Q20351

PR
Gene name
tpst-2 (F42G9.8)
Protein name
Putative protein-tyrosine sulfotransferase
Names
Tyrosylprotein sulfotransferase, TPST
Species
Caenorhabditis elegans
KEGG Pathway
EC number
2.8.2.20: Sulfotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

156-231 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q20351

Entry ID Method Resolution Chain Position Source
AF-Q20351-F1 Predicted AlphaFoldDB

No variants for Q20351

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q20351

No associated diseases with Q20351

No regional properties for Q20351

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q20351

Functions

Description
EC Number 2.8.2.20 Sulfotransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.

2 GO annotations of molecular function

Name Definition
protein-tyrosine sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate.
sulfotransferase activity Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.

1 GO annotations of biological process

Name Definition
peptidyl-tyrosine sulfation The sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VYB7 Tpst Protein-tyrosine sulfotransferase Drosophila melanogaster (Fruit fly) PR
10 20 30 40 50 60
MRAILDAHPD VRCGGETMLL PSFLTWQAGW RNDWVNNSGI TQEVFDDAVS AFITEIVAKH
70 80 90 100 110 120
SELAPRLCNK DPYTALWLPT IRRLYPNAKF ILMIRDARAV VHSMIERKVP VAGYNTSDEI
130 140 150 160 170 180
SMFVQWNQEL RKMTFQCNNA PGQCIKVYYE RLIQKPAEEI LRITNFLDLP FSQQMLRHQD
190 200 210 220 230 240
LIGDEVDLND QEFSASQVKN SINTKALTSW FDCFSEETLR KLDDVAPFLG ILGYDTSISK
250
PDYSTFADDD FYQFKNFYS