064480 CA249018	34	A>G		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA6422630 rs782495453	34	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs782495453 CA6422629	34	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA232443144 rs3168594	35	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA232443148 rs952438354	37	K>E		No	ClinGen Ensembl
CA6422632 rs781824161	38	I>S		No	ClinGen ExAC gnomAD
rs782633987 CA6422634	39	G>E		No	ClinGen ExAC TOPMed gnomAD
CA383680886 rs1555152153	40	G>D		No	ClinGen gnomAD
CA6422635 rs782266941	41	R>C		No	ClinGen ExAC TOPMed gnomAD
rs782414000 CA6422636	41	R>H		No	ClinGen ExAC gnomAD
CA232443159 rs200041551	42	R>G		No	ClinGen Ensembl
TCGA novel	42	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs17857448 CA232443166 CA232443164	42	R>S		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	43	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1218217281 CA383681046	48	E>K		No	ClinGen TOPMed
rs781966739 CA6422639	50	A>T		No	ClinGen ExAC gnomAD
rs782103478 CA6422640	51	S>I		No	ClinGen ExAC TOPMed gnomAD
CA383681129 rs375042715	52	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA383681178 rs1555152172	54	T>I		No	ClinGen gnomAD
rs1555152177 CA383681182	55	V>I		No	ClinGen gnomAD
rs1591705284 CA383681204	56	K>Q		No	ClinGen Ensembl
rs1555152678 CA383682480	59	K>R		No	ClinGen gnomAD
rs373473870 CA383682503	61	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs1555152684	61	Y>*	Variant assessed as Somatic; 4.659e-05 impact. [NCI-TCGA]	No	NCI-TCGA
CA6422662 rs782339755	61	Y>C		No	ClinGen ExAC gnomAD
rs782793844 CA6422665	63	L>V		No	ClinGen ExAC gnomAD
rs782174904 CA6422667	65	N>S		No	ClinGen ExAC gnomAD
rs1464487209 CA383682602	66	C>Y		No	ClinGen TOPMed
CA6422668 rs782707397	67	D>E		No	ClinGen ExAC gnomAD
rs782483867 CA6422670	69	H>R		No	ClinGen ExAC gnomAD
rs782521916 CA6422673	72	I>M		No	ClinGen ExAC gnomAD
rs377272519 CA6422672	72	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs782749715 CA6422671	72	I>V		No	ClinGen ExAC TOPMed gnomAD
rs782172949 CA383682765	73	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1555152708 CA383682809	76	N>D		No	ClinGen gnomAD
CA383682838 rs1555152709	76	N>S		No	ClinGen gnomAD
CA6422677 rs782601712	77	G>E		No	ClinGen ExAC gnomAD
CA383682881 rs782179643	78	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs782693598 CA6422681	78	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA6422679 rs782179643	78	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA383682912 rs1387282151	79	D>G		No	ClinGen TOPMed gnomAD
CA383682907 rs1555152718	79	D>Y		No	ClinGen gnomAD
CA6422682 rs782276276	81	G>V		No	ClinGen ExAC TOPMed gnomAD
rs782422549 CA6422683	83	A>G		No	ClinGen ExAC TOPMed gnomAD
rs1555152726 CA383682979	83	A>T		No	ClinGen gnomAD
rs782422549 CA6422684	83	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs782735967 CA6422686	84	R>Q		No	ClinGen ExAC gnomAD
rs782803599 CA6422688	87	I>T		No	ClinGen ExAC gnomAD
CA6422689 rs781896004	88	T>A		No	ClinGen ExAC gnomAD
CA383683137 rs1392318274	89	H>Y		No	ClinGen TOPMed gnomAD
CA6422691 rs782703604	90	Q>E		No	ClinGen ExAC gnomAD
rs1555152776 CA383683308	91	S>G		No	ClinGen gnomAD
CA6422716 rs781910054	94	M>I		No	ClinGen ExAC gnomAD
rs782169084 CA6422715	94	M>R		No	ClinGen 1000Genomes ExAC gnomAD
rs782580920 CA6422718	95	L>P		No	ClinGen ExAC gnomAD
rs782456048 CA6422717	95	L>V		No	ClinGen ExAC gnomAD
CA6422719 rs781831826	98	S>N		No	ClinGen ExAC gnomAD
CA6422720 rs782486688	99	P>L		No	ClinGen ExAC gnomAD
rs782438469 CA232443863	100	L>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6422723 rs782418214	102	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs782563434 CA6422724	102	R>Q		No	ClinGen ExAC gnomAD
