Q96PY5

SS
Gene name
FMNL2 (FHOD2, KIAA1902)
Protein name
Formin-like protein 2
Names
Formin homology 2 domain-containing protein 2
Species
Homo sapiens (Human)
KEGG Pathway
hsa:114793
EC number
Protein Class

Descriptions

(Annotation from UniProt)
The DAD domain may regulate activation via by an autoinhibitory interaction with the N-terminus. This autoinhibition may be released upon competitive binding of an activated GTPase. The release of DAD may allow the FH2 domain to nucleate and elongate nonbranched actin filaments.

Autoinhibitory domains (AIDs)

1040-1079 (DAD domain) SS

Target domain

23-469 (GBD/FH3 domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q96PY5

Entry ID Method Resolution Chain Position Source
4YC7 X-ray 250 A B 1-379 PDB
AF-Q96PY5-F1 Predicted AlphaFoldDB

No variants for Q96PY5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q96PY5

No associated diseases with Q96PY5

18 regional properties for Q96PY5

Type Name Position InterPro Accession
domain FERM domain 37 - 380 IPR000299
domain Protein kinase domain 545 - 809 IPR000719-1
domain Protein kinase domain 849 - 1130 IPR000719-2
domain SH2 domain 397 - 487 IPR000980
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 546 - 805 IPR001245-1
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 849 - 1120 IPR001245-2
active_site Tyrosine-protein kinase, active site 972 - 984 IPR008266
binding_site Protein kinase, ATP binding site 855 - 883 IPR017441
domain FERM central domain 152 - 261 IPR019748
domain Band 4.1 domain 33 - 270 IPR019749
domain Tyrosine-protein kinase, catalytic domain 545 - 805 IPR020635-1
domain Tyrosine-protein kinase, catalytic domain 849 - 1123 IPR020635-2
domain Janus kinase 2, catalytic domain 844 - 1127 IPR035589
domain Tyrosine-protein kinase JAK2, SH2 domain 386 - 482 IPR035860
domain JAK2, FERM domain C-lobe 266 - 386 IPR037838
domain JAK, FERM F2 lobe domain 143 - 261 IPR041046
domain FERM F1 lobe ubiquitin-like domain 39 - 134 IPR041155
domain JAK1-3/TYK2, pleckstrin homology-like domain 302 - 381 IPR041381

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
actin filament binding Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
cadherin binding Binding to cadherin, a type I membrane protein involved in cell adhesion.
small GTPase binding Binding to a small monomeric GTPase.

5 GO annotations of biological process

Name Definition
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cortical actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
regulation of cell morphogenesis Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized.
regulation of cell shape Any process that modulates the surface configuration of a cell.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VUC6 Frl Formin-like protein Drosophila melanogaster (Fruit fly) EV
Q8IVF7 FMNL3 Formin-like protein 3 Homo sapiens (Human) SS
O95466 FMNL1 Formin-like protein 1 Homo sapiens (Human) SS
Q6ZPF4 Fmnl3 Formin-like protein 3 Mus musculus (Mouse) SS
Q9JL26 Fmnl1 Formin-like protein 1 Mus musculus (Mouse) SS
A2APV2 Fmnl2 Formin-like protein 2 Mus musculus (Mouse) SS
10 20 30 40 50 60
MGNAGSMDSQ QTDFRAHNVP LKLPMPEPGE LEERFAIVLN AMNLPPDKAR LLRQYDNEKK
70 80 90 100 110 120
WELICDQERF QVKNPPHTYI QKLKGYLDPA VTRKKFRRRV QESTQVLREL EISLRTNHIG
130 140 150 160 170 180
WVREFLNEEN KGLDVLVEYL SFAQYAVTFD FESVESTVES SVDKSKPWSR SIEDLHRGSN
190 200 210 220 230 240
LPSPVGNSVS RSGRHSALRY NTLPSRRTLK NSRLVSKKDD VHVCIMCLRA IMNYQYGFNM
250 260 270 280 290 300
VMSHPHAVNE IALSLNNKNP RTKALVLELL AAVCLVRGGH EIILSAFDNF KEVCGEKQRF
310 320 330 340 350 360
EKLMEHFRNE DNNIDFMVAS MQFINIVVHS VEDMNFRVHL QYEFTKLGLD EYLDKLKHTE
370 380 390 400 410 420
SDKLQVQIQA YLDNVFDVGA LLEDAETKNA ALERVEELEE NISHLSEKLQ DTENEAMSKI
430 440 450 460 470 480
VELEKQLMQR NKELDVVREI YKDANTQVHT LRKMVKEKEE AIQRQSTLEK KIHELEKQGT
490 500 510 520 530 540
IKIQKKGDGD IAILPVVASG TLSMGSEVVA GNSVGPTMGA ASSGPLPPPP PPLPPSSDTP
550 560 570 580 590 600
ETVQNGPVTP PMPPPPPPPP PPPPPPPPPP PPPLPGPAAE TVPAPPLAPP LPSAPPLPGT
610 620 630 640 650 660
SSPTVVFNSG LAAVKIKKPI KTKFRMPVFN WVALKPNQIN GTVFNEIDDE RILEDLNVDE
670 680 690 700 710 720
FEEIFKTKAQ GPAIDLSSSK QKIPQKGSNK VTLLEANRAK NLAITLRKAG KTADEICKAI
730 740 750 760 770 780
HVFDLKTLPV DFVECLMRFL PTENEVKVLR LYERERKPLE NLSDEDRFMM QFSKIERLMQ
790 800 810 820 830 840
KMTIMAFIGN FAESIQMLTP QLHAIIAASV SIKSSQKLKK ILEIILALGN YMNSSKRGAV
850 860 870 880 890 900
YGFKLQSLDL LLDTKSTDRK QTLLHYISNV VKEKYHQVSL FYNELHYVEK AAAVSLENVL
910 920 930 940 950 960
LDVKELQRGM DLTKREYTMH DHNTLLKEFI LNNEGKLKKL QDDAKIAQDA FDDVVKYFGE
970 980 990 1000 1010 1020
NPKTTPPSVF FPVFVRFVKA YKQAEEENEL RKKQEQALME KLLEQEALME QQDPKSPSHK
1030 1040 1050 1060 1070 1080
SKRQQQELIA ELRRRQVKDN RHVYEGKDGA IEDIITVLKT VPFTARTAKR GSRFFCEPVL
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