Q9VGZ1

PR
Gene name
CG6345
Protein name
CDK5RAP1-like protein
Names
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG6345
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-114 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VGZ1

Entry ID Method Resolution Chain Position Source
AF-Q9VGZ1-F1 Predicted AlphaFoldDB

No variants for Q9VGZ1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VGZ1

No associated diseases with Q9VGZ1

5 regional properties for Q9VGZ1

Type Name Position InterPro Accession
domain TRAM domain 494 - 569 IPR002792
domain Elp3/MiaA/NifB-like, radical SAM core domain 241 - 483 IPR006638
domain Radical SAM 89 - 572 IPR007197
domain Methylthiotransferase, N-terminal 92 - 212 IPR013848
conserved_site Methylthiotransferase, conserved site 245 - 265 IPR020612

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
metal ion binding Binding to a metal ion.
N6-isopentenyladenosine methylthiotransferase activity Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-isopentenyladenosine (i6A) in tRNA, to form 2-methylthio-N6-isopentenyladenosine (ms2i6A).

2 GO annotations of biological process

Name Definition
negative regulation of cyclin-dependent protein serine/threonine kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
regulation of cyclin-dependent protein serine/threonine kinase activity Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2R1U4 Os11g0592800 CDK5RAP1-like protein Oryza sativa subsp japonica (Rice) PR
10 20 30 40 50 60
MKISYRAFVR QVRHASTTAS KGATTSVTSS AAGQLKSEPA ARATFLERIQ RGPGFQDFFA
70 80 90 100 110 120
VKPASRLKTD EEEHVDTSVP YLNSIDFNGN GRKVHFEVYG CQMNTNDTEV VFSILKENGY
130 140 150 160 170 180
LRCQEPEEAD VIMLVTCAVR DGAEQRIRNR LKHLRAMKNK RSTRRHPLQL TLLGCMAERL
190 200 210 220 230 240
KEKLLEQEQC VDVIAGPDSY KDLPRLLAIS RHYGNSAINV LLSLDETYAD VMPVRLNSES
250 260 270 280 290 300
PTAFVSIMRG CDNMCTYCIV PFTRGRERSR PLASIVAEVK ALAEQGVKEV TLLGQNVNSY
310 320 330 340 350 360
RDRTAQEEQD SLKATPVPGF STVYKPKTGG TPFAALLRSV AQAVPDMRIR FTSPHPKDFS
370 380 390 400 410 420
DEVLEVIRDH PNVCKQLHLP AQSGNTQVLE RMRRGYSREA YLELVQHIRQ FLPNVGLSSD
430 440 450 460 470 480
FICGFCGETE EEFQDTVSLI QQVQYNVAYL FAYSMREKTT AHRRYKDDVP INVKNERLQR
490 500 510 520 530 540
MVQVFREGAT QLHRKMEGQE QLILIEGKSK RSDAHWFGRN DANIKVIVPS IYVPISGDST
550 560 570 580
ARKSFGVGDF LAVRIEESNS QVLKGTPLEL SNITDFHSRQ LIQ