AiPD: Autoinhibited Protein Database

Q53HL2

Gene name	CDCA8 (PESCRG3)
Protein name	Borealin
Names	Cell division cycle-associated protein 8, Dasra-B, hDasra-B, Pluripotent embryonic stem cell-related gene 3 protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:55143
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

116-199 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

116-199 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

9 structures for Q53HL2

Entry ID	Method	Resolution	Chain	Position	Source
2KDD	NMR	-	A/B	207-280	PDB
2QFA	X-ray	140 A	B	15-76	PDB
2RAW	X-ray	240 A	B	20-78	PDB
2RAX	X-ray	330 A	B/F/Y	20-78	PDB
6YIE	X-ray	349 A	B/E	10-109	PDB
6YIF	X-ray	181 A	B	10-76	PDB
6YIH	X-ray	255 A	B	10-76	PDB
7U5V	X-ray	259 A	C	137-145	PDB
AF-Q53HL2-F1	Predicted				AlphaFoldDB

200 variants for Q53HL2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs781286827 CA772977	2	A>P		No	ClinGen ExAC gnomAD
CA339434721 rs781286827	2	A>T		No	ClinGen ExAC gnomAD
CA339434739 rs923961297	3	P>A		No	ClinGen gnomAD
CA20800356 rs923961297	3	P>S		No	ClinGen gnomAD
rs936678581 CA20800357	4	R>K		No	ClinGen Ensembl
CA20800360 rs748201253	5	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1339442096 CA339434814	6	G>V		No	ClinGen gnomAD
CA339434850 rs1570272424	8	S>I		No	ClinGen Ensembl
CA339434856 rs1294841074	8	S>R		No	ClinGen gnomAD
CA772980 rs778078602	9	R>W		No	ClinGen ExAC TOPMed gnomAD
CA772981 rs749680803	11	A>S		No	ClinGen ExAC gnomAD
CA772982 rs771261679	12	K>E		No	ClinGen ExAC gnomAD
CA20800396 rs17851453 VAR_027063	12	K>N		No	ClinGen UniProt Ensembl dbSNP
CA772983 rs368533643	12	K>T		No	ClinGen ESP ExAC gnomAD
CA339434933 rs1570272481	14	N>T		No	ClinGen Ensembl
rs776659425 CA20800408	17	R>P		No	ClinGen TOPMed gnomAD
CA339434977 rs776659425	17	R>Q		No	ClinGen TOPMed gnomAD
CA20800412 rs893062282	18	R>W		No	ClinGen Ensembl
rs543224748 CA339435003	19	R>L		No	ClinGen 1000Genomes TOPMed
rs543224748 CA20800416	19	R>Q		No	ClinGen 1000Genomes TOPMed
rs771828918 CA772985	21	L>F		No	ClinGen ExAC TOPMed gnomAD
CA339435051 rs1186113176	23	S>F		No	ClinGen TOPMed gnomAD
CA339435047 rs1423766049	23	S>P		No	ClinGen gnomAD
TCGA novel	27	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA339435098 rs1158711892	27	D>Y		No	ClinGen gnomAD
CA772989 rs776371441 CA20800423	28	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs532039712 CA772990	32	V>L		No	ClinGen 1000Genomes ExAC gnomAD
CA773017 rs757730266	35	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA773018 rs779438508	41	S>P		No	ClinGen ExAC TOPMed gnomAD
CA773019 rs750820280	42	D>V		No	ClinGen ExAC gnomAD
CA773020 rs758775604	43	R>K		No	ClinGen ExAC TOPMed gnomAD
rs1173728637 CA339435475	44	Q>K		No	ClinGen gnomAD
CA339435538 rs1488781095	48	K>R		No	ClinGen gnomAD
CA339435555 rs1169929067	50	V>M		No	ClinGen TOPMed gnomAD
rs768323749 CA773023	51	D>Y		No	ClinGen ExAC gnomAD
rs780615091 CA773024	53	L>V		No	ClinGen ExAC TOPMed
rs1294131496 CA339435599	54	Y>C		No	ClinGen gnomAD
rs1367179797 CA339435613	55	N>S		No	ClinGen gnomAD
CA773027 rs577147430	56	I>V		No	ClinGen ExAC TOPMed gnomAD
rs770780603 CA773029	62	P>A		No	ClinGen ExAC gnomAD
CA339435706 rs1557513596	64	A>V		No	ClinGen Ensembl
rs1487965570 CA339435737	67	E>G		No	ClinGen gnomAD
rs760860469 CA773031	68	M>T		No	ClinGen ExAC gnomAD
rs142003803 CA773030	68	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA773032 rs764332205	70	W>*		No	ClinGen ExAC TOPMed gnomAD
rs369811875 CA339435845	75	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA773033 rs369811875	75	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1315331301 CA339436198	76	L>F		No	ClinGen TOPMed
rs768767817 CA773049	77	G>E		No	ClinGen ExAC gnomAD
CA339436202 rs1557515574	77	G>R		No	ClinGen Ensembl
rs1449171981 CA339436217	79	N>S		No	ClinGen gnomAD
CA339436237 rs1302841587	82	A>T		No	ClinGen gnomAD
CA339436264 rs1224241026	86	A>T		No	ClinGen TOPMed
rs765476841 COSM909030 CA773052	86	A>V	endometrium Variant assessed as Somatic; 4.62e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs764780292 CA20801927	88	T>I		No	ClinGen Ensembl
CA339436293 rs1232799486	89	A>P		No	ClinGen Ensembl
CA20803564 rs559744929	89	A>V		No	ClinGen TOPMed gnomAD
CA773070 rs770114051	90	D>A		No	ClinGen ExAC gnomAD