CA6422726 rs782190613	103	A>G		No	ClinGen ExAC gnomAD
CA6422725 rs782190613	103	A>V		No	ClinGen ExAC gnomAD
CA383683568 rs1256862599	104	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA383683573 rs1256862599	104	G>V		No	ClinGen TOPMed
rs781966629 CA6422727	106	L>V		No	ClinGen ExAC
rs1555152797 CA383683605	107	Q>*		No	ClinGen gnomAD
CA6422729 rs782648414	108	V>A		No	ClinGen ExAC
rs1276535579 CA383683655	110	I>M		No	ClinGen TOPMed
rs1484616063 CA383683653	110	I>S		No	ClinGen TOPMed
rs993652525 CA232443878	111	H>R		No	ClinGen TOPMed gnomAD
rs199566199 CA6422731	113	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA6422733 rs782018212	114	K>*		No	ClinGen ExAC
CA383683710 CA383683708 rs1555152809	114	K>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1555152813 CA383683719	115	N>S		No	ClinGen gnomAD
TCGA novel	116	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6422734 rs782169969	118	I>T		No	ClinGen ExAC gnomAD
CA383683750 rs1246417980	118	I>V		No	ClinGen TOPMed
CA383683783 rs1555152817	120	V>M		No	ClinGen gnomAD
CA6422736 rs781939868	122	P>A		No	ClinGen ExAC gnomAD
rs781812160 CA6422737	122	P>R		No	ClinGen 1000Genomes ExAC gnomAD
CA383683873 rs1555152820	124	T>I		No	ClinGen TOPMed gnomAD
CA383683868 rs1555152820	124	T>N		No	ClinGen TOPMed gnomAD
CA6422740 rs782538249	125	R>*		No	ClinGen ExAC TOPMed gnomAD
CA383683881 rs1555152823	125	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1309066030 CA383683912	127	P>L		No	ClinGen TOPMed
CA6422741 rs782808257	129	T>I		No	ClinGen ExAC TOPMed gnomAD
rs782453517 CA6422743	133	F>L		No	ClinGen ExAC gnomAD
rs782226901 CA6422745	136	L>H		No	ClinGen ExAC
rs781867583 CA6422766	141	L>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	145	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6422767 rs782548320	145	S>N		No	ClinGen ExAC gnomAD
rs782675633 CA6422768	146	V>A		No	ClinGen ExAC gnomAD
CA6422769 rs782181464	147	R>*		No	ClinGen ExAC TOPMed gnomAD
CA6422770 rs782181464	147	R>G		No	ClinGen ExAC TOPMed gnomAD
CA383684299 rs1555152914	147	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1171472029 CA383684313	149	A>P		No	ClinGen TOPMed gnomAD
CA6422772 rs782235442	150	D>N		No	ClinGen ExAC TOPMed gnomAD
rs782008843 CA6422774	152	P>L		No	ClinGen ExAC gnomAD
CA232443969 rs782441349	152	P>T		No	ClinGen TOPMed gnomAD
rs782301311 CA6422776	154	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs1555152940 CA383684428	158	V>L		No	ClinGen gnomAD
CA6422789 rs782493737	159	I>T		No	ClinGen ExAC gnomAD
rs1284796548 CA383684458	161	N>S		No	ClinGen TOPMed
CA6422791 rs781882780	162	P>L		No	ClinGen ExAC gnomAD
CA6422790 rs782643000	162	P>S		No	ClinGen ExAC TOPMed gnomAD
CA6422792 rs372110507	163	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6422793 rs782554231	164	S>*		No	ClinGen ExAC gnomAD
rs782554231 CA383684487	164	S>L		No	ClinGen ExAC gnomAD
CA6422794 rs183026884	167	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1555152950 CA383684526	168	P>Q		No	ClinGen gnomAD
CA383684532 rs1555152952	169	V>L		No	ClinGen gnomAD
CA6422795 rs782334197	171	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA383684598 CA6422797 rs782245976	172	M>I		No	ClinGen ExAC TOPMed gnomAD
CA383684590 rs1169305243	172	M>T		No	ClinGen TOPMed
rs1555152957 CA383684603	173	K>E		No	ClinGen gnomAD
CA6422798 rs782391946	174	V>A		No	ClinGen ExAC TOPMed gnomAD
CA383684685 rs1555152961	178	F>S		No	ClinGen gnomAD
CA383684684 rs1555152961	178	F>Y		No	ClinGen gnomAD
CA6422799 rs782019701	179	S>Y		No	ClinGen ExAC gnomAD
CA6422800 rs782168206	181	P>L		No	ClinGen ExAC TOPMed gnomAD
rs782168206 CA383684743	181	P>R		No	ClinGen ExAC TOPMed gnomAD
