Q8BGQ4
Gene name |
Pomt2 |
Protein name |
Protein O-mannosyl-transferase 2 |
Names |
Dolichyl-phosphate-mannose--protein mannosyltransferase 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:217734 |
EC number |
2.4.1.109: Hexosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BGQ4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BGQ4-F1 | Predicted | AlphaFoldDB |
39 variants for Q8BGQ4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs266078404 | 95 | A>P | No | EVA | |
| rs3389245129 | 218 | C>Y | No | EVA | |
| rs3389225825 | 220 | F>I | No | EVA | |
| rs3389262507 | 226 | I>F | No | EVA | |
| rs3389260464 | 249 | L>R | No | EVA | |
| rs3389237544 | 253 | D>E | No | EVA | |
| rs3403662146 | 271 | F>Y | No | EVA | |
| rs3402829759 | 272 | F>L | No | EVA | |
| rs3403662137 | 281 | V>A | No | EVA | |
| rs3389249324 | 351 | A>D | No | EVA | |
| rs228681671 | 373 | M>I | No | EVA | |
| rs3389250415 | 378 | S>G | No | EVA | |
| rs3389211368 | 386 | S>G | No | EVA | |
| rs3389267096 | 401 | A>T | No | EVA | |
| rs3402829794 | 406 | H>N | No | EVA | |
| rs3389253714 | 448 | H>L | No | EVA | |
| rs3389220814 | 481 | I>V | No | EVA | |
| rs3389211318 | 516 | G>V | No | EVA | |
| rs3389247245 | 517 | T>K | No | EVA | |
| rs3389211379 | 518 | G>V | No | EVA | |
| rs3389249255 | 526 | I>F | No | EVA | |
| rs3389250451 | 533 | F>Y | No | EVA | |
| rs3389255088 | 548 | H>Y | No | EVA | |
| rs3389262505 | 570 | L>S | No | EVA | |
| rs3389245147 | 592 | I>T | No | EVA | |
| rs3389255090 | 630 | D>G | No | EVA | |
| rs3389249263 | 636 | K>Q | No | EVA | |
| rs3389267143 | 638 | W>C | No | EVA | |
| rs3389211425 | 639 | H>Y | No | EVA | |
| rs3389267064 | 649 | F>I | No | EVA | |
| rs3389184476 | 654 | D>E | No | EVA | |
| rs3389267087 | 657 | F>L | No | EVA | |
| rs3389184410 | 674 | S>R | No | EVA | |
| rs3389255025 | 687 | V>M | No | EVA | |
| rs3389184421 | 721 | Y>N | No | EVA | |
| rs226870299 | 764 | P>S | No | EVA | |
| rs3389262442 | 774 | V>M | No | EVA | |
| rs3389260417 | 782 | T>I | No | EVA | |
| rs3389267104 | 802 | A>V | No | EVA |
No associated diseases with Q8BGQ4
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.1.109 | Hexosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| dolichyl-phosphate-mannose-protein mannosyltransferase activity | Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein. |
| mannosyltransferase activity | Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of protein O-linked glycosylation | Any process that activates or increases the frequency, rate or extent of protein O-linked glycosylation. |
| protein O-linked mannosylation | The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLYASGRLLA | ARAATTLSAP | PRARGPALRG | KRRELQIPWH | LETPSYDPLT | GQRTRPGVPP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ARRVILRKGR | MPPAIGGGLA | GSELRPRRGR | CVPQAARAVS | RDVVPQAAAR | KLKRPAWSSR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RFQAAGWWAT | LAVVTLLSFA | TRFHRLDQPA | HICWDETHFG | KMGSYYINRT | FFFDVHPPLG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KMLIGLAGYL | SGYDGTFLFQ | KPGDRYEHHS | YMGMRGFCAF | LGSWLIPFAY | LTVLDLSKSF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PAALLTAALL | TFDTGCLTLS | QYILLDPILM | FFIMAAMLSM | VKYNSCANRP | FSAPWWFWLS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LTGISLAGAL | GVKFVGLFII | VQVGLNTISD | LWHLFGDLSL | SLVTVGKHLT | ARILCLIVLP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LVLYVTIFAV | HVMVLNKSGP | GDGFFSSAFQ | ARLSGNSLHN | ASIPEHLAYG | SVITVKNLRM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AIGYLHSHRH | LYPEGIGARQ | QQVTTYLHKD | YNNLWIIKKY | NANTDPLDPS | FPVEFVRHGD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IIRLEHKETT | RNLHSHYHEA | PLTRKHYQVT | GYGINGTGDS | NDFWRIEVVN | RKFGNRIKVL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RSRIRLIHLV | TGCVLGSSGK | ILPKWGWEQL | EVTCTPYLKE | TTNSIWNIEE | HINPKLPNIS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LDVLQPSFPE | ILLESHMVMI | RGNNGLKPKD | NEFTSKPWHW | PINYQGLRFS | GANDTDFRVY |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LLGNPVVWWL | NLVSIVLYLL | SGSTIAVAMQ | RGIQLPAELQ | GLTKVLLRGG | GQLLLGWMLH |
| 730 | 740 | 750 | 760 | 770 | 780 |
| YFPFFLMGRI | LYFHHYFPAM | LFSSMLTGIL | WDTLLRLCAW | GLAPSPLGRR | IHAVGILSLL |
| 790 | 800 | 810 | |||
| LTTAYSFYLF | HPLAYGMVGP | LAQEPESPMA | GLRWLESWDF |