CA773069 rs748439582	90	D>N		No	ClinGen ExAC gnomAD
CA773071 rs773447308	91	L>M		No	ClinGen ExAC gnomAD
CA773074 rs774862393	95	E>D		No	ClinGen ExAC gnomAD
rs370815676 CA773073	95	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA339436425 rs1423444159	101	A>P		No	ClinGen gnomAD
CA339436447 rs1411981764	102	E>A		No	ClinGen gnomAD
rs1172068276 CA339436453	103	A>T		No	ClinGen gnomAD
rs543110631 CA20803601	104	I>V		No	ClinGen 1000Genomes gnomAD
CA773075 rs76059772	105	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1328602902 CA339436531	107	P>S		No	ClinGen gnomAD
CA339436597 rs1436687521	112	K>E		No	ClinGen gnomAD
rs533338748 CA773077	112	K>R		No	ClinGen 1000Genomes ExAC gnomAD
CA773096 rs35565540	114	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs370260234 CA773098	115	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs201801454 CA773097	115	K>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs760966595 CA773100	117	I>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	118	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1484824740 CA339437311	118	Q>H		No	ClinGen TOPMed
CA773101 rs763752360	118	Q>R		No	ClinGen ExAC gnomAD
CA20804724 rs145236103	120	D>E		No	ClinGen ESP TOPMed gnomAD
TCGA novel	120	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA773102 rs753549817	124	V>M		No	ClinGen ExAC TOPMed gnomAD
CA339437600 rs1247596069	128	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs761448099 CA773105	131	E>D		No	ClinGen ExAC gnomAD
rs1356550984 CA339437725	133	E>Q		No	ClinGen TOPMed
CA773106 rs201050786	134	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA773107 rs149123241	134	R>H		No	ClinGen ESP ExAC TOPMed
CA773108 rs149123241	134	R>P		No	ClinGen ESP ExAC TOPMed
CA773110 rs565423678	135	K>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA20804791 rs866644775	139	T>N		No	ClinGen Ensembl
CA339437908 rs751403716	140	A>S		No	ClinGen ExAC gnomAD
rs751403716 CA773111	140	A>T		No	ClinGen ExAC gnomAD
CA773112 rs754759907	140	A>V		No	ClinGen ExAC TOPMed gnomAD
CA773113 rs781119414	141	R>T		No	ClinGen ExAC gnomAD
rs1570280655 CA339438707	142	V>I		No	ClinGen Ensembl
CA20805652 rs965003733	143	K>N		No	ClinGen Ensembl
rs151151394 CA773127	143	K>R		No	ClinGen ESP ExAC gnomAD
CA339438746 rs1163888824	144	R>K		No	ClinGen TOPMed
CA20805656 rs974670997	145	C>*		No	ClinGen Ensembl
rs762302397 CA773128	146	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs766351022 CA773129	147	P>S		No	ClinGen ExAC gnomAD
rs546751848 CA773130	148	S>F		No	ClinGen 1000Genomes ExAC gnomAD
CA339438844 rs1275596451	149	K>N		No	ClinGen gnomAD
CA339438832 rs1158918871	149	K>T		No	ClinGen gnomAD
rs1379302126 CA339438854	150	K>E		No	ClinGen gnomAD
CA20805672 rs933665476	150	K>N		No	ClinGen TOPMed gnomAD
rs754936582 CA773131	155	I>V		No	ClinGen ExAC gnomAD
CA339439007 rs1437310353	157	G>E		No	ClinGen TOPMed
CA339438995 rs1402833814	157	G>R		No	ClinGen gnomAD
rs767470650 CA773133	161	G>A		No	ClinGen ExAC
CA339439075 rs1334576531	162	K>R		No	ClinGen TOPMed gnomAD
CA773151 rs767523357	163	R>S		No	ClinGen ExAC gnomAD
rs200238492 CA773153	164	S>*		No	ClinGen ExAC gnomAD
CA773152 rs755811056	164	S>T		No	ClinGen ExAC TOPMed gnomAD
rs750680946 CA773154	165	S>G		No	ClinGen ExAC gnomAD
rs374879708 CA773155	166	R>C		No	ClinGen ExAC gnomAD
rs780154830 CA773156	166	R>H		No	ClinGen ExAC gnomAD
rs961411785 CA20806763	169	T>I		No	ClinGen Ensembl
CA20806767 rs1005107401	170	V>L		No	ClinGen TOPMed
rs755507277 CA773158	171	T>I		No	ClinGen ExAC TOPMed gnomAD
rs747037706 CA773157	171	T>P		No	ClinGen ExAC gnomAD
rs755507277 CA339439195	171	T>S		No	ClinGen ExAC TOPMed gnomAD
CA773159 rs199832856	172	P>L		No	ClinGen 1000Genomes ExAC gnomAD
CA773160 rs748558450	173	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA773162 rs773619945	174	V>M		No	ClinGen ExAC TOPMed gnomAD
CA773163 rs748943554	175	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1425707342 CA339439231	176	R>*		No	ClinGen TOPMed gnomAD
COSM187074 rs761391083 CA773164	176	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA773166 rs140856315	177	L>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA339439261 rs1352877317	179	V>M		No	ClinGen gnomAD
CA339439285 rs1412468497	181	M>T		No	ClinGen TOPMed
