Q9VNH6

PR
Gene name
Sec8
Protein name
Exocyst complex component 4
Names
Exocyst complex component Sec8
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG2095
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

428-497 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VNH6

Entry ID Method Resolution Chain Position Source
AF-Q9VNH6-F1 Predicted AlphaFoldDB

No variants for Q9VNH6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VNH6

No associated diseases with Q9VNH6

1 regional properties for Q9VNH6

Type Name Position InterPro Accession
domain Gamma-carboxyglutamic acid-rich (GLA) domain 33 - 98 IPR000294

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

10 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
basal plasma membrane The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals.
growth cone membrane The portion of the plasma membrane surrounding a growth cone.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
presynapse The part of a synapse that is part of the presynaptic cell.
rhabdomere The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

19 GO annotations of biological process

Name Definition
actomyosin contractile ring contraction The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle.
border follicle cell migration The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
chemical synaptic transmission The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
Golgi to plasma membrane transport The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.
meiosis I cytokinesis A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells.
meiosis II cytokinesis A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells.
meiotic spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle.
neurotransmitter secretion The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
plasma membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.
positive regulation of synaptic assembly at neuromuscular junction Any process that activates or increases the frequency, rate or extent of synaptic assembly at neuromuscular junction.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of synapse structure or activity Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
spermatid development The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
synaptic vesicle docking The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process.
synaptic vesicle targeting The process in which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces.
vesicle tethering involved in exocytosis The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
viral entry into host cell The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96A65 EXOC4 Exocyst complex component 4 Homo sapiens (Human) PR
10 20 30 40 50 60
MDAPPPTKPP RGVKYGKDES AGCGFLVNVI KSLGFSETTE ERQKEKQKIE AEFKRSDLRL
70 80 90 100 110 120
NELVSRHDQQ LTQVLPLFSQ VSSEVTASRE RIHAVKENLG VCKRLLQCRR DELRKMWMDA
130 140 150 160 170 180
VQHKYVLEML EQIQELRKVP QRVVGYTAKR QYLHASKALT DALTTLNGPL QAVEGLSDLR
190 200 210 220 230 240
TDLQTRRQQL YQRLHEELVT QVYTNSANEA LSSFQRTNSS RLNSSFTRGI GARRSTDRIE
250 260 270 280 290 300
ANARVRKALA EMAQSFDLDK AEVIEDADLI YPELSMSYFV AIIVESFGML HKVPDSLETL
310 320 330 340 350 360
RVQIQTELLN VVRHTTHQLS VSGATADTNP LLSLLEVIFK QFKAIAKTHS LLLKNYLSVG
370 380 390 400 410 420
QKYSVVGPQP YDLTDFWAQA QSVLQLLLTD YLDIQNAAAD ESAQTGFSEP TSNINSYFLR
430 440 450 460 470 480
RKVPSTKRSM FKFDKSSHVG TSNNSDAFKE HRRNASDASV DDNLAGQLGG SGKGSTSGLF
490 500 510 520 530 540
PHEKKQREKI LICTPDQSII TKVYLPLMGY IKEIENFMKC KPGQPCSLHD FLDNYIKDTF
550 560 570 580 590 600
LTKGHNRNLQ LTIESLSKNQ DAWRTIISPE EIKALNLSRP LLQSTVMVER RLMETKNLIQ
610 620 630 640 650 660
DLPCYSEDLL KMVCALLKAY REICQAAYRG IVQPDSEDKR IYSVAWLKDE DISRFLKTLP
670 680 690 700 710 720
NWTDLKTYSQ KSRHNRKLHR GSFEPSEEES PLQVQQRNIR EAEMLTSNLG EGGITQQEIL
730 740 750 760 770 780
VEISVLKELA ILQESMEWFS CRVSEFANDL RRPLVNGLNA VPAECGADIA VKDGTIKVMT
790 800 810 820 830 840
NLALEFDELA NTCLLVLHLE VRVQCFHYLR SKSSVRTNSY VGSKDDILEP DRQVQVLTKR
850 860 870 880 890 900
LSEMDEAFSA TLHPRKTRYI FEGLAHLASR ILIQASNYLE HIDQITVQRM CRNAIALQQT
910 920 930 940 950 960
LSNITASREV ALDQARHFYE LLCMEPDEIL NALLERGTQF SEMQLLNALQ LSCKSFGITD
970 980
ANLLASYQQK LSDILGAKPS KGVVV