rs782307546 CA6422801	182	V>G		No	ClinGen ExAC TOPMed gnomAD
CA383684747 rs1184862119	182	V>I		No	ClinGen TOPMed gnomAD
rs1202716378 CA383684768	183	V>D		No	ClinGen TOPMed
rs781937222 CA6422802	184	S>N		No	ClinGen ExAC TOPMed gnomAD
CA383684829 rs1232720535	186	V>A		No	ClinGen TOPMed gnomAD
CA383684831 rs1232720535	186	V>G		No	ClinGen TOPMed gnomAD
rs201757338 CA6422803	186	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs782741904 CA6422804	187	R>C		No	ClinGen ExAC TOPMed gnomAD
rs782021249 CA383684854	187	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs782021249 CA6422805	187	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs782416705 CA6422807	190	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1555152978 CA383684962	193	S>N		No	ClinGen gnomAD
CA383684986 rs1555152980	195	P>T		No	ClinGen gnomAD
rs375741608 CA232444017	196	I>M		No	ClinGen Ensembl
CA6422810 rs782605254	196	I>V		No	ClinGen ExAC TOPMed gnomAD
CA6422811 rs781834410	197	V>A		No	ClinGen ExAC TOPMed gnomAD
CA383685011 rs1326057506	197	V>F		No	ClinGen TOPMed
rs1326057506 CA383685008	197	V>I		No	ClinGen TOPMed
CA383685044 rs1555152988	199	V>A		No	ClinGen gnomAD
TCGA novel	199	V>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	200	V>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	201	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs971421303 CA232444021	202	A>D		No	ClinGen Ensembl
rs782511052 CA6422812	202	A>T		No	ClinGen ExAC gnomAD
CA383685111 rs868957078	204	A>V		No	ClinGen Ensembl
rs1591708751 CA383685123	205	H>P		No	ClinGen Ensembl
rs1555152994 CA383685138	206	G>D		No	ClinGen gnomAD
CA383685157 rs1407750518	207	K>R		No	ClinGen TOPMed
rs1555153061 CA383685180	208	V>I		No	ClinGen gnomAD
CA6422824 rs782044745	211	E>A		No	ClinGen ExAC gnomAD
rs782710641 CA6422825	213	T>I		No	ClinGen ExAC TOPMed gnomAD
rs200470095 CA6422827	214	E>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6422826 rs781943557	214	E>K		No	ClinGen ExAC gnomAD
rs200470095 CA383685269	214	E>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs782751710 CA6422828	216	M>T		No	ClinGen ExAC gnomAD
CA6422830 rs782527998	217	V>A		No	ClinGen ExAC TOPMed gnomAD
CA6422829 rs781869060	217	V>M		No	ClinGen ExAC gnomAD
CA383685331 rs1371430452	218	S>F		No	ClinGen TOPMed
rs1555153073 CA383685320	218	S>T		No	ClinGen gnomAD
CA383686781 rs782819014	219	I>N		No	ClinGen ExAC gnomAD
CA6422831 rs782819014	219	I>T		No	ClinGen ExAC gnomAD
CA6422832 rs781792612	220	S>N		No	ClinGen ExAC TOPMed gnomAD
CA383686847 rs1034343918	222	Y>*		No	ClinGen gnomAD
CA383686841 rs1258116000	222	Y>C		No	ClinGen TOPMed
rs1476171611 CA383686835	222	Y>H		No	ClinGen TOPMed
rs74396478 CA6422833	223	P>S		No	ClinGen 1000Genomes ExAC gnomAD
rs3180956 CA383686893	225	S>F		No	ClinGen Ensembl
rs1555153080 CA383686907	226	A>G		No	ClinGen gnomAD
CA6422835 rs782235929	226	A>T		No	ClinGen ExAC gnomAD
CA6422836 rs782517421	229	T>P		No	ClinGen ExAC gnomAD
rs782647932 CA6422837	229	T>S		No	ClinGen ExAC
CA6422839 rs369750549	230	C>R		No	ClinGen ESP ExAC gnomAD
CA383687026 rs1252320547	233	L>F		No	ClinGen TOPMed
rs1555153085 CA383687049	234	T>N		No	ClinGen gnomAD
rs187673472 CA6422843	235	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6422844 rs374223610	236	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs1336172483 CA383687146	238	E>K		No	ClinGen TOPMed
CA383687221 rs1231926897	240	V>I		No	ClinGen TOPMed gnomAD
CA383687317 rs1555153095	241	W>*		No	ClinGen gnomAD
TCGA novel	242	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782102656	243	V>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs782051183 CA6422848	243	V>L		No	ClinGen ExAC gnomAD
rs377663713 CA6422849	244	I>V		No	ClinGen ESP ExAC TOPMed gnomAD