rs767578971 CA773167	181	M>V		No	ClinGen ExAC gnomAD
TCGA novel	183	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1570281719 CA339439331	184	P>L		No	ClinGen Ensembl
rs1294398050 CA339439336	185	T>A		No	ClinGen gnomAD
rs775352060 CA773168	186	P>L		No	ClinGen ExAC gnomAD
TCGA novel	187	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760660133 CA773169	187	G>S		No	ClinGen ExAC gnomAD
rs1238649783 CA339439398	190	P>S		No	ClinGen TOPMed
CA339439485 rs1218611587	194	S>A		No	ClinGen gnomAD
rs1479531694 CA339439504	195	R>T		No	ClinGen TOPMed
CA339439499 rs1197838409	195	R>W		No	ClinGen TOPMed
CA773194 rs751835840	197	F>L		No	ClinGen ExAC gnomAD
rs766601028 CA773193	197	F>L		No	ClinGen ExAC gnomAD
CA773195 rs759750134	199	T>I		No	ClinGen ExAC
CA339440174 rs1215618838	199	T>P		No	ClinGen gnomAD
CA339440191 rs1240287033	200	P>R		No	ClinGen gnomAD
CA339440221 rs1557519027	203	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA20807987 rs1028578994 COSM909032	203	R>H	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA339440228 rs1484159679	204	T>A		No	ClinGen gnomAD
CA339440247 rs1265301234	205	P>L		No	ClinGen TOPMed
CA339440257 rs1557519042	206	A>V		No	ClinGen Ensembl
rs767623323 CA773196	207	A>G		No	ClinGen ExAC TOPMed gnomAD
rs1008436119 CA20807993	209	E>K		No	ClinGen TOPMed gnomAD
CA339440285 rs1008436119	209	E>Q		No	ClinGen TOPMed gnomAD
CA773197 rs752774201	210	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA20808007 rs958970546	210	R>W		No	ClinGen gnomAD
CA339440316 rs1326715133	211	I>T		No	ClinGen TOPMed
CA773200 rs754168597	213	N>H		No	ClinGen ExAC gnomAD
rs1157305874 CA339440341	213	N>S		No	ClinGen gnomAD
rs1361429999 CA339440361	214	I>T		No	ClinGen gnomAD
CA773201 rs757758118	215	S>L		No	ClinGen ExAC gnomAD
CA20808031 rs577497 CA20808027	217	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA20808039 rs371795365	219	S>N		No	ClinGen ESP
rs748136648 CA20808048	220	P>L		No	ClinGen gnomAD
CA773203 rs745560335	220	P>S		No	ClinGen ExAC gnomAD
TCGA novel	221	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	222	A>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs376693211 CA773204	223	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA773205 rs779449327	225	K>E		No	ClinGen ExAC gnomAD
CA773206 rs746483715	225	K>R		No	ClinGen ExAC gnomAD
rs776570068 CA773208	226	E>K		No	ClinGen ExAC gnomAD
rs143404890 CA773209	227	I>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs769642478 CA773210	229	L>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	230	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA339440658 rs140308075	235	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs140308075 CA773212	235	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1415381117 CA339440686	236	G>E		No	ClinGen gnomAD
rs1040939534 CA20808103	236	G>R		No	ClinGen TOPMed gnomAD
CA773235 rs776833639	238	S>G		No	ClinGen ExAC gnomAD
rs183128146 CA20808785	239	L>V		No	ClinGen 1000Genomes ExAC gnomAD
rs765795028 CA773237	240	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
COSM274462 rs187658080 CA773238	240	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA20808795 rs868020307	243	A>V		No	ClinGen Ensembl
CA339441456 rs1194222539	249	H>Q		No	ClinGen TOPMed gnomAD
CA339441470 rs1205017701	250	S>N		No	ClinGen TOPMed
rs1007163560 CA20808797	251	I>T		No	ClinGen TOPMed gnomAD
CA20808800 rs868425508	258	A>S		No	ClinGen Ensembl
CA773240 rs377582484	261	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	262	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1420323025 CA339441687	262	I>V		No	ClinGen TOPMed gnomAD
rs560264444 CA20808804	264	K>Q		No	ClinGen TOPMed gnomAD
rs1452342142 CA339441752	265	L>I		No	ClinGen gnomAD
rs1452342142 CA339441753	265	L>V		No	ClinGen gnomAD
rs201991293 CA773269	267	N>K		No	ClinGen ExAC gnomAD
COSM909034 rs745614243 CA773270	268	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA773271 rs530473280	268	R>H		No	ClinGen 1000Genomes ExAC gnomAD
rs748365559 CA773273	270	A>T		No	ClinGen ExAC gnomAD
CA20809584 rs377421064	277	R>Q		No	ClinGen ESP TOPMed gnomAD
CA773274 rs770062752	277	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1279936358 CA339442954	280	K>I		No	ClinGen gnomAD
rs773393864 CA773275	281	K>W		No	ClinGen ExAC

