Q9VYB7

PR
Gene name
Tpst
Protein name
Protein-tyrosine sulfotransferase
Names
Transport and Golgi organization protein 13, Tango-13, Tyrosylprotein sulfotransferase
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG32632
EC number
2.8.2.20: Sulfotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

243-499 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VYB7

Entry ID Method Resolution Chain Position Source
AF-Q9VYB7-F1 Predicted AlphaFoldDB

No variants for Q9VYB7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VYB7

No associated diseases with Q9VYB7

3 regional properties for Q9VYB7

Type Name Position InterPro Accession
conserved_site Cathelicidin, conserved site 35 - 48 IPR018216-1
conserved_site Cathelicidin, conserved site 79 - 101 IPR018216-2
domain Cathelicidin, antimicrobial peptide, C-terminal 136 - 162 IPR022746

Functions

Description
EC Number 2.8.2.20 Sulfotransferases
Subcellular Localization
  • Golgi apparatus membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
protein-tyrosine sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate.
sulfotransferase activity Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.

2 GO annotations of biological process

Name Definition
peptidyl-tyrosine sulfation The sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine.
protein secretion The controlled release of proteins from a cell.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q20351 tpst-2 Putative protein-tyrosine sulfotransferase Caenorhabditis elegans PR
10 20 30 40 50 60
MRLPYRNKKV TLWVLFGIIV ITMFLFKFTE LRPTCLFKVD AANELSSQMV RVEKYLTDDN
70 80 90 100 110 120
QRVYSYNREM PLIFIGGVPR SGTTLMRAML DAHPDVRCGQ ETRVIPRILQ LRSHWLKSEK
130 140 150 160 170 180
ESLRLQEAGI TKEVMNSAIA QFCLEIIAKH GEPAPRLCNK DPLTLKMGSY VIELFPNAKF
190 200 210 220 230 240
LFMVRDGRAT VHSIISRKVT ITGFDLSSYR QCMQKWNHAI EVMHEQCRDI GKDRCMMVYY
250 260 270 280 290 300
EQLVLHPEEW MRKILKFLDV PWNDAVLHHE EFINKPNGVP LSKVERSSDQ VIKPVNLEAM
310 320 330 340 350 360
SKWVGQIPGD VVRDMADIAP MLSVLGYDPY ANPPDYGKPD AWVQDNTSKL KANRMLWESK
370 380 390 400 410 420
AKQVLQMSSS EDDNTNTIIN NSNNKDNNNN QYTINKIIPE QHSRQRQHVQ QQHLQQQQQQ
430 440 450 460 470 480
HLQQQQHQRQ QQQQQREEES ESEREAEPDR EQQLLHQKPK DVITIKQLPL AGSNNNNINN
490
NINNNNNNNN IMEDPMADT