Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q2R1U4

Entry ID Method Resolution Chain Position Source
AF-Q2R1U4-F1 Predicted AlphaFoldDB

No variants for Q2R1U4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2R1U4

No associated diseases with Q2R1U4

5 regional properties for Q2R1U4

Type Name Position InterPro Accession
domain TRAM domain 504 - 580 IPR002792
domain Elp3/MiaA/NifB-like, radical SAM core domain 250 - 490 IPR006638
domain Radical SAM 91 - 584 IPR007197
domain Methylthiotransferase, N-terminal 93 - 222 IPR013848
conserved_site Methylthiotransferase, conserved site 254 - 274 IPR020612

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
metal ion binding Binding to a metal ion.
N6-isopentenyladenosine methylthiotransferase activity Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-isopentenyladenosine (i6A) in tRNA, to form 2-methylthio-N6-isopentenyladenosine (ms2i6A).

1 GO annotations of biological process

Name Definition
negative regulation of cyclin-dependent protein serine/threonine kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VGZ1 CG6345 CDK5RAP1-like protein Drosophila melanogaster (Fruit fly) PR
10 20 30 40 50 60
MAAPLTAAAA LRLGRGLSHR RAFLLRRRYS PAPLAPSPCA APRCLSSAAH PPPPPPRRLA
70 80 90 100 110 120
RSGPSRPLAA SAATAVSEAQ TDLESGPVTA SKGRIYHETY GCQMNVNDME IVLSIMKNEG
130 140 150 160 170 180
YDEIVPDPES AEIIFINTCA IRDNAEQKVW QRLNYFWFLK RQWKANVAAG RSRSLRPPKI
190 200 210 220 230 240
AVLGCMAERL KEKILDSDKM VDVVCGPDAY RDLPRLLQEV DYGQKGINTL LSLEETYADI
250 260 270 280 290 300
TPVRISDNSV TAFVSIMRGC NNMCSFCIVP FTRGRERSRP VSSIVREVGE LWKAGVKEVM
310 320 330 340 350 360
LLGQNVNSYN DTSEVEELEP GKNWELSEGF SSMCKVKNMG LRFADLLDQL SLEYPEMRFR
370 380 390 400 410 420
FTSPHPKDYP DELLYLMRDR HNVCKLIHMP AQSGSSAVLE RMRRGYTREA YLELVQKIRS
430 440 450 460 470 480
IIPDVGLSSD FISGFCGETE EEHAETLTLV RAVGYDMAYM FAYSMREKTH AHRNYVDDVP
490 500 510 520 530 540
DDVKQRRLAE LISTFRETTA KIYDSQVGTV QLVLVEGPNK RAPETEMIGK TDRGHRVSFA
550 560 570 580 590
SVPVPHTFEG DELRKPVVGD FIEVKITKSS TASLSGDVIA RTSLSKFYKN HSSEAHAVAA