No associated diseases with Q53HL2

No regional properties for Q53HL2

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q53HL2

Functions

		Description
EC Number
Subcellular Localization	Nucleus, nucleolus Cytoplasm Cytoplasm, cytoskeleton, spindle Chromosome, centromere	Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis Colocalizes with SENP3 in the nucleolus in interphase cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

11 GO annotations of cellular component

Name	Definition
chromocenter	A region in which centric, heterochromatic portions from more than one chromosomes form a compact structure.
chromosome passenger complex	A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin.
chromosome, centromeric region	The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
intercellular bridge	A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised.
microtubule cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
midbody	A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
spindle midzone	The area in the center of the spindle where the spindle microtubules from opposite poles overlap.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

13 GO annotations of biological process

Name	Definition
chromosome organization	A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
mitotic cell cycle	Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
mitotic cytokinesis	A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
mitotic metaphase plate congression	The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis.
mitotic sister chromatid segregation	The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
mitotic spindle midzone assembly	The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone.
mitotic spindle organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
positive regulation of attachment of mitotic spindle microtubules to kinetochore	Any process that activates or increases the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation.
positive regulation of mitotic cell cycle spindle assembly checkpoint	Any process that increases the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
positive regulation of mitotic cytokinesis	Any process that activates or increases the frequency, rate or extent of mitotic cytokinesis.
positive regulation of mitotic sister chromatid separation	Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid separation.
positive regulation of protein phosphorylation	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
protein phosphorylation	The process of introducing a phosphate group on to a protein.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9VLD6	borr	Borealin	Drosophila melanogaster (Fruit fly)	PR

10	20	30	40	50	60
MAPRKGSSRV	AKTNSLRRRK	LASFLKDFDR	EVEIRIKQIE	SDRQNLLKEV	DNLYNIEILR
70	80	90	100	110	120
LPKALREMNW	LDYFALGGNK	QALEEAATAD	LDITEINKLT	AEAIQTPLKS	AKTRKVIQVD
130	140	150	160	170	180
EMIVEEEEEE	ENERKNLQTA	RVKRCPPSKK	RTQSIQGKGK	GKRSSRANTV	TPAVGRLEVS
190	200	210	220	230	240
MVKPTPGLTP	RFDSRVFKTP	GLRTPAAGER	IYNISGNGSP	LADSKEIFLT	VPVGGGESLR
250	260	270
LLASDLQRHS	IAQLDPEALG	NIKKLSNRLA	QICSSIRTHK