Q9VTK2

PR
Gene name
rt
Protein name
Protein O-mannosyltransferase 1
Names
Dolichyl-phosphate-mannose--protein mannosyltransferase 1, dPOMT1, Protein rotated abdomen
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG6097
EC number
2.4.1.109: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

71-188 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VTK2

Entry ID Method Resolution Chain Position Source
AF-Q9VTK2-F1 Predicted AlphaFoldDB

No variants for Q9VTK2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VTK2

No associated diseases with Q9VTK2

3 regional properties for Q9VTK2

Type Name Position InterPro Accession
domain Glycosyl transferase family 39/83 179 - 420 IPR003342
domain MIR motif 450 - 642 IPR016093
domain Protein O-mannosyl-transferase, C-terminal four TM domain 672 - 875 IPR032421

Functions

Description
EC Number 2.4.1.109 Hexosyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
dolichyl-phosphate-mannose-protein mannosyltransferase complex A complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity; usually includes members of the PMT1 and PMT2 protein subfamilies.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
dolichyl-phosphate-mannose-protein mannosyltransferase activity Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.

7 GO annotations of biological process

Name Definition
muscle attachment The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).
muscle organ development The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
protein O-linked mannosylation The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage.
regulation of synaptic activity Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell.
sarcomere organization The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
somatic muscle development The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle.
specification of segmental identity, abdomen The specification of the characteristic structures of the abdominal segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P46971 PMT4 Dolichyl-phosphate-mannose--protein mannosyltransferase 4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9UKY4 POMT2 Protein O-mannosyl-transferase 2 Homo sapiens (Human) PR
Q8BGQ4 Pomt2 Protein O-mannosyl-transferase 2 Mus musculus (Mouse) PR
10 20 30 40 50 60
MSATYTNTIT QRRKTAKVRQ QQQHQWTGSD LSGESNERLH FRSRSTNSMQ QHTAISNSPS
70 80 90 100 110 120
PLCCNGARAL TMLNCCVDVN CHLNAPLRGS VNRHTTPTPT PTATPTPVAT PKQASPSPTS
130 140 150 160 170 180
DRSRSLSRSP SPSRSRSLSC QKQIDKNSAG AASAEERKTA NASSQPFTVN LRIDLFSWTL
190 200 210 220 230 240
FLLAFGTRFY KLATPPHIVF DELHYGKYIS MYMRNIFFFD QHPPLGKQLI AGLVSLAGYD
250 260 270 280 290 300
GNYTFTRIGE PYSPEMPIFW FRFLPAMCGS LLAPAVYNLL LEAKLSRWSS ALGGLLVVLD
310 320 330 340 350 360
NSLLTQSRFV LMESMLLLAT TVGIACLLRF QRSRLGSLEW FFTGTAAAVC LGAAGTVKYV
370 380 390 400 410 420
GFLALGLAFY LLCRHLWQLL YDAGLTDRQL WMHAISRLLI FVGIPLAVYL GVFYIHFKTL
430 440 450 460 470 480
HRAGPHDSIM TSAFQASLDG GLASITKGQP LAVVHGSQIT LRHTHGRTCW LHSHAAVYPV
490 500 510 520 530 540
RYPDKRGSSH QQQVTCYSFK DVNNWWLVKR PTKENLVVGD EPDIIRHGEI IQLVHGITSR
550 560 570 580 590 600
ALNSHDVAAA MTPQCQEVSC YIDYEIKMAG ELLWRVEILN RDSEGDIWHA IKSEVRLVHV
610 620 630 640 650 660
STEASLKFSG RQLPEWGFNQ HEVVADREKA IHEDAIWNVE EHRYTQTEDH RERERQMLTA
670 680 690 700 710 720
EMIPTKRTRI SFWAKLLELQ SKMLFQTKSV PNHMYSSMPH EWPLMDKGIA YWLDSQSSAQ
730 740 750 760 770 780
IYLLGNILLW YTATMGILVY AGLLAFYAMR RQRLCFDISE QEWQRFVLAG DTFFMGYVMH
790 800 810 820 830 840
YIPYFCVDRT LFLHNYLPAF VFKLLLLCFV VEHLDYLLRR FCTGRGVHLV RLYRLMLILW
850 860 870 880
LVGVLSIFSK FIPFSYGARK MTLNEVRSLR WKDTWDFVLH KNHHLY