Q9VLD6

PR
Gene name
borr (CG4454)
Protein name
Borealin
Names
Aurora borealis protein, Borealin-related
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG4454
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

61-252 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VLD6

Entry ID Method Resolution Chain Position Source
AF-Q9VLD6-F1 Predicted AlphaFoldDB

No variants for Q9VLD6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VLD6

No associated diseases with Q9VLD6

10 regional properties for Q9VLD6

Type Name Position InterPro Accession
domain Cadherin-like 28 - 133 IPR002126-1
domain Cadherin-like 139 - 242 IPR002126-2
domain Cadherin-like 242 - 350 IPR002126-3
domain Cadherin-like 351 - 565 IPR002126-4
domain Cadherin-like 588 - 678 IPR002126-5
domain Cadherin, N-terminal 30 - 111 IPR013164
conserved_site Cadherin conserved site 230 - 240 IPR020894-1
conserved_site Cadherin conserved site 443 - 453 IPR020894-2
conserved_site Cadherin conserved site 553 - 563 IPR020894-3
domain Cadherin, C-terminal catenin-binding domain 798 - 931 IPR031904

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome, centromere
  • Cytoplasm, cytoskeleton, spindle
  • Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis
  • Colocalizes with and is required for the correct localization of the CPC components Aurora B kinase and Incenp in mitotic cells
  • Is absent from spermatocytes undergoing meiosis
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
chromosome passenger complex A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin.
chromosome, centromeric region The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
kinetochore A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
meiotic spindle midzone The area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spindle midzone The area in the center of the spindle where the spindle microtubules from opposite poles overlap.

1 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

3 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
mitotic sister chromatid segregation The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
protein localization to spindle microtubule A process in which a protein is transported to, or maintained in, a location within a spindle microtubule.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q53HL2 CDCA8 Borealin Homo sapiens (Human) PR
10 20 30 40 50 60
MPRTKIPKNS KRNREVANRE EKVRLYELKM DSRLISIDSL ETKFLSAVDH QVKTLLGQVQ
70 80 90 100 110 120
KELANLKMPE VLRLFEELDR FSDFKASDQT QLLASMSMSG SAIEGHAPSA TGSRNDEEDS
130 140 150 160 170 180
SIGASGGSIL AAHTGSLLRS TKAMRTPGPL HSARARRARR SRSACGDLNI LHSAKPPSIS
190 200 210 220 230 240
SSSSSSRNSR SKLRTPMASR AKAFSADRTP LKQKQMRSGS PTTPPMAFLR YPKPGEVALS
250 260 270 280 290 300
KYGSPMVAQV MPDKFANVNI PIRNGVLSLR PKKLDADEVE SNLLENLDED TLNQIKTLHE
310
NLQMIVNKAS QAVFK