No associated diseases with Q92979

No regional properties for Q92979

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q92979

Functions

		Description
EC Number
Subcellular Localization	Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
chromosome	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
small-subunit processome	A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.

4 GO annotations of molecular function

Name	Definition
identical protein binding	Binding to an identical protein or proteins.
RNA binding	Binding to an RNA molecule or a portion thereof.
rRNA (pseudouridine) methyltransferase activity	Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule.
rRNA binding	Binding to a ribosomal RNA.

5 GO annotations of biological process

Name	Definition
blastocyst development	The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.
nucleologenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells.
ribosomal small subunit biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.
rRNA base methylation	The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule.
rRNA processing	Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9W4J5	CG3527	Ribosomal RNA small subunit methyltransferase NEP1	Drosophila melanogaster (Fruit fly)	PR

10	20	30	40	50	60
MAAPSDGFKP	RERSGGEQAQ	DWDALPPKRP	RLGAGNKIGG	RRLIVVLEGA	SLETVKVGKT
70	80	90	100	110	120
YELLNCDKHK	SILLKNGRDP	GEARPDITHQ	SLLMLMDSPL	NRAGLLQVYI	HTQKNVLIEV
130	140	150	160	170	180
NPQTRIPRTF	DRFCGLMVQL	LHKLSVRAAD	GPQKLLKVIK	NPVSDHFPVG	CMKVGTSFSI
190	200	210	220	230	240
PVVSDVRELV	PSSDPIVFVV	GAFAHGKVSV	EYTEKMVSIS	NYPLSAALTC	AKLTTAFEEV

WGVI