AiPD: Autoinhibited Protein Database

Gene name	Frl
Protein name	Formin-like protein
Names	Formin related in leukocytes
Species	Oryza sativa subsp japonica (Rice)
KEGG Pathway	dme:Dmel_CG32138
EC number	2.7.12.2: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Target domain	687-1132 (FH2 domain)
Relief mechanism	Partner binding
Assay	Deletion assay, Mutagenesis experiment

125-373 (GBD and DID domains)

687-1132 (FH2 domain)

Partner binding (Cdc42 binding to GBD domain)

Deletion assay, Mutagenesis experiment

Target domain	687-1132 (FH2 domain)
Relief mechanism	Partner binding
Assay	Deletion assay, Mutagenesis experiment

1136-1169 (DAD domain)

687-1132 (FH2 domain)

Partner binding (Binding of activated GTPase)

Deletion assay, Mutagenesis experiment

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9VUC6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
No variants for Q9VUC6

Type	Name	Position	InterPro Accession
domain	SANT/Myb domain	159 - 250	IPR001005-1
domain	SANT/Myb domain	428 - 476	IPR001005-2
domain	SET domain	612 - 733	IPR001214
domain	CXC domain	503 - 605	IPR026489
domain	Tesmin/TSO1-like CXC domain	555 - 592	IPR033467
domain	Polycomb repressive complex 2 subunit EZH1/EZH2, tri-helical domain	158 - 249	IPR041343
domain	Pre-SET CXC domain	559 - 590	IPR041355
domain	EZH2, SET domain	609 - 728	IPR044439
domain	EZH1/2, MCSS domain	257 - 309	IPR048358

		Description
EC Number	2.7.12.2	Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Name	Definition
actin filament binding	Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
GTPase binding	Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP.
small GTPase binding	Binding to a small monomeric GTPase.

Name	Definition
axon extension	Long distance growth of a single axon process involved in cellular development.
cell migration	The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cortical actin cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
mushroom body development	The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells.
ommatidial rotation	The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification.
regulation of cell shape	Any process that modulates the surface configuration of a cell.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8IVF7	FMNL3	Formin-like protein 3	Homo sapiens (Human)	SS
O95466	FMNL1	Formin-like protein 1	Homo sapiens (Human)	SS
Q96PY5	FMNL2	Formin-like protein 2	Homo sapiens (Human)	SS
Q6ZPF4	Fmnl3	Formin-like protein 3	Mus musculus (Mouse)	SS
Q9JL26	Fmnl1	Formin-like protein 1	Mus musculus (Mouse)	SS
A2APV2	Fmnl2	Formin-like protein 2	Mus musculus (Mouse)	SS